Summary
In three women with a 46,XXq- chromosome constitution, the length of the deletion was expressed as the ratio of the remaining part of Xq to Xp \(\frac{{c'}}{{a + b}}\). In one of them (KH) this ratio was 0.33, in another (GE) 0.59, and in the third (AP) the ratio fell between these values. The break in KH is more or less on the border of the Q-dark proximal region. A comparison with relevant X-autosomal translocations indicates that the X inactivation center lies near, but not at the border of, the Q-dark and the adjoining bright region (c and d).
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Allderdice, P. W., Miller, O. J., Miller, D. A., Klinger, H. P.: Spreading of inactivation in an (X;14) translocation. Am. J. Med. Genet. (in press, 1979)
Chapelle, A. de la, Schröder, J.: Reappraisal of a 46,X,i(Xp) karyotype as 46,X,del(Xq). Hereditas 80, 137–140 (1975)
Leisti, J. T., Kaback, M. M., Rimoin, D. L.: Human X-autosome translocations: Differential inactivation of the X chromosome in a kindred with an X-9 translocation. Am J. Hum. Genet. 27, 441–453 (1975)
Sarto, G. E., Therman, E., Patau, K.: X inactivation in man: A woman with t(Xq-;12q+). Am. J. Hum. Genet. 25, 262–270 (1973)
Summitt, R. L., Martens, P. R., Wilroy, R. S. Jr.: X-autosome translocation in normal mother and effectively 21-monosomic daughter. J. Pediatr. 84, 539–546 (1974)
Summitt, R. L., Tipton, R. E., Wilroy, R.S. Jr., Martens, P. R., Phelan, J. P.: X-autosome translocations: A review. Birth Defects 14, (6C), 219–247 (1978)
Therman, E., Patau, K.: Abnormal X chromsomes in man: Origin, behavior and effects. Humangenetik 25, 1–16 (1974)
Therman, E., Sarto, G. E., Patau, K.: Center for Barr body condensation on the proximal part of the human Xq: A hypothesis. Chromosoma 44, 361–366 (1974)
Therman, E., Sarto, G. E., Distèche, C., Denniston, C.: A possible active segment on the inactive human X chromosome. Chromosoma 59, 137–145 (1976)
Yunis, J. J., Sawyer, J. R., Ball, D. W.: The characterization of high-resolution G-banded chromosomes of man. Chromosoma 67, 293–307 (1978)
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Therman, E., Sarto, G.E., Palmer, C.G. et al. Position of the human X inactivation center on Xq. Hum Genet 50, 59–64 (1979). https://doi.org/10.1007/BF00295590
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DOI: https://doi.org/10.1007/BF00295590