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Evidence for joint genic control of spontaneous mutation and genetic recombination during mitosis inSaccharomyces

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Summary

A procedure for detection of mutants exhibiting either enhanced or reduced spontaneous mutation during mitosis and/or meiosis has been developed to probe the joint genic control of spontaneous mutation and recombination in yeast. A semidominant mutator,rem1-1, recovered by this technique, exhibits enhanced spontaneous mutation, intragenic recombination, and intergenic recombination during mitosis. Diploids homozygous forrem1-1 exhibit normal levels of meiotic intragenic and intergenic recombination and diminished ascospore viability.

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Authors and Affiliations

  1. Erman Biology Center, Department of Biology, University of Chicago, Chicago, Illinois, USA

    John E. Golin & Michael S. Esposito

  2. Committee on Genetics, University of Chicago, Chicago, Illinois, USA

    John E. Golin & Michael S. Esposito

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  1. John E. Golin
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  2. Michael S. Esposito
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Communicated by F. Stahl

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Golin, J.E., Esposito, M.S. Evidence for joint genic control of spontaneous mutation and genetic recombination during mitosis inSaccharomyces . Molec. Gen. Genet. 150, 127–135 (1977). https://doi.org/10.1007/BF00695392

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  • DOI: https://doi.org/10.1007/BF00695392

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