Summary
The toxicity of d-tubocurarine in mice was slightly but significantly reduced after pretreatment with drugs which are known to increase the intracellular level of c-AMP. Papaverine, theophylline and ephedrine elevated the LD50 values of d-tubocurarine by 12 to 26%. The dibutyryl derivative of c-AMP as well as c-GMP were also active in this respect.
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References
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Anttila, P., Vapaatalo, H. Decreased toxicity of d-tubocurarine after pretreatment with drugs elevating the intracellular level of c-AMP in mice. Naunyn-Schmiedeberg's Arch. Pharmacol. 273, 175–178 (1972). https://doi.org/10.1007/BF00508090
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DOI: https://doi.org/10.1007/BF00508090