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Subthreshold argon-laser irradiation elicits a pronounced vitreal prostaglandin E2 response

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Abstract

Chorioretinal production of prostaglandin type E2 (PGE2) as well as changes in vitreal protein and PGE2 concentrations were studied following retinal irradiation with low-power laser energy that caused ophthalmoscopically invisible (“subthreshold”) laser burns. This was compared with changes following ophthalmoscopically visible (“ suprathreshold ”) laser burns. Our results demonstrate that with in eyes exposed to the lower-power levels, the enhancement in vitreal PGE2 concentration persisted for a longer period and was more pronounced than in eyes exposed to the suprathreshold levels (a 3-fold and a 2-fold increase above baseline values, respectively). Protein leakage into the vitreous was noted only in the suprathreshold group, indicating a blood-retinal barrier (BRB) disruption. The findings of persistent, excessive PGEZ vitreal levels with no protein leakage in the subthreshold group suggest a possible anti-inflammatory role for PGEZ following low-power laser exposure.

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Authors and Affiliations

  1. The Maurice and Gabriela Goldschleger Eye Institute and Tel Aviv University, Sackler Faculty of Medicine, The Chaim Sheba Medical Center, 52621, Tel Hashomer, Israel

    Nava Naveh, Elisha Bartov & Chana Weissman

Authors
  1. Nava Naveh
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  2. Elisha Bartov
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  3. Chana Weissman
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Additional information

This work was partially supported by United States Army Medical Research and Development Command contract 17-85-G-5013

Offprint requests to: N. Naveh

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Naveh, N., Bartov, E. & Weissman, C. Subthreshold argon-laser irradiation elicits a pronounced vitreal prostaglandin E2 response. Graefe's Arch Clin Exp Ophthalmol 229, 178–181 (1991). https://doi.org/10.1007/BF00170553

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  • DOI: https://doi.org/10.1007/BF00170553

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