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Diurnal rhythm of mitosis in rabbit corneal epithelium

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Abstract

Incorporation of 3H-thymidine by rabbit corneal epithelium during the course of a one-hour incubation in vitro varies according to the time of day, suggesting a diurnal rhythm of mitotic activity. Adrenergic decentralization of the cornea does not affect this rhythm. Furthermore, there is no diurnal variation in the basal or sympathomimetically-stimulated cyclic AMP production by freshly excised rabbit corneas, incubated in vitro. Therefore, the diurnal rhythm of corneal epithelial mitosis in the rabbit is not paced by catecholamines.

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Authors and Affiliations

  1. The Eye Research Institute of Retina Foundation and the Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA

    J. A. Fogle, B. K. Yoza & A. H. Neufeld

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  1. J. A. Fogle
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  2. B. K. Yoza
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  3. A. H. Neufeld
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Additional information

This work was supported by United States Public Health Service Grants EY-02360 and EY-02367, Biomedical Research Support Grant 5SO7RR05527, and the Massachusetts Lions Eye Research Fund, Inc. Dr. Neufeld is the recipient of Research Career Development Award EY-00114. Dr. Fogle is the recipient of a Bausch and Eomb External Disease Fellowship and a Heed Foundation Fellowship Award

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Fogle, J.A., Yoza, B.K. & Neufeld, A.H. Diurnal rhythm of mitosis in rabbit corneal epithelium. Albrecht von Graefes Arch. Klin. Ophthalmol. 213, 143–148 (1980). https://doi.org/10.1007/BF00410983

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  • DOI: https://doi.org/10.1007/BF00410983

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