Abstract
The introduction of nanoscience and nanotechnology has been a pathbreaking achievement of modern science and engineering. Development and fabrication of biocompatible nanoparticles, nanocomposites, nano-scaffolds, nanowires, etc., and their stable conjugation with biological molecules indeed came out fruitful in developing nanomaterials and nanodevices for diagnosing and treating life-threatening human diseases. Nano-sized smart materials possess several unique structural and functional traits like controlled bioactivity, superior penetration ability, and sustained action over the treatment time. All these properties have led to the inclusion of several metals and non-metal derived nanomaterials as well as hybrid nanocomposites for diagnosing different infectious and inflammatory complications of humans. Nowadays, nanobiosensors can efficiently trace the affected tissues or diseased organs while targeted delivery of nanoparticles or drug-loaded nano-cargo can provide a suitable outcome within less treatment schedule. However, several important parameters of the nanocomposites like size, drug-loading methods, dose of the drug/nanoparticle-drug conjugate, and bioavailability are of major concern to yield the desired efficacy of a nanoformulation. Alteration or disproportion in any of the aforementioned parameters could induce toxic side effects. Considering all the facts, the present chapter depicts a comprehensive overview of the properties, bioactivities, molecular mode of action, and toxicity of various nanomaterials and nanodevices having the potential to diagnose and treat various inflammatory and infectious diseases in humans.
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Acknowledgements
SM thanks University Grants Commission (UGC) (Ref no. F.2-12/2019(STRIDE-1) and KNU-UGC STRIDE (Ref no. KNU/R/STRIDE/1077/21) and Department of Science and Technology-Science & Engineering Research Board (DST-SERB) (Ref no.- CRG/2021/002605) awarding research grants. Due to limited and constrained space, there are equally important publications we are unable to acknowledge (cite); however, we are also grateful to the uncited related articles/studies related to this current chapter.
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Mukherjee, N., Dey, S., Modak, B.K., Mukherjee, S. (2023). Nanomaterials and Nanodevices for Treating Human Infectious and Inflammatory Diseases: Bane or Boon for Human Health?. In: Dutta, G., Biswas, A. (eds) Next Generation Smart Nano-Bio-Devices. Smart Innovation, Systems and Technologies, vol 322. Springer, Singapore. https://doi.org/10.1007/978-981-19-7107-5_7
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