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Production of the antibiotic cyanobacterin LU-1 by Nostoc linckia CALU 892 (cyanobacterium)

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Abstract

Cyanobacterin LU-1, produced by Nostoc linckia CALU 892, inhibits the growth of many cyanobacteria and eukaryotic algae. The minimum effective dose of a crude preparation to Synechococcus sp. R-2 is ca 1 µg ml−1. The antibiotic hinders cell division and light-dependent oxygen evolution in Synechococcus sp. R-2 (PCC 7942) cells. It is not active against heterotrophic bacteria and fungi, and is non-toxic to mice.

Purified cyanobacterin LU-1 contains a nitrous heterocycle with sugar and phenolic substituents. Cyanobacterin LU-1 accumulates in the medium during the course of growth, although not in direct proportion to cell density. Productivity of the culture depends on temperature.

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Authors and Affiliations

  1. Biological Institute of Leningrad University, Oraniyenbaumskoye Sch. 2, Stariy Peterhof, Leningrad, 198904, USSR

    Boris V. Gromov, Alexey A. Vepritskiy, Nina N. Titova, Kira A. Mamkayeva & Olga V. Alexandrova

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  1. Boris V. Gromov
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  2. Alexey A. Vepritskiy
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  3. Nina N. Titova
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  4. Kira A. Mamkayeva
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  5. Olga V. Alexandrova
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Gromov, B.V., Vepritskiy, A.A., Titova, N.N. et al. Production of the antibiotic cyanobacterin LU-1 by Nostoc linckia CALU 892 (cyanobacterium). J Appl Phycol 3, 55–59 (1991). https://doi.org/10.1007/BF00003919

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  • DOI: https://doi.org/10.1007/BF00003919

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