Summary
-
1.
Sodium warfarin, given by oral or by parenteral route, displays a pronounced antiinflammatory effect in the formaldehyde and carrageenan induced rat paw edema. This effect becomes patent not only when the warfarin application precedes the local injection of the irritant substance (prophylactic effect), but also when it is given to animals with already developed inflammatory reactions (therapeutic effect).
-
2.
The active doses of Na warfarin lie between 0.5 and 5.0 mg/kg. Smaller as well as higher doses show a reduced anti-inflammatory effect.
-
3.
A marked anti-inflammatory effect can be noted already 90 min after drug injection at a still normal prothrombin level.
-
4.
Vitamin K1 (phylloquinone), given by oral or parenteral route, in doses from 1.6 mg/kg upwards, shows a marked anti-inflammatory effect both in the prophylactic and the therapeutic rat paw test. Vitamin K3 is devoid of any anti-inflammatory activity.
-
5.
The anti-inflammatory effect of both sodium warfarin and of vitamin K1 in rats, is not interfered with by previous adrenalectomy.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
van Arman, C. G., Begany, A. J., Miller, L. M., Pless, H. H.: Some details of the inflammations caused by yeast and carrageenin. J. Pharmacol. Exp. Ther. 150, 328–334 (1965)
Berquó, E., Marques, R. M.: Analise de variância São Paulo: Cadeira de Estatística da Faculdade de Higiene e Saúde Pública 1964
Brodie, A. F.: Vitamin K and other quinones as coenzymes in oxidative phosphorylation in bacterial systems. Fed. Proc. 20, 995–1004 (1961)
D'Amour, F. E., Blood, F. R.: Manual for laboratory work in mammalian physiology. Chicago: The Univ. of Chicago Press 1961
Eichbaum, F.: Extraanticoagulant effects of oral anticoagulants. Arq. Bras. Cardiol. 286, 637–641 (1975a)
Eichbaum, F.: Anticoagulants and cancer, a review. Rev. Bras. Pesq. Med. e Biol. 85, 489–496 (1975b)
Fontaine, L., Grand, M., Molho, D. Z., Boschetti, E.: Activit e antiinflammatoire expérimentale de coumarines, indane-diones et acyl-indane-diones apparentées aux anticoagulants oraux. Med. Pharmacol. Exp. 17, 497–507 (1967)
Fontaine, L., Grand, M., Quintin, J., Merle, S.: Activité antiinflammatoire comparée de substances anticoagulantes. Mode d'action de la Phénylandanadione. Med. Pharmacol. Exp. 13, 137–154 (1965)
Fontaine, L., Odievre, M., Cachet, J., Drevon, B.: Pharmacologie de la phenyl-indanedione. Therapie XVI, 34–50 (1961)
Goldstein, A.: Biostatistics. New York: Macmillan 1967
Link, K. P., Overman, R. S., Sullivan, W. H., Huebner, C. F., Sheel, L. D.: Studies on the haemorrhagic sweet clover disease. XI. Hypoproteinaemia in the rat induced by salicylic acid. J. Biol. Chem. 147, 463–474 (1943)
Piller, N. B.: The resolution of thermal edema at various temperatures under coumarin treatment. Br. J. Exp. Pathol. 56, 83–91 (1975)
Piller, N. B.: Drug induced proteolysis: a correlation with edema reducing ability. Br. J. Exp. Pathol. 57, 266–273 (1976a)
Piller, N. B.: Comparison of the effect of benzopyrones and other drugs with anti-inflammatory properties on acid and neutral protease activity levels in various tissues after thermal injury. Br. J. Exp. Pathol. 57, 411–418 (1976b)
Piller, N. B.: The action of benzopyrones on an experimental model of lymphedema: a contribution to their mode of action. Br. J. Exp. Pathol. 57, 713–721 (1976c)
Piller, N. B.: Tissue levels of (3−14C) coumarin in the rat: distribution and excretion. Br. J. Exp. Pathol. 58, 28–34 (1977)
Quick, A. J.: The physiologic pharmacology of homeostasis, pp. 125–134. New York: Lea and Febiger 1951
v. Rechenberg, H. K. (ed.): Butazolidin, Phenylbutazon, pp. 32/33. Stuttgart: G. Thieme 1961
Renk, E., Stoll, W. G.: Orale Antikoagulantien. Fortschr. Arzneimittelforsch. 11, 226–355 (1968)
Thiers, H.: In. Les Vitamines, pp. 333–336. Paris: Masson 1956
Weiner, M., Shapiro, S., Axelrod, J., Cooper, J. R., Brodie, B. B.: The physiological disposition of dicoumarol in man. J. Pharmacol. Exp. Ther. 99, 409–420 (1950)
Wosilait, A. D.: Role of vitamin K in electron transport. Fed. Proc. 20, 1005–1011 (1961)
Yacobi, A., Wingard, L. B. jr., Levy, G.: Comparative pharmacocinetics of coumarin anticoagulants. X. Relationship between distribution and anticoagulant action of warfarin. J. Pharm. Sci. 63, 868–872 (1974)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Eichbaum, F.W., Slemer, O. & Zyngier, S.B. Anti-inflammatory effect of warfarin and vitamin K1 . Naunyn-Schmiedeberg's Arch. Pharmacol. 307, 185–190 (1979). https://doi.org/10.1007/BF00498462
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00498462