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Clinical Approaches in Targeting ROS-Induced Cancer

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Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

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Abstract

Reactive oxygen species (ROS) results from various metabolic processes and plays a significant role as secondary messengers across multiple signaling pathways. However, any disruption in the delicate balance of optimum ROS levels and regulatory antioxidant molecules can lead to enhanced oxidative stress, proving detrimental to the cell homeostatic functioning. The major repercussion observed in the mammalian system is the pro-tumorigenic impact of the upregulated ROS levels in tumor initiation, progression, and metastasis. Hence, robust diagnostic and prognostic tools need to be developed to screen and target ROS in cancer patients. This chapter highlights the different clinical therapies currently employed to detect and suppress the elevated ROS levels within the tumor cells. These therapies include drug-based therapies, immunotherapies, radiation-based therapies like photodynamic therapy (PDT) and sonodynamic therapy (SDT), inhibitors such as HSP90 and Mn porphyrins, and other targeted remedies like vaccines, monoclonal antibodies, and hydrogen gas application. Summarizing such commonly used clinical practices at a single platform facilitates a comparative analysis for their efficiency and adaptability.

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Authors and Affiliations

  1. Army Hospital Research and Referral (R&R), New Delhi, India

    Anugya Sengar

  2. Department of Zoology, Deshbandhu College, University of Delhi, New Delhi, India

    Manisha Sengar

  3. Stem Cell Facility, DBT Centre of Excellence for Stem Cell Research, All India Institute of Medical Sciences, New Delhi, India

    Zoya Mann

  4. Immunogenetics and Transplantation Laboratory, Department of Surgery, University of California San Francisco (UCSF), San Francisco, CA, USA

    Pawan Kumar Raghav

Authors
  1. Anugya Sengar
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  2. Manisha Sengar
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  3. Zoya Mann
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  4. Pawan Kumar Raghav
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Editor information

Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

Section Editor information

  1. Cellular Stress and Immune Response Laboratory, Centre for Cancer Biology, University of South Australia, Adelaide, South Australia, Australia

    Nirmal Robinson

  2. Department of Morphofunctional Sciences, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania

    Cornelia Amalinei

  3. Department of Applied Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana State, India

    Amitava Das

  4. Biological Sciences, Academy of Scientific and Innovative Research, Ghaziabad,, UP, India

    Amitava Das

  5. Chettinad Hospital & Research Institute (CHRI), Chettinad Academy of Research and Education (CARE), Chennai, Tamil Nadu, India

    Surajit Pathak

  6. Stem Cell Facility, DBT-Centre of Excellence for Stem Cell Research, All India Institute of Medical Sciences, New Delhi, India

    Sujata Mohanty

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Sengar, A., Sengar, M., Mann, Z., Raghav, P.K. (2022). Clinical Approaches in Targeting ROS-Induced Cancer. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-5422-0_256

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