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Frontiers in Psychiatry pp 95–115Cite as

Neuroimaging of Small Vessel Disease in Late-Life Depression

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1192))

Abstract

Cerebral small vessel disease is associated with late-life depression, cognitive impairment, executive dysfunction, distress, and loss of life for older adults. Late-life depression is becoming a substantial public health burden, and a considerable number of older adults presenting to primary care have significant clinical depression. Even though white matter hyperintensities are linked with small vessel disease, white matter hyperintensities are nonspecific to small vessel disease and can co-occur with other brain diseases. Advanced neuroimaging techniques at the ultrahigh field magnetic resonance imaging are enabling improved characterization, identification of cerebral small vessel disease and are elucidating some of the mechanisms that associate small vessel disease with late-life depression.

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Authors and Affiliations

  1. Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA

    Nadim S. Farhat, Tales Santini, Tamer S. Ibrahim & Howard J. Aizenstein

  2. School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA

    Robert Theiss

  3. Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA

    Tamer S. Ibrahim & Howard J. Aizenstein

  4. Department of Radiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA

    Tamer S. Ibrahim

  5. Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA, USA

    Howard J. Aizenstein

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    Yong-Ku Kim

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Farhat, N.S., Theiss, R., Santini, T., Ibrahim, T.S., Aizenstein, H.J. (2019). Neuroimaging of Small Vessel Disease in Late-Life Depression. In: Kim, YK. (eds) Frontiers in Psychiatry. Advances in Experimental Medicine and Biology, vol 1192. Springer, Singapore. https://doi.org/10.1007/978-981-32-9721-0_5

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