Abstract
With more research being conducted to elucidate the various molecular mechanism of cancer progression, the development of chemically synthesized drugs has greatly improved over the past decades. However, many of these drugs still come along with severe side effects that affect the patient’s quality of life. Other than these side effects, toxicity and drug resistance of conventional therapy have led researchers to look into the possibility of using plant-derived compounds as treatment strategies. Studies have shown that phytochemicals are capable of interfering with the molecular mechanisms involved in cancer cell growth and proliferation while having minimal toxicity and less detrimental side effects. While a few phytochemical derived anticancer drugs such as the analogues of vinca alkaloids and taxanes have been approved by the Food and Drug Administration (FDA) for cancer therapy, various other compounds are still in the preclinical and clinical trial stages. This chapter is a comprehensive compilation of various phytochemical agents that have been and still are being studied for the therapy of cancer with a specific focus on neuronal cancer research. These experimental beliefs are tapping into a whole new operative perspective for the neuronal cancer model which can be unleashed by further exploratory research.
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Jayaraman, M., Sivakumar, D., Dutta, P., Arora, K., Raghavendran, H.R.B., Nagarajan, K. (2023). A Study on the Role of Phytochemicals in the Preclinical Neuronal Cancer Model. In: Pathak, S., Banerjee, A., Bisgin, A. (eds) Handbook of Animal Models and its Uses in Cancer Research. Springer, Singapore. https://doi.org/10.1007/978-981-19-3824-5_31
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