Abstract
Sensitization of rats with homologous antigen of large intestine together with Freund's adjuvant causes marked immunological changes in the large intestine of rats with manifestations of enteritis in the small intestine. Oral administration of the flavonoid quercitrin in a dose of 25 or 100 mg/kg daily for 10 days leads to a decrease of the focal lymphohistiomonocytic infiltration and eosinophilic exudation in the mucous membrane and of the sclerotic changes in the stroma of the large intestine. Meanwhile the structural disturbances in the small intestine are repaired. The effect of quercitrin on morphological changes in the epithelium of the mucosa of the large and small intestine was very slight. It is postulated that the therapeutic action of quercitrin may be due to restoration of the local circulation when disturbed by sensitization of the animals.
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Literature Cited
V. A. Ado, Pat. Fiziol., No. 5, 82 (1974).
A. D. Ado, in: General Allergology [in Russian], Moscow (1970), pp. 435–461.
E. V. Andrushchenko, M. E. Shraibman, et al., in: Clinical Problems in Allergy [in Russian], Kiev (1963), pp. 109–118.
M. M. Dzhalilov, in: Proceedings of the Sixteenth Scientific Conference of Physiologists of the South RSFSR with the Participation of Biochemists and Pharmacologists [in Russian], Ordzhonikidze (1967). pp. 121–122.
V. K. Karnaukhov, Sov. Med., No. 5, 93, (1973).
K. Kirai and B. Padani, in: Some Aspects of Pathophysiology and Treatment of Allergy [in Russian], Moscow (1972), pp. 49–56.
V. G. Molotkov, Tr. Smolensk. Med. Inst.,25, 19 (1968).
I. K. Musabaev and F. Z. Abubakirova, Bacillary Dysentery [in Russian], Tashkent (1973), pp. 80–88.
D. M. Nedopryadko, in: Problems in the Prophylaxis, Diagnosis, and Treatment of Diseases of the Digestive Organs (Proceedings of a Republican Conference) [in Russian], Kiev (1969), pp. 180–181.
M. M. Khakberdyev and E. G. Lemeleva, in: Selected Scientific Transactions of Samarkand Medical Institute [in Russian], Vol. 37, Samarkand (1967), pp. 182–186.
I. Kharvat, Klin. Med., No. 1, 18 (1960).
V. A. Yusin, Tr. Smolensk. Med. Inst.,25, 55 (1968).
T. Emanuel, G. Elanhu, and W. Uzi, Brit. Med. J.,4, 741 (1968).
F. W. Smith, D. N. Law, W. F. Nickel, et al., Gastroenterology,42, 233 (1962).
J. Turiof, Rev. Prat.,10, 3143 (1960).
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Galsanov, S.B., Turova, A.D. & Klimenko, E.D. Effect of quercitrin on structural changes in the large and small intestine in experimental enterocolitis. Bull Exp Biol Med 81, 775–777 (1976). https://doi.org/10.1007/BF00797163
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DOI: https://doi.org/10.1007/BF00797163