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Interaction ofEscherichia coli cytotoxic necrotizing factor type 1 (CNF1) with cultured cells

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Abstract

The cytotoxic necrotizing factor type 1 (CNF1) fromE. coli causes necrosis in rabbit skin and multinucleation in cultured cells. Cells exposed to CNF1 were characterized by changes in actin organization, mainly consisting in the presence of well-developed stress fibers and membrane ruffles. The interaction of CNF1 with the cell cytoskeleton probably promotes the cell spreading and interferes with the cytokinesis, leading to the formation of giant multinucleated cells.

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Authors and Affiliations

  1. Department of Ultrastructures, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy

    L. Falzano, C. Fiorentini, P. Boquet & G. Donelli

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  1. L. Falzano
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  2. C. Fiorentini
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  3. P. Boquet
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  4. G. Donelli
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Falzano, L., Fiorentini, C., Boquet, P. et al. Interaction ofEscherichia coli cytotoxic necrotizing factor type 1 (CNF1) with cultured cells. Cytotechnology 11 (Suppl 1), S56–S58 (1993). https://doi.org/10.1007/BF00746055

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  • DOI: https://doi.org/10.1007/BF00746055

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