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Peripheral Tγ lymphocyte population in head and neck cancer

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Summary

Peripheral Tγ lymphocytes were measured in head and neck cancer patients and controls. The percentage was significantly higher in the 59 cancer patients than in the 46 normal controls (P<0.001). The 12 patients with recurrent disease had elevated percentages of Tγ lymphocytes compared with the untreated group (n=31; P<0.05) and the treated, disease-free group (n=16; P<0.05). Moreover, the percentage of Tγ lymphocytes was significantly higher in the 31 patients with regional lymph node metastasis than in the node-negative group (n=28; P<0.05). In a total of 37 patients with squamous cell carcinoma histologically graded I, II, and III, the absolute counts and percentages of Tγ lymphocytes in the grade I group (n=13) showed significant decreases compared with those in the grade III group (P<0.05; n=6). Moreover, postoperative serial determinations of the percentage of Tγ lymphocytes in the 14 treated, disease-free patients revealed a gradual decrease of Tγ lymphocytes, whereas the five patients with recurrent disease had a tendency to increases in the percentage of Tγ lymphocytes.

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Authors and Affiliations

  1. Central Laboratory for Clinical Investigation, Tokushima University School of Dentistry, 3 Kuramoto-cho, 770, Tokushima, Japan

    Yoshio Hayashi & Toshinobu Nishida

  2. Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry, 3 Kuramoto-cho, 770, Tokushima, Japan

    Hideo Yoshida, Tetsuo Yanagawa, Yoshiaki Yura, Nanayo Furumoto & Mitsunobu Sato

Authors
  1. Yoshio Hayashi
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  2. Toshinobu Nishida
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  3. Hideo Yoshida
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  4. Tetsuo Yanagawa
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  5. Yoshiaki Yura
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  6. Nanayo Furumoto
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  7. Mitsunobu Sato
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Abbreviations used in this paper: SMF, sodium metrizoate-Ficoll; PBS, phosphate-buffered saline; SRBC, sheep erythrocytes; FCS, fetal calf serum; Hepes, hydroxyethylpiperazin elthene-sulfonic acid; E, erythrocyte; EAC, erythrocyte-antibody-complement; K, antibody-dependent killer; NK, natural killer

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Hayashi, Y., Nishida, T., Yoshida, H. et al. Peripheral Tγ lymphocyte population in head and neck cancer. Cancer Immunol Immunother 17, 160–164 (1984). https://doi.org/10.1007/BF00205480

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  • DOI: https://doi.org/10.1007/BF00205480

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