Abstract
Following repeated electroconvulsive shocks (ECS) (once daily for 10 days), rats display enhanced hyperactivity responses to tranylcypromine and l-tryptophan, a procedure which increases brain 5-hydroxytryptamine (5-HT) concentrations, or to the suggested 5-HT agonist quipazine. The enhanced responses last for about 6 days following the last shock. Repeated sub-convulsive shocks did not produce this behavioural enhancement.
Administration of indomethacin (2 mg/kg) 25 min before the ECS did not prevent the enhanced 5-HT response suggesting that the enhanced response is not the result of the reported rise in prostaglandins F following ECS.
Repeated ECS shortened the time to loss of righting following pentobarbital (50 mg/kg) but did not alter the total sleeping time.
Repeated ECS enhances locomotor activity produced by methamphetamine. It also enhances circling produced by methamphetamine and apomorphine in unilateral nigrostriatal lesioned rats, suggesting an enhanced postsynaptic response.
No evidence was found for ECS altering the response of striatal adenylate cyclase to dopamine nor for any alteration of striatal cyclic AMP concentration.
These data taken with our previous study reinforce the suggestion that electroconvulsive therapy (ECT) produces increased responses to 5-hydroxytryptamine and dopamine receptor stimulation.
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Breese, G. R., Cott, J. M., Cooper, B. R., Prange, A. J., Lipton, M. A., Plotnikoff, N. P.: Effects of thyrotropin releasing hormone (TRH) on the actions of pentobarbital and other centrally acting drugs. J. Pharmacol. exp. Ther. 193, 11–22 (1975)
Brown, B. L., Albano, J. D. M., Ekins, R. P., Sgherzi, A. M., Tamplion, W.: A simple and sensitive saturation assay method for the measurement of adenosine 3′5′ cyclic monophosphate. Biochem. J. 121, 561–562 (1971)
Cronhelm, B., Ottosson, J.-O.: Experimental studies of the therapeutic action of electroconvulsive therapy in endogenous depression. Acta psychiat. scand., Suppl. 145, 69–97 (1960)
Evans, J. P. M., Grahame-Smith, D. G., Green, A. R., Tordoff, A. F. C.: Electroconvulsive shock increases the behavioural responses of rats to brain 5-hydroxytryptamine accumulation and central nervous system stimulant drugs. Brit. J. Pharmacol. 56, 193–199 (1976)
Grahame-Smith, D. G.: Studies in vivo on the relationship between brain tryptophan, brain 5-HT synthesis and hyperactivity in rats treated with a monoamine oxidase inhibitor and l-tryptophan. J. Neurochem. 18, 1053–1066 (1971)
Green, A. R., Bloomfield, M. R., Tordoff, A. F. C.: Elevation of brain GABA concentrations with amino-oxyacetic acid; effect on the hyperactivity syndrome produced by increased 5-hydroxy-tryptamine synthesis in rats. J. Neural. Transm. 39, 103–112 (1976a)
Green, A. R., Grahame-Smith, D. G.: The role of brain dopamine in the hyperactivity syndrome produced by increased 5-hydroxy-tryptamine synthesis in rats. Neuropharmacology 13, 949–959 (1974a)
Green, A. R., Grahame-Smith, D. G.: TRH potentiates behavioural changes following increased brain 5-hydroxytryptamine accumulation in rats. Nature (Lond.) 251, 524–526 (1974b)
Green, A. R., Grahame-Smith, D. G.: Effects of drugs on the processes regulating the functional activity of brain 5-hydroxytryptamine. Nature (Lond.) 260, 487–491 (1976)
Green, A. R., Heal, D. J., Grahame-Smith, D. G., Kelly, P. H.: The contrasting actions of TRH and cycloheximide in altering the effects of centrally acting drugs: evidence for the noninvolvement of dopamine sensitive adenylate cyclase. Neuropharmacology 15, 591–599 (1976b)
Green, A. R., Kelly, P. H.: Evidence concerning the involvement of 5-hydroxytryptamine in the locomotor activity produced by amphetamine or tranylcypromine plus l-Dopa. Brit. J. Pharmacol. 57, 141–147 (1976)
Green, A. R., Youdim, M. B. H., Grahame-Smith, D. G.: Quipazine: its effects on rat brain 5-hydroxytryptamine metabolism, monoamine oxidase activity and behaviour. Neuropharmacology 15, 173–179 (1976c)
Kebabian, J. W., Petzold, G. L., Greengard, P.: Dopamine-sensitive adenylate cyclase in the caudate nucleus of the rat brain and its similarity of the “dopamine receptor”. Proc. nat. Acad. Sci. (Wash.) 69, 2145–2149 (1972)
Kelly, P. H.: Unilateral 6-hydroxydopamine lesions of nigrostriatal or mesolimbic dopamine-containing terminals and drug induced rotation in rats. Brain Res. 100, 163–169 (1975)
Kelly, P. H., Seviour, P. W., Iversen, S. D.: Amphetamine and apomorphine responses in the rat, 6-OHDA lesions of the nucleus acumbens septi and corpus striatum. Brain Res. 94, 507–522 (1975)
Modigh, K.: Electroconvulsive shock and post-synaptic catecholamine effects: Increased psychomotor stimulant action of apomorphine and clonidine in reserpine pretreated mice by repeated ECS. J. Neural. Transm. 36, 19–32 (1975)
Modigh, K.: Long-term effects of electroconvulsive shock therapy on synthesis turnover and uptake of brain monoamines. Psychopharmacology 49, 179–185 (1976)
Pellegrino, L. J., Cushman, A. J.: A stereotaxic atlas of the rat brain, New York: Appleton-Century-Crofts 1967
Prange, A. J., Breese, G. R., Cott, J. R., Martin, B. R., Cooper, B. R., Wilson, I. L., Plotnikoff, N. P.: Thyrotropin releasing hormone: Antagonism of pentobarbital in rodents. Life Sci. 14, 447–455 (1974)
Rodríguez, R., Rojas-Ramirez, J. A., Drucker-Colin, R. R.: Serotonin-like actions of quipazine on the central nervous system. Europ. J. Pharmacol. 24, 164–171 (1973)
Ungerstedt, U.: Striatal dopamine release after amphetamine or nerve degeneration revealed by rotational behaviour. Acta physiol. Scand. 83, Suppl. 367, 49–68 (1971)
Zatz, M., Roth, R. H.: Electroconvulsive shock raises prostaglandins F in rat cerebral cortex. Biochem. Pharmacol. 24, 2101–2103 (1975)
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Green, A.R., Heal, D.J. & Grahame-Smith, D.G. Further observations on the effect of repeated electroconvulsive shock on the behavioural resposes of rats produced by increases in the functional activity of brain 5-hydroxytryptamine and dopamine. Psychopharmacology 52, 195–200 (1977). https://doi.org/10.1007/BF00439110
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DOI: https://doi.org/10.1007/BF00439110