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Circulating met-enkephalin in trained athletes during rest, exhaustive treadmill exercise and marathon running

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Summary

Twelve trained male athletes were subjected to a progressive intensity treadmill exercise test to total exhaustion and at a later date took part in the Comrades Marathon. Blood was taken in order to determine whether plasma met-enkephalin levels increase in an exercise-intensity dependent manner.

The mean concentrations in f mol/ml were as follows: post-exercise levels (266) were significantly higher than basal levels (172), and the post-marathon levels (378) rose significantly above the post-exercise levels.

The magnitude of the responses is thus correlated with the amount of work performed and would suggest that this opioid peptide is involved in physiological actions that perhaps extend beyond the pharmacological actions of opiate drugs.

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References

  • Colt EW, Wardlaw SL, Frantz AG (1981) The effect of running on plasma beta-endorphin. Life Sci 28: 1637–1640

    Google Scholar 

  • Dearman J, Francis KT (1983) Plasma levels of catecholamines, cortisol and beta-endorphins in male athletes after running 26.2, 6 and 2 miles. J Sports Med 23: 30–38

    Google Scholar 

  • Friaioli F, Moretti C, Paolucci D, Alicicco E, Crescenzi F, Fortunio G (1980) Physical exercise stimulates marked concomitant release of beta-endorphin and adrenocorticotropic hormone (ACTH) in peripheral blood in man. Experientia 36: 987–989

    Google Scholar 

  • Howlett TA, Tomlin S, Ngahfoong L, Rees LH, Bullen BA, Skrinar GS, McArthur JW (1984) Release of β-endorphin and metenkephalin during exercise in normal women: response to training. Br Med J 288: 1950–1952

    Google Scholar 

  • Noakes T (1986) The lore of running. Oxford University Press, Cape Town, pp 7–10

    Google Scholar 

  • Nyberg F, Christensson-Nylander I, Terenius L (1987) Measurement of opioid peptides in biologic fluids by radioimmunoassay. In: Patrono C, Peskar BA (eds) Handbook of experimental pharmacology, vol 82. Springer, Berlin Heidelberg New York, pp 227–253

    Google Scholar 

  • Sommers De K, Simpson SF, Loots JM, Meyer EC, Dettweiler A, Daehne HO (1989) Met-enkephalin release during exercise in unfit and superfit individuals. Eur J Clin Pharmacol 37: 399–400

    Google Scholar 

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De Sommers, K., Loots, J.M., Simpson, S.F. et al. Circulating met-enkephalin in trained athletes during rest, exhaustive treadmill exercise and marathon running. Eur J Clin Pharmacol 38, 391–392 (1990). https://doi.org/10.1007/BF00315582

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  • DOI: https://doi.org/10.1007/BF00315582

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