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Pathologic and Molecular Characteristics

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Gastrointestinal Cancer

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Abstract

Gastric cancer develops from the lining of the stomach. In particular, gastric adenocarcinoma is a malignant epithelial tumor of the gastric mucosa. The intratumoral and intertumoral heterogeneity of gastric cancer are a challenge to overcome to better understand its underlying pathophysiology.

An Na Seo is the lead author of this chapter.

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References

  1. Japanese Gastric Cancer A. Japanese gastric cancer treatment guidelines 2018 (5th edition). Gastric Cancer 2021;24:1–21.

    Google Scholar 

  2. Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand. 1965;64:31–49.

    Article  CAS  PubMed  Google Scholar 

  3. Voron T, Messager M, Duhamel A, Lefevre J, Mabrut JY, Goere D, et al. Is signet-ring cell carcinoma a specific entity among gastric cancers? Gastric Cancer. 2016;19:1027–40.

    Article  CAS  PubMed  Google Scholar 

  4. Mariette C, Carneiro F, Grabsch HI, van der Post RS, Allum W, de Manzoni G. Consensus on the pathological definition and classification of poorly cohesive gastric carcinoma. Gastric Cancer. 2019;22:1–9.

    Article  CAS  PubMed  Google Scholar 

  5. Kunisaki C, Akiyama H, Nomura M, Matsuda G, Otsuka Y, Ono HA, et al. Clinicopathologic characteristics and surgical outcomes of mucinous gastric carcinoma. Ann Surg Oncol. 2006;13:836–42.

    Article  PubMed  Google Scholar 

  6. Hyung WJ, Noh SH, Shin DW, Yoo CH, Kim CB, Min JS, et al. Clinicopathologic characteristics of mucinous gastric adenocarcinoma. Yonsei Med J. 1999;40:99–106.

    Article  CAS  PubMed  Google Scholar 

  7. Lee HS, Kim WH, Kwak Y, Koh J, Bae JM, Kim K-M, et al. Molecular testing for gastrointestinal Cancer. J Pathol Transl Med. 2017;51:103–21.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Hissong E, Ramrattan G, Zhang P, Zhou XK, Young G, Klimstra DS, et al. Gastric carcinomas with lymphoid stroma: an evaluation of the histopathologic and molecular features. Am J Surg Pathol. 2018;42:453–62.

    Article  PubMed  Google Scholar 

  9. Eom DW, Kang GH, Han SH, Cheon GJ, Han KH, Oh HS, et al. Gastric micropapillary carcinoma: a distinct subtype with a significantly worse prognosis in TNM stages I and II. Am J Surg Pathol. 2011;35:84–91.

    Article  PubMed  Google Scholar 

  10. Li C, Wu X, Yang S, Yang X, Yao J, Zheng H. Gastric adenocarcinoma of the fundic gland type: clinicopathological features of eight patients treated with endoscopic submucosal dissection. Diagn Pathol. 2020;15:131.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Ueyama H, Matsumoto K, Nagahara A, Hayashi T, Yao T, Watanabe S. Gastric adenocarcinoma of the fundic gland type (chief cell predominant type). Endoscopy. 2014;46:153–7.

    PubMed  Google Scholar 

  12. Benedict MA, Lauwers GY, Jain D. Gastric adenocarcinoma of the fundic gland type: update and literature review. Am J Clin Pathol. 2018;149:461–73.

    Article  PubMed  Google Scholar 

  13. Chia NY, Tan P. Molecular classification of gastric cancer. Ann Oncol. 2016;27:763–9.

    Article  PubMed  Google Scholar 

  14. Lei Z, Tan IB, Das K, Deng N, Zouridis H, Pattison S, et al. Identification of molecular subtypes of gastric cancer with different responses to PI3-kinase inhibitors and 5-fluorouracil. Gastroenterology. 2013;145:554–65.

    Article  CAS  PubMed  Google Scholar 

  15. Network CGAR. Comprehensive molecular characterization of gastric adenocarcinoma. Nature. 2014;513:202–9.

    Article  Google Scholar 

  16. Cristescu R, Lee J, Nebozhyn M, Kim KM, Ting JC, Wong SS, et al. Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes. Nat Med. 2015;21:449–56.

    Article  CAS  PubMed  Google Scholar 

  17. Oh SC, Sohn BH, Cheong JH, Kim SB, Lee JE, Park KC, et al. Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype. Nat Commun. 2018;9:1777.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Setia N, Agoston AT, Han HS, Mullen JT, Duda DG, Clark JW, et al. A protein and mRNA expression-based classification of gastric cancer. Mod Pathol. 2016;29:772–84.

    Article  CAS  PubMed  Google Scholar 

  19. Sohn BH, Hwang JE, Jang HJ, Lee HS, Oh SC, Shim JJ, et al. Clinical significance of four molecular subtypes of gastric cancer identified by the cancer genome atlas project. Clin Cancer Res. 2017;23:4441–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Ahn S, Lee SJ, Kim Y, Kim A, Shin N, Choi KU, et al. High-throughput protein and mRNA expression-based classification of gastric cancers can identify clinically distinct subtypes, concordant with recent molecular classifications. Am J Surg Pathol. 2017;41:106–15.

    Article  PubMed  Google Scholar 

  21. Bang YJ, Van Cutsem E, Feyereislova A, Chung HC, Shen L, Sawaki A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet. 2010;376:687–97.

    Article  CAS  PubMed  Google Scholar 

  22. Bartley AN, Washington MK, Colasacco C, Ventura CB, Ismaila N, Benson AB 3rd, et al. HER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma: Guideline From the College of American Pathologists, American Society for Clinical Pathology, and the American Society of Clinical Oncology. J Clin Oncol. 2017;35:446–64.

    Article  CAS  PubMed  Google Scholar 

  23. Hofmann M, Stoss O, Shi D, Büttner R, van de Vijver M, Kim W, et al. Assessment of a HER2 scoring system for gastric cancer: results from a validation study. Histopathology. 2008;52:797–805.

    Article  CAS  PubMed  Google Scholar 

  24. Kim KM, Bilous M, Chu KM, Kim BS, Kim WH, Park YS, et al. Human epidermal growth factor receptor 2 testing in gastric cancer: recommendations of an Asia-Pacific task force. Asia Pac J Clin Oncol. 2014;10:297–307.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Rüschoff J, Hanna W, Bilous M, Hofmann M, Osamura RY, Penault-Llorca F, et al. HER2 testing in gastric cancer: a practical approach. Mod Pathol. 2012;25:637–50.

    Article  PubMed  Google Scholar 

  26. Park SR, Park YS, Ryu MH, Ryoo BY, Woo CG, Jung HY, et al. Extra-gain of HER2-positive cases through HER2 reassessment in primary and metastatic sites in advanced gastric cancer with initially HER2-negative primary tumours: results of GASTric cancer HER2 reassessment study 1 (GASTHER1). Eur J Cancer. 2016;53:42–50.

    Article  CAS  PubMed  Google Scholar 

  27. Kaito A, Kuwata T, Tokunaga M, Shitara K, Sato R, Akimoto T, et al. HER2 heterogeneity is a poor prognosticator for HER2-positive gastric cancer. World J Clin Cases. 2019;7:1964–77.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Haffner I, Schierle K, Raimúndez E, Geier B, Maier D, Hasenauer J, et al. HER2 expression, test deviations, and their impact on survival in metastatic gastric Cancer: results from the prospective multicenter VARIANZ study. J Clin Oncol. 2021;39:1468–78.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Gulley ML. Molecular diagnosis of Epstein-Barr virus-related diseases. J Mol Diagn. 2001;3:1–10.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Ambinder RF, Mann RB. Epstein-Barr-encoded RNA in situ hybridization: diagnostic applications. Hum Pathol. 1994;25:602–5.

    Article  CAS  PubMed  Google Scholar 

  31. Topalian SL, Taube JM, Anders RA, Pardoll DM. Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy. Nat Rev Cancer. 2016;16:275–87.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Kwak Y, Seo AN, Lee HE, Lee HS. Tumor immune response and immunotherapy in gastric cancer. J Pathol Transl Med. 2020;54:20–33.

    Article  PubMed  Google Scholar 

  33. Kawazoe A, Kuwata T, Kuboki Y, Shitara K, Nagatsuma AK, Aizawa M, et al. Clinicopathological features of programmed death ligand 1 expression with tumor-infiltrating lymphocyte, mismatch repair, and Epstein-Barr virus status in a large cohort of gastric cancer patients. Gastric Cancer. 2017;20:407–15.

    Article  CAS  PubMed  Google Scholar 

  34. Kim ST, Cristescu R, Bass AJ, Kim KM, Odegaard JI, Kim K, et al. Comprehensive molecular characterization of clinical responses to PD-1 inhibition in metastatic gastric cancer. Nat Med. 2018;24:1449–58.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Internal Medicine, Korea University Anam Hospital, Seoul, Korea (Republic of)

    Hoon Jai Chun

  2. Department of Internal Medicine, Kosin University Gospel Hospital, Busan, Korea (Republic of)

    Seun Ja Park

  3. Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, Kyonggi-do, Korea (Republic of)

    Yun Jeong Lim

  4. Department of Internal Medicine, Yonsei University Severance Hospital, Seoul, Korea (Republic of)

    Si Young Song

Authors
  1. Hoon Jai Chun
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  2. Seun Ja Park
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  3. Yun Jeong Lim
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  4. Si Young Song
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© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

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Chun, H.J., Park, S.J., Lim, Y.J., Song, S.Y. (2023). Pathologic and Molecular Characteristics. In: Gastrointestinal Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-99-0815-8_3

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  • DOI: https://doi.org/10.1007/978-981-99-0815-8_3

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-99-0814-1

  • Online ISBN: 978-981-99-0815-8

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