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Exploring the Potential of Medicinal Plants in Lung Cancer

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Medicinal Plants for Lung Diseases

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Abstract

Lung carcinoma is the main cause of death among individuals, accounting for almost 25% of all deaths from cancer. A significant number of individual’s perish due to lung cancer per year as compared to the colon, prostate, and breast cancer problem. Smoking and the use of tobacco products have been found to be responsible for nearly 90% of lung cancer cases. However, other factors may lead to lung carcinogenesis, such as air pollution exposures, asbestos, radon gas, and other chronic infections. The most used techniques for the treatment of lung carcinoma are chemotherapy, radiotherapy, and surgery. Standard chemotherapies, however, present severe patient toxicity, side effects and can result in minimal survival benefits. There are many medicinal plants having potential against lung cancer with minimal or no side effects, and, therefore, can be explored scientifically. These plant-derived phytochemicals and antitumor herbs have attracted the investigators/scientists due to their least or no harmful effects to the patient under treatment, as in case of chemotherapy. Studies have reported the covering of different approaches for treatment of lung cancer, however, a cumulative study comprising of the alternative options with natural compounds for lung cancer treatment is in the initial stages and the natural lead molecules responsible for the treatment using herbal medicinal plants are still very scarce. In the present chapter, epidemiology of lung cancer, lung cancer types, its underlying causes, and herbal medicines along with their lead compounds for the treatment of lung carcinoma have been discussed.

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Abbreviations

BAC:

Bronchioloalveolar carcinoma

DDP:

Diamminedichloroplatinum

EGFR:

Endothelial growth factor receptor

HIF:

Hypoxia inducing factor

LCNEC:

Large cell neuroendocrine carcinoma

nAChR:

Nicotinicacetylcholine receptor

NSCLC:

Non-small cell lung cancer

PARP:

Poly-ADP ribose polymerase

SCLC:

Small cell lung cancer

SM:

Solamargine

SNP:

Single nucleotide polymorphism

TNF:

Tumor necrosis factor

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India

    Anju Dhiman & Harish Dureja

Authors
  1. Anju Dhiman
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  2. Harish Dureja
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Correspondence to Harish Dureja .

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Editors and Affiliations

  1. Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW, Australia

    Kamal Dua

  2. Discipline of Medical Sciences, School of Science, Western Sydney University, Sydney, NSW, Australia

    Srinivas Nammi

  3. NICM Health Research Institute, Western Sydney University, Sydney, NSW, Australia

    Dennis Chang

  4. Department of Life Sciences, School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia

    Dinesh Kumar Chellappan

  5. School of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajasthan, India

    Gaurav Gupta

  6. Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia

    Trudi Collet

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Dhiman, A., Dureja, H. (2021). Exploring the Potential of Medicinal Plants in Lung Cancer. In: Dua, K., Nammi, S., Chang, D., Chellappan, D.K., Gupta, G., Collet, T. (eds) Medicinal Plants for Lung Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-33-6850-7_11

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