Abstract
Dynamic positron emission tomography (PET) of the liver tumor was performed with a whole body multi slice PET device and 13N-ammonia. Sixteen patients with hepatocellular carcinoma (HCC) and seven patients with metastatic liver tumor were studied. In 12 of 16 patients with HCC, in which cases rich tumor vessels and dense tumor stain were proven by hepatic angiography, the tumors showed remarkable uptake of 13N-ammonia from the first scan, whereas the radionuclide accumulation was more gradual in the other part of the liver, and high tumor to liver ratio (T/L ratio) (2.62±1.09) was observed in the 1st scan, so that the tumor was clearly visualized by high contrast. However, HCC with poor blood supply from the hepatic artery or central necrosis of the tumor were demonstrated as low T/L ratio. In seven cases with metastatic liver tumor, the accumulation of 13N-ammonia was also lower than the normal liver throughout the scan. The results suggested that hepatic arterial blood flow of the liver tumors can be assessed with dynamic PET, which may provide valuable information for the characterization of tumors as well as for the evaluation of the treatment.
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References
Bergmann SR, Hack S, Tewson T, Welch MJ, Sobel BE (1980) The dependence of accumulation of 13NH3 by myocardium on metabolic factors and its implications for quantitative assessment of perfusion. Circulation 61:34–43
Fukuda N, Tateno Y, Rikitake T, Matsumoto T, Tomitani T, Suzuki K, Koen H, Musha H, Okuda K (1977) Coinsidence positron imaging of the liver and heart following rectal administration of 13N-ammonia in liver cirrhosis. Radioisotope 26:872–875
Hayashi N, Tamaki N, Yonekura Y, Senda M, Saji H, Yamamoto K, Konishi J, Torizuka K (1985) Imaging of the hepatocellular carcinoma using dynamic positron emission tomography with Nitrogen-13 ammonia. J Nucl Med 26:254–257
Lockwood AH, Mcdonald JM, Reiman RE, Gelbard AS, Laughlin JS, Duffy TE, Plum F (1979) The dynamics of ammonia metabolism in man, Effects of liver disease and hyperammonemia. J Clin Invest 63:449–460
Nakamura H, Tanaka T, Hori S, Yoshikawa H, Kuroda C, Okamura J, Sakurai M (1983) Transcatheter embolization of hepatocellular carcinoma: assessment of efficiancy in cases of resection following embolization. Radiology 147:401–405
Ohishi H, Uchida H, Yoshimura H, Ohue S, Ueda J, Katsuragi M, Matsuo N, Hosogi Y (1985) Hepatocellular carcinoma detected by iodized oil. Radiology 154:25–29
Phelps ME, Hoffman EJ, Coleman RE, Welch MJ, Raichle ME, Weiss ES, Sobel BE, Ter-Pogossian MM (1976) Tomographic images of blood pool and perfusion in brain and heart. J Nucl Med 17:603–612
Phelps ME, Huang SC, Hoffman EJ, Selin C, Kuhl DE (1981) Cerebral extraction of N-13 ammonia: its dependence on cerebral blood flow and capillary permeability—surface area product. Stroke 12:607–619
Schelbert HR, Phelps ME, Haung SC, Macdonald NS, Hansen H, Selin C, Kuhl DE (1981) N-13 ammonia as an indicator of myocardial blood flow. Circulation 63:1259–1272
Schelstraete K, Simons M, Deman J, Vermeulen FL, Slegers G, Vandecasteele C, Goethals P, De Schryver A (1982) Uptake of 13N-ammonia by human tumors as studied by positron emission tomography. Br J Radiol 55:797–804
Senda M, Tamaki N, Yonekura Y, Tanada S, Murata K, Hayshi N, Fujita T, Saji H, Konishi J, Torizuka K, Ishimatsu K, Takami K, Tanaka E (1985) Performance characteristics of positologica; A whole-body positron emission tomograph. J Comput Assist Tomogr 9:940–946
Tamaki N, Senda M, Yonekura Y, Saji H, Kodama S, Konishi Y, Ban T, Kambara H, Kawai C (1985) Dynamic positron computed tomography of the heart with a high sensitivity positron camera and nitrogen-13 ammonia. J Nucl Med 26:567–575
Yamada R, Sato M, Kawabata M, Nakatsuka H, Nakamura K, Takashima S (1983) Hepatic artery embolization in 120 patients with unresectable hepatoma. Radiology 148:397–401
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Shibata, T., Yamamoto, K., Hayashi, N. et al. Dynamic positron emission tomography with 13N-ammonia in liver tumors. Eur J Nucl Med 14, 607–611 (1988). https://doi.org/10.1007/BF00251784
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DOI: https://doi.org/10.1007/BF00251784