Abstract
This is a study conducted on thirty adult strabismic and anisometropic amblyopes using colour vision tests, the lightness discrimination test, mesopic vision and visual evoked responses, in order to determine the probable site of the amblyopic defect. The results showed that, in its progressed stages, amblyopia is associated with eccentric fixation, abnormal hue discrimination, disturbed lightness discrimination and mesopic vision, and attenuation of the amplitude of the pattern visual evoked response. It is suggested that these abnormalities result from a defect involving the extrastriate higher visual association areas 18 & 19 of Brodmann.
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References
Arden GB and Barnard WM (1979) Effect of occlusion on the visual evoked response in amblyopia. Trans Ophthal Soc UK 99:419–426
Arden GB, Barnard WM and Mushin AS (1974) Visually evoked responses in amblyopia. Brit J Ophthal 58:183–192
Arden GB and Gukukoglu AG (1978) Grating test of contrast sensitivity in patients with retrobulbar neuritis. Arch Ophthal 96:1626–1629
Bishop PO (1975) Binocular vision. In: Moses, RA (ed) Adler's Physiology of the eye, 6th ed. St. Louis, Mosby
Burian HM (1956) Thoughts on the nature of amblyopia ex anopsia. Am Orthopt J 6:5
Burian HM (1967) The behaviour of the amblyopic eye under reduced illumination and the theory of functional amblyopia. Doc Ophthal 23:189–202
Cleland BG, Dubin MW and Levick WR (1971) Sustained and transient neurones in the cat's retina and lateral geniculate nucleus. J Physiol (London) 217:473–496
Damasio A, Yamada T, Damasio H, Corbett J and McKee J (1980) Central achromatopsia: Behavioural, anatomic, and physiologic aspects. Neurology 30:1064–1071
Dawson WW, Perry NW and Childers DG (1972) Variation in human cortical response to patterns and image quality. Invest Ophthal 11:789–799
Dodt E (1956) Centrifugal impulses in rabbits' retina. J Neurophysiol 19:301
Franceschetti AT and Burian HM (1971) Visually evoked responses in alternating strabismus. Amer J Ophthal 71:1292–1297
Gilchrist AL (1977) Perceived lightness depends on perceived spatial arrangement. Science 195:185–187
Granit R (1955) Centrifugal and antidromic effects on ganglion cells of retina. J Neurophysiol 18:388–411
Hess RF (1977) On the relationship between strabismic amblyopia and eccentric fixation. Brit J Ophthal 61:767–773
Hess RF, Bradley A and Piotrowski L (1983) Contrast-coding in amblyopia. I. Difference in the neural basis of human amblyopia. Proc R Soc London, B 217:309–330
Hess RF and Plant GT (1983) The effect of temporal frequency variation on threshold contrast sensitivity deficits in optic neuritis. J Neurol Neurosurg Psychiatry 46:322–330
Hoffmann KP, Stone J and Sherman SM (1972) Relay of receptive field properties in dorsal lateral geniculate nucleus of the cat. J Neuro Physiol 35:518–531
Hubel DH and Wiesel TN (1968) Receptive fields and functional architecture of monkey striate cortex. J Physiol 195:215–243
Hubel DH and Wiesel TN (1970) Cells sensitive to binocular depth in area 18 of the macaque monkey cortex. Nature 225:41–42
Ikeda H and Tremain KE (1980) Amblyopia and cortical binocularity. Trans Ophthal Soc UK 100:450–452
Jeffreys DA (1971) Cortical source location of the pattern-related visual evoked potentials recorded from the human scalp. Nature 229:502–504
Kulikowski JJ and Tolhurst DJ (1973) Psychophysical evidence for sustained and transient detectors in human vision. J Physiol (London) 232:149–162
Meadows JC (1974) Disturbed perception of colours associated with localised cerebral lesions. Brain 97:615–632
Millodot M (1966) Foveal and extrafoveal acuity with and without stabilised retinal images. Brit J Physiol Opt 23:75–106
Noorden GK von (1978) Amblyopia, basic concepts and current treatment. In: Symposium on Strabismus. Transactions of the New Orleans Academy of Ophthalmology. St. Louis, Mosby
Pearlman AL, Birch J and Meadows JC (1979) Cerebral colour blindness:an acquired defect in hue discrimination. Ann Neurol 5:253–261
Pinckers A (1984) Clinical colour vision examination. Docum Ophthal Proc Ser 39:171–179
Pinckers A and Marré M (1983) Basic phenomena in acquired colour vision deficiency. Docum Ophthal 55:251–271
Pinckers A and Verriest G (1985) Le New Color Test de Lanthony. V. Classement des gris. J Fr Ophtal 8:263–265
Ruddock KH and Waterfield VA (1978) Central representation of colour vision deduced from studies on a subject with a central colour vision defect. Mod Probl Ophthal 19: 336–340
Safran AB, Felgenhauer WR and Roth A (1984) Transient cerebral achromatopsia. In: Varriest G (ed), Colour Vision Deficiencies VII. The Hague, Dr W. Junk, Publishers, pp. 419–423
Schmielau F and Singer W (1977) The role of visual cortex for binocular interactions in the cat lateral geniculate nucleus. Brain Res 120:354–361
Schor CM and Westall C (1984) Visual and vestibular sources of fixation instability in amblyopia. Invest Ophthal Vis Sci 25:729–738
Simons K and Reinecke RD (1978) Amblyopia screening and stereopsis. In: Symposium on Strabismus, Transactions of the New Orleans Academy of Ophthalmology. St. Louis, Mosby
Sokol S (1976) Visually evoked potentials: Theory, techniques and clinical applications. Survey Ophthal 21:18–44
Sokol S (1983) Abnormal evoked potential latencies in amblyopia. Brit J Ophthal 67: 310–314
Srebro R (1984) Visually evoked potentials in eccentrically and centrally fixing amblyopes. Brit J Ophthal 68:468–471
Tolhurst DJ (1973) Separate channels for the analysis of the shape and movement of a moving visual stimulus. J Physiol (London) 230:385–402
Uttal W and Matheson G (1971) Contour enhancement and simultaneous contrast: Are they mediated by the same neural mechanism? Paper presented at Psychon. Soc. Meetings, St. Louis, MO. Cited by Gibbs and Lawson (1974) Vision Res 14:983–986
Van Balen A Th M and Henkes HE (1962) Attention and amblyopia: Electroencephalographic approach to an ophthalmological problem. Brit J Ophthal 46:12–20
Verriest G, Uvijls A, Aspinall P and Hill A (1979) The lightness discrimination test. Bull Soc Belge Ophtal 183:162–180
Vola JJ, Riss M, Jayle GE, Gosset A and Tassy A (1972) Acquired deficiency of colour vision in lateral homonymous hemianopia. Mod Probl Ophthal 11:150–159
Wanger P and Nilsson BY (1978) Visual evoked responses to pattern-reversal stimulation in patients with amblyopia and/or defective binocular functions. Acta Ophthal 56: 617–627
Wanger P and Persson HE (1980) Visual evoked responses to pattern-reversal stimulation in childhood amblyopia. Acta Ophthal 58:697–706
Wolkstein M, Atkin A and Bodis-Wollner I (1980) Contrast sensitivity in retinal disease. Ophthalmology 87:1140–1149
Wooten BR (1982) Partial cerebral achromatopsia with selective hue loss. Docum Ophthal Proc Ser 33:139–144
Zeki SM (1980) The representation of colours in the cerebral cortex. Nature 284:412–418
Zeki SM (1983) The distribution of wavelength and orientation selective cells in different areas of the monkey visual cortex. Proc R Soc London B 217:449–470
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Mtanda, A.T., Cruysberg, J.R.M., Pinckers, A. et al. Evaluation of colour vision, mesopic vision, visual evoked potentials and lightness discrimination in adult amblyopes. Doc Ophthalmol 62, 247–264 (1986). https://doi.org/10.1007/BF00212650
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DOI: https://doi.org/10.1007/BF00212650