Summary
Cells storing pancreatic polypeptide (PP) appear in rat pancreas at the time of parturition, much later than insulin and glucagon cells. At this stage, the pancreatic polypeptide (PP) cells occur scattered in the exocrine parenchyma and in the islets. Subsequently, 5–7 days postnatally, an abrupt increase in the number of PP cells occurs. At this stage, they are fairly numerous in the islets and comparatively rare in the exocrine parenchyma. Not until 8–10 days after birth is the number of PP cells similar to that in the adult pancreas. A few PP cells were seen in the antral mucosa during the first 10 days after birth. They were not seen elsewhere in the gut.
Similar content being viewed by others
References
Björklund, A., Falck, B., Owman, Ch.: Fluorescence microscopic and microspectrofluorometric techniques for the cellular localization and characterization of biogenic monoamines. In: Berson, S.A. (ed.), Methods of investigative and diagnostic endocrinology, Vol. 1. J.E. Rall and I.J. Kopin (eds). The thyroid and biogenic amines, pp. 318–368. Amsterdam: North-Holland Publ. Comp. 1972
Chance, R.E., Johnson, M.G., Koffenberger, J.E., Jr., Jones, W.E.: Unpublished observations
Erlandsen, S.L., Hegre, O.D., Parsons, J.A., McEvoy, R.C., Elde, R.P.: Pancreatic islet cell hormones. Distribution of cell types in the islets and evidence for the presence of somatostatin and gastrin within the D cell. J. Histochem. Cytochem. 24, 883–897 (1976)
Floyd, J.C., Jr., Chance, R.E., Hayashi, M., Moon, N., Fajans, S.S.: Concentrations of a newly recognized pancreatic islet polypeptide in plasma of healthy subjects and in plasma and tumors of patients with insulin-secreting tumors. Clin. Res. 23, 535A (1975)
Freie, H.M.P., Pasma, A., Bouman, P.R.: Quantitative analysis of pancreatic islet development and insulin storage in the foetal and newborn rat. Acta endocr. (Kbh.) 80, 657–666 (1975)
Frye, B.E.: The differentiation of the endocrine pancreas in fetuses of alloxan-diabetic and insulintreated rats. J. Morph. 101, 325–335 (1957)
Grillo, T.A.I., The occurrence of insulin in the pancreas of foetuses of some rodents. J. Endocr. 31, 67–73 (1964)
Kimmel, J.R., Hayden, L.J., Pollock, H.G.: Isolation and characterization of a new pancreatic polypeptide hormone, J. biol. Chem. 250, 9369–9376 (1975)
Kimmel, J.R., Pollock, H.G., Hazelwood, R.L.: Isolation and characterization of chicken insulin. Endocrinol. 83, 1323–1330 (1968)
Langslow, D.R., Kimmel, J.R., Pollock, H.G.: Studies on the distribution of a new avian pancreatic polypeptide and insulin among birds, reptiles, amphibians and mammals. Endocrinol. 93, 558–565 (1973)
Larsson, L.-I., Rehfeld, J.F., Sundler, F., Håkanson, R., Pancreatic gastrin in foetal and neonatal rats. Nature (Lond.) 262, 609–610 (1976a)
Larsson, L.-I., Sundler, F., Håkanson, R.: Immunohistochemical localization of human pancreatic polypeptide (HPP) to a population of islet cells. Cell Tiss. Res. 156, 167–171 (1975)
Larsson, L.-I., Sundler, F., Håkanson, R.: Pancreatic polypeptide — A postulated new hormone: Identification of its cellular storage site by light and electron microscopic immunocytochemistry. Diabetologia 12, 211–226 (1976b)
Larsson, L.-I., Sundler, F., Håkanson, R., Pollock, H.G., Kimmel, J.R.: Localization of APP, a postulated new hormone, to a pancreatic endocrine cell type. Histochem. 42, 377–382 (1974)
Lin, T.M., Chance, R.E.: Gastrointestinal actions of a new bovine pancreatic polypeptide (BPP). In: Endocrinology of the gut. Edit. by Chey and Brooks, pp. 143–145. New Jersey: C.B. Slack Inc. 1974
Pictet, R., Rutter, W.J.: Development of the embryonic endocrine pancreas. In: Handbook of physiology, Section: Endocrinology. Vol. 1, Endocrine pancreas. Eds. D.F. Stiner and N. Freinkel, 1972, pp. 25–66
Rufener, C, Baetens, D., Orci, L.: Localization of bovine pancreatic polypeptide (BPP)-like immunoreactivity in rat pancreatic monolayer culture. Experientia (Basel) 32, 919–920 (1976)
Schwartz, T.W., Rehfeld, J.F., Stadil, F., Larsson, L.-I., Chance, R.E., Moon, N.: Pancreaticpolypeptide response to food in duodenal-ulcer patients before and after vagotomy. Lancet 1976 I, 1102–1105
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sundler, F., Håkanson, R. & Larsson, LI. Ontogeny of rat pancreatic polypeptide (PP) cells. Cell Tissue Res. 178, 303–306 (1977). https://doi.org/10.1007/BF00218694
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00218694