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Chitosan-Based Nanocomposite Materials pp 199–219Cite as

Chitosan-Based Nanocomposites as Remarkably Effectual Wound Healing Agents

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Abstract

In recent years, chitosan (CS), the second-most abundant biopolymer on earth, obtained by deacetylation of chitin, has garnered significant attention for its immense potential in accelerating the wound healing process. Some of its outstanding virtues such as biocompatibility, easy degradation, ability to promote collagen deposition, low cost, and non-toxic nature, combined with its antimicrobial and anti-inflammatory properties when coupled with nanomaterials like magnetic nanoparticles, render chitosan-based nanocomposites as effectual candidates in the process of wound healing. In this chapter, we briefly describe the processing techniques of chitosan-based nanocomposites, and their application as wound healing agents has been expounded. Further, significant emphasis has been given to the properties of these nanocomposites favoring the wound repair process as well as the mechanism and effects on wounds.

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Abbreviations

CAV:

Chitosan Aloe vera

CS :

Chitosan

DNA :

Deoxyribonucleic acid

ECM :

Extracellular matrix

EDTA :

Ethylenediaminetetraacetic Acid

IFN-γ :

Interferon gamma

IL-1 :

Interleukin 1

IL-10 :

Interleukin 10

IL-13 :

Interleukin 13

IL-4 :

Interleukin 4

IL-6 :

Interleukin 6

L-b-L :

Layer-by-layer

MIC :

Minimum Inhibitory Concentrations

MNPs :

Metal nanoparticles

MRSA :

Methicillin-resistant Staphylococcus aureus

NPs :

Nanoparticles

OCNP :

Drug Interaction Oral Contraceptive pill

PAA :

Polyacrylic acid

PECs :

Polyelectrolyte complexes

PLGA :

Poly D,L-lactic-co-glycolic acid

PVA :

Poly Vinyl Alcohol

PVA :

Polyvinyl alcohol

RNA :

Ribonucleic acid

ROS :

Reactive Oxygen Species

SEM :

Scanning Electron Microscope

TGF-β1 :

Transforming growth factor beta

TNF-α :

Tumour Necrosis Factor alpha

VEGF :

Vascular endothelial growth factor

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Authors and Affiliations

  1. Department of Chemistry, Sri Venkateswara College, University of Delhi, Delhi, 110021, India

    Sneha Vijayan, Shikha Gulati, Tanu Sahu,  Meenakshi & Sanjay Kumar

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  1. Sneha Vijayan
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  2. Shikha Gulati
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Correspondence to Shikha Gulati .

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  1. Department of Chemistry, Sri Venkateswara College, University of Delhi, New Delhi, Delhi, India

    Shikha Gulati

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Vijayan, S., Gulati, S., Sahu, T., Meenakshi, Kumar, S. (2022). Chitosan-Based Nanocomposites as Remarkably Effectual Wound Healing Agents. In: Gulati, S. (eds) Chitosan-Based Nanocomposite Materials. Springer, Singapore. https://doi.org/10.1007/978-981-19-5338-5_9

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