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Finding a Niche: Tissue Immunity and Innate Lymphoid Cells

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Innate Lymphoid Cells

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1365))

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Abstract

The immune system plays essential roles in maintaining homeostasis in mammalian tissues that extend beyond pathogen clearance and host defense. Recently, several homeostatic circuits comprised of paired hematopoietic and non-hematopoietic cells have been described to influence tissue composition and turnover in development and after perturbation. Crucial circuit components include innate lymphoid cells (ILCs), which seed developing organs and shape their resident tissues by influencing progenitor fate decisions, microbial interactions, and neuronal activity. As they develop in tissues, ILCs undergo transcriptional imprinting that encodes receptivity to corresponding signals derived from their resident tissues but ILCs can also shift their transcriptional profiles to adapt to specific types of tissue perturbation. Thus, ILC functions are embedded within their resident tissues, where they constitute key regulators of homeostatic responses that can lead to both beneficial and pathogenic outcomes. Here, we examine the interactions between ILCs and various non-hematopoietic tissue cells, and discuss how specific ILC-tissue cell circuits form essential elements of tissue immunity.

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Acknowledgements

We thank members of the Van Dyken laboratory for their insightful comments and discussion. Figures were created with BioRender.com. This work was supported by the US National Institutes of Health (R01 HL148033) and the Department of Pathology and Immunology at Washington University School of Medicine.

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  1. Haerin Jung, Do-Hyun Kim and Yilin Wang contributed equally with all other contributors.

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  1. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA

    Haerin Jung, Do-Hyun Kim, Yilin Wang & Steven J. Van Dyken

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  1. Haerin Jung
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  2. Do-Hyun Kim
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Correspondence to Steven J. Van Dyken .

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  1. Program in Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA

    Xiao-Hong Sun

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Jung, H., Kim, DH., Wang, Y., Van Dyken, S.J. (2022). Finding a Niche: Tissue Immunity and Innate Lymphoid Cells. In: Sun, XH. (eds) Innate Lymphoid Cells. Advances in Experimental Medicine and Biology, vol 1365. Springer, Singapore. https://doi.org/10.1007/978-981-16-8387-9_5

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