Abstract
Alginate obtained from brown seaweeds has numerous biomedical applications. It is an excellent excipient in drug delivery systems, serving as a stability agent in different types of pharmaceutical formulations. Alginates have significant applications in nanomedicines, such as dendrimers, nanocrystals, emulsions, liposomes, solid lipid nanoparticles, micelles, and polymeric nanoparticles, and have more advantages in comparison to conventional medications in terms of efficacy, safety, pharmacokinetic/pharmacodynamic property, and physicochemical properties. Polymer-based drug delivery approaches have gained lot of interest in past decade. Newer techniques and innovations have given us opportunity to utilize natural biopolymers for various life-threatening diseases. Respiratory diseases being one of the leading causes of death in recent years which include asthma, chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, pneumonia, and lung cancer that results in decline in lung function. Recent advances in nanotechnology have shed new light on the current treatment of chronic airway disease. This chapter is focused on the management of respiratory disease with more emphasis on the recent advances in nanotechnology-based therapeutics utilizing alginate polymers.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Ahmad Z, Sharma S, Khuller GK (2007) Chemotherapeutic evaluation of alginate nanoparticle-encapsulated azole antifungal and antitubercular drugs against murine tuberculosis. Nanomedicine 3:239–243
Andrade F, Rafael D, Videira M, Ferreira D, Sosnik A, Sarmento B (2013) Nanotechnology and pulmonary delivery to overcome resistance in infectious diseases. Adv Drug Deliv Rev 65(13–14):1816–1827
Bedi RS (2006) Community acquired Pneumonia-typical or atypical? Lung India 23(3):130–131
Behera D (2010) Text book of pulmonary medicine. Indian J Chest Dis Allied Sci 52:173
Bullington W, Smyth A, Elborn S, Drevinek P, Hempstead S, Muhlebach M (2019) 1078. Expectations and attitudes toward antimicrobial stewardship among cystic fibrosis care providers. In: Open forum infectious diseases, vol. 6
Camporese A (2012) Impact of recent advances in molecular techniques on diagnosing lower respiratory tract infections (LRTIs). Le Infezioni Med 20(4):237–244
Ching SH, Bansal N, Bhandari B (2017) Alginate gel particles-a review of production techniques and physical properties. Crit Rev Food Sci Nutr 57(6):1133–1152
Christiansen K (1996) Treatment of common lower respiratory tract infections. NPS Med Wise:48–51
Clark DE, Green HC. Alginic acid and process of making same. 2036922 US Patent. 1936
Colinet I, Dulong V, Hamaide T, Le Cerf D, Picton L (2009) New amphiphilic modified polysaccharides with original solution behaviour in salt media. Carbohydr Polym 75:454–462
Creary M, Williamson D, Kulkarni R (2007) Sickle cell disease: current activities, public health implications, and future directions. J Women's Health 16(5):575–582
Denholm R, Van der Werf ET, Hay AD (2020) Use of antibiotics and asthma medication for acute lower respiratory tract infections in people with and without asthma: retrospective cohort study. Respir Res 21(1):1–2
Dhoot NO, Tobias CA, Fischer I, Wheatley MA (2004) Peptide-modified alginate surfaces as a growth permissive substrate for neurite outgrowth. J Biomed Mater Res Part A 71:191–200
Du A, Zheng R, Disoma C, Li S, Chen Z, Li S, Liu P, Zhou Y, Shen Y, Liu S, Zhang Y (2021) Epigallocatechin-3-gallate, an active ingredient of Traditional Chinese Medicines, inhibits the 3CLpro activity of SARS-CoV-2. Int J Biol Macromol 176:1–2
Duncker HR (2004) Vertebrate lungs: structure, topography and mechanics: a comparative perspective of the progressive integration of respiratory system, locomotor apparatus and ontogenetic development. Respir Physiol Neurobiol 144(2-3):111–124
Fedde MR (1980) Structure and gas-flow pattern in the avian respiratory system. Poultry Sci 59(12):2642–2653
Feldman C, Richards G (2018) Appropriate antibiotic management of bacterial lower respiratory tract infections. F1000Res:7
George M, Abraham TE (2006) Polyionic hydrocolloids for the intestinal delivery of protein drugs. J Controlled Rel 114:1–14
Gulliford MC, Moore MV, Little P, Hay AD, Fox R, Prevost AT, Juszczyk D, Charlton J, Ashworth M (2016) Safety of reduced antibiotic prescribing for self-limiting respiratory tract infections in primary care: cohort study using electronic health records. BMJ 354
Hay ID, Rehman ZU, Ghafoor A, Rehm BHA (2010) Bacterial biosynthesis of alginates. J Chem Technol Biotechnol 85:752–759
Hsiong SX, Boontheekul T, Huebsch N, Mooney DJ (2009) Cyclic arginine-glycine-aspartate peptides enhance three-dimensional stem cell osteogenic differentiation. Tissue Eng Part A 15:263–272
Jain D, Bar-Shalom D (2014) Alginate drug delivery systems: application in context of pharmaceutical and biomedical research. Drug Dev Ind Pharm 40(12):1576–1584
Jana S, Kumar Sen K, Gandhi A (2016) Alginate based nanocarriers for drug delivery applications. Curr Pharmaceutical Des 22(22):3399–3410
Jarju S, Greenhalgh K, Wathuo M, Banda M, Camara B, Mendy S, Sowe G, Dahaba PO, Jammeh L, Bajinka Y, Sanneh P (2020) Viral etiology, clinical features and antibiotic use in children< 5 years of age in The Gambia presenting with influenza-like illness. Pediatr Infect Dis J 39(10):925–930
Jones JH, Effmann EL, Schmidt-Nielsen K (1985) Lung volume changes during respiration in ducks. Respir Physiol 59(1):15–25
Kathiravan MK, Salake AB, Chothe AS, Dudhe PB, Watode RP, Mukta MS, Gadhwe S (2012) The biology and chemistry of antifungal agents: a review. Bioorg Med Chem 20(19):5678–5698
King AS 1979. Systema respiratorium. In: Baumel JJ, King AS, Lucas AM, Breazile JE, Evans HE (eds) Nomina Anatomica Avium. pp 227–265
Kocsis B, Szabo D (2017) New treatment options for lower respiratory tract infections. Expert Opin Pharmacother 18(13):1345–1355
Kollef MH, Betthauser KD (2019) New antibiotics for community-acquired pneumonia. Curr Opin Infect Dis 32(2):169–175
Koo LY, Irvine DJ, Mayes AM, Lauffenburger DA, Griffith LG (2002) Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus. J Cell Sci 115:1423–1433
Kraus EM, Pelzl S, Szecsenyi J, Laux G (2017) Antibiotic prescribing for acute lower respiratory tract infections (LRTI)–guideline adherence in the German primary care setting: an analysis of routine data. PLoS One 12(3):e0174584
Lee KY, Mooney DJ (2012) Alginate: properties and biomedical applications. Prog Polym Sci 37(1):106–126
Lee KY, Kong HJ, Mooney DJ (2008) Quantifying interactions between cell receptors and adhesion ligand-modified polymers in solution. Macromol Biosci 8:140–145
Lehenkari PP, Horton MA (1999) Single integrin molecule adhesion forces in intact cells measured by atomic force microscopy. Biochem Biophys Res Commun 259:645–650
Leonard M, De Boisseson AR, Hubert P, Dalencon F, Dellacherie E (2004) Hydrophobically modified alginate hydrogels as protein carriers with specific controlled release properties. J Controlled Rel 98:395–405
Low D (2008) Reducing antibiotic use in influenza: challenges and rewards. Clin Microbiol Infect 14(4):298–306
Mahashur A (2018) Management of lower respiratory tract infection in outpatient settings: focus on clarithromycin. Lung India 35(2):143
Maina JN (1982) A stereological analysis of the paleopulmo and the neopulmo respiratory regions of the avian lung (streptopelia-decaocto). IRCS Med Sci-Biochem 10(4):328
Maina JN (2003a) A systematic study of the development of the airway (bronchial) system of the avian lung from days 3 to 26 of embryogenesis: a transmission electron microscopic study on the domestic fowl, Gallus gallus variant domesticus. Tissue Cell 35(5):375–391
Maina JN (2003b) Developmental dynamics of the bronchial (airway) and air sac systems of the avian respiratory system from day 3 to day 26 of life: a scanning electron microscopic study of the domestic fowl, Gallus gallus variant domesticus. Anat Embryol 207(2):119–134
Maina JN (2008) Functional morphology of the avian respiratory system, the lung–air sac system: efficiency built on complexity. Ostrich-J Afr Ornithol 79(2):117–132
Naghavi M, Abajobir AA, Abbafati C, Abbas KM, Abd-Allah F, Abera SF, Aboyans V, Adetokunboh O, Afshin A, Agrawal A, Ahmadi A (2017) Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet 390(10100):1151–1210
Pandey R, Ahmad Z, Sharma S, Khuller GK (2005) Nano-encapsulation of azole antifungals: potential applications to improve oral drug delivery. Int J Pharma 301(1–2):268–276
Patel SK, Shah DR, Tiwari S (2015) Bioadhesive films containing fluconazole for mucocutaneous candidiasis. Indian J Pharm Sci 77(1):55
Pelletier S, Hubert P, Payan E, Marchal P, Choplin L, Dellacherie E (2001) Amphiphilic derivatives of sodium alginate and hyaluronate for cartilage repair: rheological properties. J Biomed Mater Res 54:102–108
Pfaller MA, Mendes RE, Castanheira M, Flamm RK, Jones RN, Sader HS (2017) Ceftaroline activity tested against bacterial isolates causing community-acquired respiratory tract infections and skin and skin structure infections in pediatric patients from United States hospitals: 2012–2014. Pediatr Infect Dis J 36(5):486–491
Qin Y (2008) Alginate fibers: an overview of the production processes and applications in wound management. Polym Int 57:171–180
Remminghorst U, Rehm BHA (2006) Bacterial alginates: from biosynthesis to applications. Biotechnol Lett 28:1701–1712
Richter J, Panayiotou C, Tryfonos C, Koptides D, Koliou M, Kalogirou N, Georgiou E, Christodoulou C (2016) Aetiology of acute respiratory tract infections in hospitalised children in Cyprus. PLoS One 11(1):e0147041
Rinaudo M (2008) Main properties and current applications of some polysaccharides as biomaterials. Polym Int 57:397–430
Roco MC (2003) Nanotechnology: convergence with modern biology and medicine. Curr Opin Biotechnol 14(3):337–346
Rowbotham NJ, Smith S, Leighton PA, Rayner OC, Gathercole K, Elliott ZC, Nash EF, Daniels T, Duff AJ, Collins S, Chandran S (2018) The top 10 research priorities in cystic fibrosis developed by a partnership between people with CF and healthcare providers. Thorax 73(4):388–390
Ruopp M, Chiswell K, Thaden JT, Merchant K, Tsalik EL (2015) Respiratory tract infection clinical trials from 2007 to 2012. A systematic review of Clinical Trials. gov. Ann Am Thorac Soc 12(12):1852–1863
Ruuskanen O, Lahti E, Jennings LC, Murdoch DR (2011) Viral pneumonia. Lancet 377(9773):1264–1275
Sabuj MZ, Islam N (2021) Inhaled antibiotic-loaded polymeric nanoparticles for the management of lower respiratory tract infections. Nanoscale Adv 3(14):4005–4018
Sangeetha S, Venkatesh DN, Adhiyaman R, Santhi K, Suresh B (2007) Formulation of sodium alginate nano spheres containing amphotericin B for the treatment of systemic candidiasis. Trop J Pharm Res 6:653–659
Smidsrod O, Skjak-Bræk G (1990) Alginate as immobilization matrix for cells. Trend Biotechnol 8:71–78
Sosnik A (2014) Alginate particles as platform for drug delivery by the oral route: state-of-the-art. ISRN Pharmaceutics 2014. Article ID 926157, 17 pages
Stanojevic S, McDonald A, Waters V, MacDonald S, Horton E, Tullis E, Ratjen F (2017) Effect of pulmonary exacerbations treated with oral antibiotics on clinical outcomes in cystic fibrosis. Thorax 72(4):327–332
Suri SS, Fenniri H, Singh B (2007) Nanotechnology-based drug delivery systems. J Occup Med Toxicol 2(1):1–6
Szekalska M, Puciłowska A, Szymańska E, Ciosek P, Winnicka K (2016) Alginate: current use and future perspectives in pharmaceutical and biomedical applications. Int J Polym Sci 2016. Article ID 7697031, 17 pages
Tan T, Little P, Stokes T (2008) Antibiotic prescribing for self-limiting respiratory tract infections in primary care: summary of NICE guidance. BMJ 337
Tonnesen HH, Karlsen J (2002) Alginate in drug delivery systems. Drug Dev Ind Pharm 28:621–630
Torchilin V. Multifunctional pharmaceutical nanocarriers: development of the concept. In: Multifunctional pharmaceutical nanocarriers. Springer, New York, NY, 2008, pp. 1–32
Tregoning JS, Schwarze J (2010) Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology. Clin Microbiol Rev 23(1):74–98
Yang LQ, Zhang BF, Wen LQ, Liang QY, Zhang LM (2007) Amphiphilic cholesteryl grafted sodium alginate derivative: Synthesis and self-assembly in aqueous solution. Carbohydr Polym 68:218–225
Yang W, Wiederhold NP, Williams RO (2008) Drug delivery strategies for improved azole antifungal action. Expert Opin Drug Deliv 5:1199–1216
Yao BL, Ni CH, Xiong C, Zhu CP, Huang B (2010) Hydrophobic modification of sodium alginate and its application in drug controlled release. Bioprocess Biosyst Eng 33:457–463
Yehia SA, El-Gazayerly ON, Basalious EB (2009) Fluconazole mucoadhesive buccal films: in vitro/in vivo performance. Curr Drug Deliv 6(1):17–27
Yu X, Trase I, Ren M, Duval K, Guo X, Chen Z (2016) Design of nanoparticle-based carriers for targeted drug delivery. J Nanomater:15
Yuan JY, Mo BW, Ma Z, Lv Y, Cheng SL, Yang YP, Tong Z, Wu R, Sun S, Cao Z (2019) Investigator Group of the Phase 3 Study on Oral Nemonoxacin. Safety and efficacy of oral nemonoxacin versus levofloxacin in treatment of community-acquired pneumonia: a phase 3, multicenter, randomized, double-blind, double-dummy, active-controlled, non-inferiority trial. J Microbiol Immunol Infect 52(1):35–44
Zhang A, Jung K, Li A, Liu J, Boyer C (2019) Recent advances in stimuli-responsive polymer systems for remotely controlled drug release. Prog Polym Sci 99. Article ID 101164
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Gupta, R., Dan, D., Singh, A., Nimisha (2023). Alginate-Based Drug Delivery Systems for Respiratory Disease. In: Dureja, H., Adams, J., Löbenberg, R., Andreoli Pinto, T.d.J., Dua, K. (eds) Natural Polymeric Materials based Drug Delivery Systems in Lung Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-19-7656-8_19
Download citation
DOI: https://doi.org/10.1007/978-981-19-7656-8_19
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-19-7655-1
Online ISBN: 978-981-19-7656-8
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)