Abstract
Aggressive behaviors during the withdrawal from morphine sulfate (400 mg/kg/day), were potentiated by methylphenidate or d and l isomers of amphetamine. d-Amphetamine was most active, while hydroxyamphetamine was without any effect. Optimum effect of the drugs depended upon the drug dose and the time of morphine withdrawal.
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References
Barnett, S. A.: Rats. Sci. Amer. 216, 78–85 (1967).
—: The rat. A study in behavior, pp. 79–89. Chicago: Aldine 1963.
Boshka, S. C., Weisman, H. M., Thor, D. H.: A technique for inducing aggression in rats utilizing morphine withdrawal. Psychol. Rec. 16, 541–543 (1966).
Darwin, C.: Expression of the emotions in man and animals. London: Murray 1873.
Eibl-Eibesfeldt, I.: The fighting behavior of animals. Sci. Amer. 205, 112–122 (1961).
Lal, H.: Operant control of vocal responding in rats. Psychon. Sci. 8, 35–36 (1967).
—, DeFeo, J. J., Thut, P.: Effect of amphetamine on pain induced aggression. Commun. Behav. Biol., Part A 1, 333–336 (1968).
—, Nesson, B., Smith, N.: Amphetamine-Induced aggression in mice pretreated with dihydroxyphenylalanine (DOPA) and/or reserpine. Biol. Psychiat. 2, 299–301 (1970).
Martin, W. R., Wikler, A., Eades, C. G., Pescor, F. T.: Tolerance to and physical dependence on morphine in rats. Psychopharmacologia (Berl.) 4, 247–260 (1963).
Randrup, A., Munkvad, I.: Relation of brain catecholamines to aggressiveness and other forms of behavioural excitation: Aggressive behavior, pp. 228–235. S. Garrattini and E. B. Sigg, ed. New York: John Wiley 1969.
Task Force on Narcotics and Drug Abuse: The president's commission on law enforcement nd administration of justice. Task Force Reports on Narcotics and Drug, Abuse. U.S. Government Printing Office, Washington, D.C. 1967.
Taylor, K. M., Snyder, S. H.: Amphetamine: Differentiation by d and 1 isomers of behavior involving brain norepinephrine or dopamine. Science 168, 1487 to 1489 (1970).
Thor, D. H.: Amphetamine induced fighting during morphine withdrawal. J. gen. Psychol. 84, 245–250 (1971).
—: Chemical induction of traumatic fighting behavior. Proc. Amer. Psychol. Ass. 4 (Part II), 883–884 (1969).
—, Hoats, D. L.: Morphine-amphetamine-induced fighting and interim socialization. Psychon. Sci. 20, 156–158 (1970).
Ulrich, R. E., Azrin, N. H.: Reflexive fighting in response to aversive stimulation. J. exp. Anal. Behav. 5, 511–520 (1962).
Yen, C. Y., Stanger, R. L., Millman, N.: Atartic suppression of isolation induced aggression behavior. Arch. int. Pharmacodyn. 123, 179–185 (1959).
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Lal, H., O'brien, J. & Puri, S.K. Morphine-withdrawal aggression: Sensitization by amphetamines. Psychopharmacologia 22, 217–223 (1971). https://doi.org/10.1007/BF00401783
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DOI: https://doi.org/10.1007/BF00401783