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Organization of climbing fiber input from mechanoreceptors to lobule V vermal cortex of the cat

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Summary

The somatotopic organization of the climbing fiber (CF) projections to the vermal cortex of lobule V of the cat was revealed by low threshold natural stimulation of mechanoreceptors. Extracellular single-unit recordings were made from 554 Purkinje cells in cats anesthetized with sodium pentobarbital. Forty-nine percent of the CF responses were elicited by cutaneous stimulation of the forelimb (62%), hindlimb (25%), or upper back and neck (13%). The topographical arrangement consisted of a 1 mm wide medial zone and a 1–1.5 mm wide lateral zone. In the medial zone, the CF responses were mainly nonresponsive to any cutaneous stimulation except in the caudomedial portion of the lobule where the upper back, neck or ears were represented in a narrow parasagittally oriented strip. The lateral zone contained a mixture of CF responses representing projections from different portions of the ipsilateral forelimb and hindlimb. Although CF responses connected with the forepaw or hindpaw predominated throughout all parts of the lateral zone, the more medial portions of this zone contained larger receptive fields involving the more proximal areas of the limb whereas the lateral part of the zone had smaller receptive fields representing the distal regions, particularly the ventral forepaw surface. Cells with similar receptive fields were often grouped together, but adjacent skin areas were not necessarily represented in adjacent cortical patches. Thus, the cutaneous projections to this lobule terminated in a patchy or mosaic fashion.

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References

  • Andersson G, Oscarsson O (1978) Climbing fiber microzones in cerebellar vermis and their projection to different groups of cells in the lateral vestibular nucleus. Exp Brain Res 32: 565–579

    PubMed  CAS  Google Scholar 

  • Armstrong DM, Harvey RJ, Schild RF (1974) Topographical localization in the olivocerebellar projection: An electrophysiological study in the cat. J Comp Neurol 154: 287–302

    Article  PubMed  CAS  Google Scholar 

  • Berthoz A, Llinás R (1974) Afferent neck projection to the cat cerebellar cortex. Exp Brain Res 20: 385–401

    Article  PubMed  CAS  Google Scholar 

  • Bloedel JR, Roberts WJ (1969) Functional relationship among neurons of the cerebellar cortex in the absence of anesthesia. J Neurophysiol 32: 75–84

    PubMed  CAS  Google Scholar 

  • Boylls CC (1980) Contributions to locomotor coordination of an olivo-cerebellar projection to the vermis in the cat: Experimental results and theoretical proposals. In: Courville J (ed) The inferior olivary nucleus: Anatomy and physiology. Raven Press, New York, pp 321–348

    Google Scholar 

  • Brand S, Dahl AL, Mugnaini E (1976) The length of parallel fibers in the cat cerebellar cortex. An experimental light and electron microscope study. Exp Brain Res 26: 39–58

    PubMed  CAS  Google Scholar 

  • Brodal A, Courville J (1973) Cerebellar corticonuclear projection in the cat. Crus IL An experimental study with silver methods. Brain Res 50: 1–23

    Article  PubMed  CAS  Google Scholar 

  • Courville J (1975) Distribution of olivocerebellar fibers demonstrated by a radioautographic tracing methods. Brain Res 95: 253–263

    Article  PubMed  CAS  Google Scholar 

  • Courville J, Diakiw N (1976) Cerebellar corticonuclear projection in the cat. The vermis of the anterior and posterior lobes. Brain Res 110: 1–20

    Article  PubMed  CAS  Google Scholar 

  • Denoth F, Magherini PC, Pompeiano O, Stanojevic M (1980) Responses of Purkinje cells of cerebellar vermis to sinusoidal rotation of neck. J Neurophysiol 43: 46–59

    PubMed  CAS  Google Scholar 

  • Eager A (1963) Efferent corticonuclear pathways in the cerebellum of the cat. J Comp Neurol 120: 81–104

    Article  Google Scholar 

  • Eccles JC, Faber DS, Murphy JT, Sabah NH, Táboříková (1971) Afferent volleys in limb nerves influencing impulse discharges in cerebellar cortex. II: Purkinje cells. Exp Brain Res 13: 54–77

    Article  Google Scholar 

  • Eccles JC, Provini L, Strata P, Táboříková H (1968) Topographical investigations on the climbing fiber inputs from forelimb and hindlimb afferents to the cerebellar anterior lobe. Exp Brain Res 6: 195–215

    Article  PubMed  CAS  Google Scholar 

  • Ekerot CF, Larson B (1979) The dorsal spino-olivocerebellar system in the cat. I. Functional organization and termination in the anterior lobe. Exp Brain Res 36: 201–217

    Article  PubMed  CAS  Google Scholar 

  • Fox CA, Barnard JW (1957) A quantitative study of the Purkinje cell dendrite branchlets and their relationship to afferent fibers. J Anat 91: 299–313

    PubMed  CAS  Google Scholar 

  • Gilbert PFC, Thach WT (1977) Purkinje cell activity during motor learning. Brain Res 128: 621–638

    Article  Google Scholar 

  • Groenewegen HJ, Voogd J (1977) The parasagittal zonation within the olivocerebellar projection. I. Climbing fiber distribution in the vermis of cat cerebellum. J Comp Neurol 174: 417–488

    Article  PubMed  CAS  Google Scholar 

  • Groenewegen HJ, Voogd J, Freedman SL (1979) The parasagittal zonation within the olivocerebellar projection. II. Climbing fiber distribution in the intermediate and hemispheric part of cat cerebellum. J Comp Neurol 183: 551–601

    Article  PubMed  CAS  Google Scholar 

  • Haines DE (1976) Cerebellar corticonuclear and corticovestibular fibers of the anterior lobe vermis in a prosimian primate (Galago senegalensis). J Comp Neurol 170: 67–96

    Article  PubMed  CAS  Google Scholar 

  • Haines DE, Ruberton JA (1979) Cerebellar corticonuclear fibers of the dorsal culminate lobe (anterior lobe-lobule V) in a prosimian primate, Galago senegalensis. J Comp Neurol 186: 321–342

    Article  PubMed  CAS  Google Scholar 

  • Hiss E, Leicht R, Schmidt RF (1977) Cutaneous receptive fields of cerebellar Purkinje cells of unanesthetized cats. Exp Brain Res 27: 319–333

    PubMed  CAS  Google Scholar 

  • Ishikawa K, Kawaguchi S, Rowe MJ (1972) Actions of afferent impulses from muscle receptors on cerebellar Purkinje cells. II. Responses to muscle contraction: Effects mediated via the climbing fiber pathway. Exp Brain Res 16: 104–114

    Article  PubMed  CAS  Google Scholar 

  • Joseph JW, Shambes GM, Gibson JM, Welker W (1978) Tactile projections to granule cells in caudal vermis of the rat's cerebellum. Brain Behav Evol 15: 141–149

    Article  PubMed  CAS  Google Scholar 

  • Kitai ST, Táboříková H, Tsukahara N, Eccles JC (1969) The distribution to the cerebellar anterior lobe of the climbing and mossy fiber inputs from the plantar and palmar cutaneous afferents. Exp Brain Res 7: 1–10

    Article  PubMed  CAS  Google Scholar 

  • Larsell O, Jansen J (1970) The comparative anatomy and histology of the cerebellum from monotremes through apes. University of Minnesota Press, Minneapolis

    Google Scholar 

  • Larson B, Miller S, Oscarsson O (1969a) Termination and functional organization of the dorsolateral spino-olivocerebellar path. J Physiol (Lond) 203: 611–640

    CAS  Google Scholar 

  • Larson B, Miller S, Oscarsson O (1969b) A spinocerebellar climbing fiber path activated by the flexor reflex afferents from all four limbs. J Physiol (Lond) 203: 641–649

    CAS  Google Scholar 

  • Lathem A, Paul DH (1971) Effects of sodium thiopentone on cerebellar neuronal activity. Brain Res 25: 212–215

    Article  Google Scholar 

  • Leicht R, Rowe MJ, Schmidt RF (1977) Mossy and climbing inputs from cutaneous mechanoreceptors to cerebellar Purkinje cells in unanesthetized cats. Exp Brain Res 27: 459–477

    PubMed  CAS  Google Scholar 

  • Leicht R, Schmidt RF (1977) Somatotopic studies on the vermal cortex of the cerebellar anterior lobe of unanesthetized cats. Exp Brain Res 27: 479–490

    PubMed  CAS  Google Scholar 

  • Llinás R, Hillman DE (1969) Physiologic and morphological organization of the cerebellar circuits in various vertebrates. In: Llinás R (ed) Neurobiology of cerebellar evolution and development. American Medical Association, Chicago, pp 43–73

    Google Scholar 

  • Mackay WA, Murphy JT (1980) Cerebellar modulation of reflex gain. Prog Neurobiol 13: 361–417

    Article  Google Scholar 

  • Mano NI (1974) Simple and complex spike activities of the cerebellar Purkinje cell in relation to selective alternate movements in intact monkey. Brain Res 70: 381–393

    Article  PubMed  CAS  Google Scholar 

  • McElligott JG (1976) Cerebellar neuronal firing patterns in the intact and unrestrained cat and during walking. In: Herman RM, Grillner S, Slein PSG, Stuart DG (eds) Neural control of locomotion. Plenum Press, New York, pp 781–784

    Google Scholar 

  • Miles TS, Wiesendanger M (1975) Climbing fiber inputs to cerebellar Purkinje cells from trigeminal cutaneous afferents and the SI face area of the cerebral cortex in the cat. J Physiol (Lond) 245: 425–445

    CAS  Google Scholar 

  • Mortimer JA (1975) Cerebellar responses to teleceptive stimuli in alert monkeys. Brain Res 83: 369–390

    Article  PubMed  CAS  Google Scholar 

  • Murphy JT, MacKay WA, Johnson F (1973) Differences between cerebellar mossy and climbing fiber responses to natural stimulation of forelimb muscle proprioceptors. Brain Res 55: 263–289

    Article  PubMed  CAS  Google Scholar 

  • Oscarsson O (1969) The sagittal organization of the cerebellar anterior lobe as revealed by the projection patterns of the climbing fiber system. In: Llinás R (ed) Neurobiology of cerebellar evolution and development. American Medical Association, Chicago, pp 525–537

    Google Scholar 

  • Oscarsson O (1976) Spatial distribution of mossy and climbing fiber inputs into the cerebellar cortex. Exp Brain Res [Suppl] 1: 36–42

    Google Scholar 

  • Oscarsson O, Sjolund B (1977a) The ventral spino-olivocerebellar system in the cat. I. Identification of five paths and their termination in the cerebellar anterior lobe. Exp Brain Res 28: 469–486

    PubMed  CAS  Google Scholar 

  • Oscarsson O, Sjolund B (1977b) The ventral spino-olivocerebellar system in the cat. III. Functional characteristics of five paths. Exp Brain Res 28: 505–520

    PubMed  CAS  Google Scholar 

  • Provini L, Redman S, Strata P (1968) Mossy and climbing fiber organization on the anterior lobe of the cerebellum activated by forelimb and hindlimb areas of the sensory motor cortex. Exp Brain Res 6: 216–233

    Article  PubMed  CAS  Google Scholar 

  • Robertson LT, Laxer KD (1981) Localization of cutaneously elicited climbing fiber responses in lobule V of the monkey cerebellum. Brain Behav Evol 18: 157–168

    Article  PubMed  CAS  Google Scholar 

  • Rushmer DS, Roberts WJ, Augter GK (1976) Climbing fiber responses of cerebellar Purkinje cells to passive movement of the cat forepaw. Brain Res 106: 1–20

    Article  PubMed  CAS  Google Scholar 

  • Rushmer DS, Woollacott MH, Robertson LT, Laxer KD (1980) Somatotopic organization of climbing fiber projections from low threshold cutaneous afferents to pars intermedia of cerebellar cortex in the cat. Brain Res 181: 17–30

    Article  PubMed  CAS  Google Scholar 

  • Sasaki K, Oka H, Kawaguchi S, Jinnai K, Yasuda T (1977) Mossy fiber and climbing fiber responses produced in the cerebellar cortex by stimulation of the cerebral cortex in monkeys. Exp Brain Res 29: 419–428

    PubMed  CAS  Google Scholar 

  • Shambes GM, Gibson JM, Welker W (1978) Fractured somatotopy in granule cell tactile areas of rat cerebellar hemispheres revealed by micromapping. Brain Behav Evol 15: 94–140

    Article  PubMed  CAS  Google Scholar 

  • Slimp JC, Towe AL (1977) Characteristics of somatic receptive fields of neurons in postcruciate cerebral cortex in awake-restrained and two anesthetic conditions. Soc Neurosci Abstr 3: 492

    Google Scholar 

  • Snider RS, Stowell AA (1944) Receiving areas of tactile, auditory and visual systems in the cerebellum. J Neurophysiol 7: 331–358

    Google Scholar 

  • Thach WT (1970) Discharge of cerebellar neurons related to two maintained postures and two prompt movements. II. Purkinje cell output and input. J Neurophysiol 33: 537–547

    PubMed  CAS  Google Scholar 

  • Voogd J (1969) The importance of fiber connections in the comparative anatomy of the mammalian cerebellum. In: Llinás R (ed) Neurobiology of cerebellar evolution and development. American Medical Association, Chicago, pp 493–514

    Google Scholar 

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Authors and Affiliations

  1. Neurological Sciences Institute, 1120 NW 20th Avenue, 97209, Portland, OR, USA

    L. T. Robertson PhD, K. D. Laxer & D. S. Rushmer

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  1. L. T. Robertson PhD
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  2. K. D. Laxer
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  3. D. S. Rushmer
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Supported by NIH grant S-R01-NS-02289

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Robertson, L.T., Laxer, K.D. & Rushmer, D.S. Organization of climbing fiber input from mechanoreceptors to lobule V vermal cortex of the cat. Exp Brain Res 46, 281–291 (1982). https://doi.org/10.1007/BF00237186

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