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Designer Probiotics in Metabolic Disorders

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Probiotic Research in Therapeutics

Abstract

Microbes play several vital physiological and metabolic functions in human body. It has been observed that alteration in human gut microbiota has resulted in various chronic and acute metabolic diseases such as obesity, hypertension, neurogenic diseases (Parkinson’s and Alzheimer), diabetes, etc. Hence, re-establishment of microbial population, with the help of commensal probiotic bacteria, to improve the gut dysbiosis, has always been the topic of interest. Currently, with the growing knowledge of synthetic biology, genetic engineering, metabolic engineering, and other advanced tools, researchers are attempting to design recombinant probiotic strains, which are capable of carrying therapeutic molecules to the target site. These designer probiotics will enhance the efficacy of the carried molecule without showing any side effects. However, currently, the consumer acceptance of such “Designer Probiotics” is very low. The current chapter envisages a brief introduction about designer probiotics, their developmental strategies, applications of designer probiotics in regulating metabolic diseases, and the challenges in the path of their development discussing examples of few designer probiotic strains. Overall, this chapter intends to provide insight towards the development of designer probiotics to improve the human health.

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Authors and Affiliations

  1. Anton Paar India Pvt Ltd, Udyog Vihar (Phase V), Gurugram, Haryana, India

    Rishi Gupta

  2. Tropilite Foods Pvt Ltd, Davar Campus, Gwalior, Madhya Pradesh, India

    Shailendra Raghuwanshi

Authors
  1. Rishi Gupta
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  2. Shailendra Raghuwanshi
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Correspondence to Rishi Gupta .

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Editors and Affiliations

  1. University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India

    Kanwaljit Chopra

  2. National Agri-Food Biotechnology Institute, Punjab, India

    Mahendra Bishnoi

  3. National Agri-Food Biotechnology Institute, Punjab, India

    Kanthi Kiran Kondepudi

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Gupta, R., Raghuwanshi, S. (2022). Designer Probiotics in Metabolic Disorders. In: Chopra, K., Bishnoi, M., Kondepudi, K.K. (eds) Probiotic Research in Therapeutics. Springer, Singapore. https://doi.org/10.1007/978-981-16-8444-9_12

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