Abstract
In this study in vitro predegradation at elevated temperatures, used to obtain an increased degradation rate, was investigated. The in vitro degradation was followed by mass loss, molecular weight loss and changes in thermal properties. Two biodegradable polymers, the homopolymer PLLA and a copolymer PLA96 (96% L4%D lactide), were hydrolytically degraded at 90°C in a phosphate buffered solution. Both polymers, PLLA and PLA96, showed an initial linear degradation rate, but with longer implantation periods the degradation rate decreased and total degradation was best described as an asymptotic. Mass loss of the copolymer PLA96 was twice that of PLLA. The chemical analysis of the in vitro predegraded polymers coincided for both the decrease in molecular weight and the thermal properties with physiologically degraded poly(lactide). The results of this study show that although the degradation temperature is well above the glass transition temperature and not comparable to physiological temperatures, there seems to be good correlation between the in vitro degraded material and physiologically degraded material. In vitro predegradation enables investigation of the entire degradation process of a polymer in a short-term study. Moreover, in vitro predegradation allows direct comparison of the degradation rate of various polymers.
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R. R. M. BOS, F. R. ROZEMA, G. BOERING, A. J. NIJENHUIS, A. J. PENNINGS and A. B. VERWEY, J. Oral Maxillofac. Surg. 45 (1987) 751.
O. BOSTMAN, E. A. MAKELA, P. TOMALA and P. ROKKANEN, J. Bone Jt. Surg. [Br] 17-B (1987) 706.
O. BOSTMAN, J. Bone Joint Surg. 73A (1991) 148.
H. MIETINNEN, E. A. MAKELA, P. ROKKANEN and P. TORMALA, J. Biomater. Sci. Polym. Ed. 4 (1992) 135.
E. K. PARTIO, J. MERIKANTO, J. T. HEIKILLA, P. YLINEN, E. A. MAKELA, J. VAINO, P. TORMALA and P. ROKKANEN, J. Pediatr. Orthop. 12 (1992) 646.
H. PIHLAJAMAKI, O. BOSTMAN, E. HIRVENSALO, P. TORMALA and P. ROKKANEN, J. Bone Joint Surg. [Br] 74 (1992) 853.
A. M. DONIGAN, B. R. PLAGA and P. M. CASKEY, J. Pediatr. Orthop. 13 (1993) 349.
P. CHRISTEL, M. VERT, F. CHABOT, H. GARREAU and M. AUDION, in “Composites in biomedical engineering”, Plastic and Rubber institute Proceedings (1985) 11/1-11/10R.
R. SUURONEN, P. L. LAINE, T. POHJONEN and C. LINDQVIST, J. Oral Maxillofac. Surg. 52 (1994) 715.
J. E. BERGSMA, W. C.DE BRUIJN, F. R. ROZEMA, R. R. M. BOS and G. BOERING, Biomaterials 16 (1995) 25.
J. E. BERGSMA, F. R. ROZEMA, R. R. M. BOS and W. C.DE BRUIJN, J. Oral Maxillofac. Surg. 51 (1993) 666.
F. R. ROZEMA, W. C. de BRUIJN, R. R. M. BOS, G. BOERING, A. J. NIJENHUIS and A. J. PENNINGS, “Biomaterial-tissue interfaces”, edited by P. J. Doherty, R. L. Williams, D. F. Williams, A. T. L. Lee, Advances in Biomaterials (Elsevier 10, 1992) p. 349.
R. SUURONEN, P. LAINE, E. SARKIALA, T. POHJONEN and C. LINDQVIST, Int. J. Oral Maxillifac. Surg. 21 (1992) 303.
O. BOSTMAN, U. PAIVARINTA, M. MANNINEN and P. ROKKANEN, Acta. Orthop. Scand. 6 (1992) 555.
F. R. ROZEMA, J. E. BERGSMA, R. R. M. BOS, G. BOERING, A. J. NIJENHUIS, A. J. PENNINGS and W. C.DE BRUIJN, J. Mater. Sci. Mater. Med. 5 (1994) 575.
J. E. BERGSMA, F. R. ROZEMA, R. R. M. BOS, D. W. GRIJPMA, G. BOERING and W. C.DE BRUIJN, Biomaterials 16 (1995) 267.
B. BUCHHOLZ, in “Degradation phenomena on polymeric biomaterials” (Springer-Verlag, Berlin, Heidelberg, 1992) p. 67.
J. W. LEENSLAG and A. J. PENNINGS, Macromol. Chem. 45 (1987) 751.
R. R. M. BOS, F. R. ROZEMA, G. BOERING, A. J. NIJENHUIS, A. J. PENNINGS, A. B. VERWEY, P. NIEUWENHUIS and H. W. B. JANSEN, Biomaterials 12 (1991) 32.
H. PISTNER, D. R. BENDIX, J. MUHLING and J. F. REUTHER, Biomaterials 14 (1993) 291.
X. ZHANG, U. P. WYSS, D. PICHORA and M. F. A. GOOSEN, J. Bioact. Compat. Polym. 9 (1994) 80.
S. LI, H. GARREAU and M. VERT, J. Mater. Sci. Mater. Med. 1 (1990) 198.
S. LI, H. GARREAU and M. VERT, J. Mater. Sci. Mater. Med. 1 (1990) 123.
E. W. FISCHER, H. J. STERTZEL and G. WEGNER, Kolloid-Z. u. Z. Polymere 251 (1973) 980.
F. W. CORDEWENER, F. R. ROZEMA, R. R. M. BOS and G. BOERING, J. Mater. Sci. Mater. Med. 6 (1995) 211.
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Bergsma, J.E., Rozema, F.R., Bos, R.R.M. et al. In vitro predegradation at elevated temperatures of poly(lactide). J Mater Sci: Mater Med 6, 642–646 (1995). https://doi.org/10.1007/BF00123445
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DOI: https://doi.org/10.1007/BF00123445