Skip to main content
SpringerLink
Log in

Polyphenols and Nutrition: Nanotherapeutic and Immunomodulatory Implications in Cancer

  • Chapter
  • First Online:
Polyphenols-based Nanotherapeutics for Cancer Management

  • 409 Accesses

Abstract

Polyphenols are plant-based compounds and natural products which, increasingly, have been gaining traction due to their diverse roles as therapeutics, food supplements, and preservatives. Despite their occurrence only in plants, polyphenols are increasingly finding their use in various foods—seafood, meats, and plant products—to enhance their flavor, texture, shelf-life, and overall quality. As therapeutics, polyphenols have been shown to possess antioxidant and anti-inflammatory properties. As a result, they have been used as therapeutic and/or treatment agents directly and/or in combination with other compounds for the treatment of many cancers, metabolic diseases, neurodegenerative diseases, and inflammation. Oxidation is a phenomenon characterized by the loss of oxygen leading to oxidative stress which can compromise the detoxifying capabilities of biological systems. Oxidative stress has been implicated in the damage/disruption of DNA function including DNA-repair mechanism, cellular structure, lipid membrane bilayer, and protein-folding. Maintaining an equilibrium between cell death and cell survival is necessary for an organism to remain healthy—increased cell death can lead to tissue deterioration while increased cell survival can lead to cancer. Polyphenols, the most abundant antioxidants and anti-inflammatory agents in human diets, play important therapeutic roles in oxidative stress by terminating the oxidation chain reactions to retain cell viability, function, and molecular signaling pathways. In this chapter, the author explores the following three areas: (1) Polyphenols and their role in nutrition, (2) Nutrition focusing on fish and other seafood-based diets enhanced with polyphenols, and (3) Role of polyphenols as immune/chemotherapeutic agents in cancer treatment and prevention.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Bravo L. Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr Rev. 1998;56(11):317–33. https://doi.org/10.1111/j.1753-4887.1998.tb01670.x. PMID: 9838798

    Article  CAS  PubMed  Google Scholar 

  2. Manach C, Scalbert A, Morand C, Rémésy C, Jiménez L. Polyphenols: food sources and bioavailability. Am J Clin Nutr. 2004;79(5):727–47.

    Article  CAS  Google Scholar 

  3. Marranzano M, Rosa RL, Malaguarnera M, Palmeri R, Tessitori M, Barbera AC. Polyphenols: plant sources and food industry applications. Curr Pharm Des. 2018;24(35):4125–30.

    Article  CAS  Google Scholar 

  4. Dabas D. Polyphenols as colorants. Adv Food Technol Nutr Sci Open J. 2016;SE(2):S1–6. https://doi.org/10.17140/AFTNSOJ-SE-2-101.

    Article  Google Scholar 

  5. Auad P, Spier F, Gutterres M. Vegetable tannin composition and its association with the leather tanning effect. Chem Eng Commun. 2020;207(5):722–32. https://doi.org/10.1080/00986445.2019.1618843.

    Article  CAS  Google Scholar 

  6. Kharissova OV, Kharisov BI, Oliva González CM, Méndez YP, López I. Greener synthesis of chemical compounds and materials. R Soc Open Sci. 2019;6(11):191378. https://doi.org/10.1098/rsos.191378.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Ambriz-Pérez DL, Leyva-López N, Gutierrez-Grijalva EP, Heredia JB, Yildiz F. Phenolic compounds: natural alternative in inflammation treatment. A review. Cogent Food Agric. 2016;2:1. https://doi.org/10.1080/23311932.2015.1131412.

    Article  CAS  Google Scholar 

  8. Sobhani M, Farzaei MH, Kiani S, Khodarahmi R. Immunomodulatory; anti-inflammatory/antioxidant effects of polyphenols: a comparative review on the parental compounds and their metabolites. Food Rev Int. 2020; https://doi.org/10.1080/87559129.2020.1717523.

  9. Hussain T, Tan B, Yin Y, Blachier F, Tossou MC, Rahu N. Oxidative stress and inflammation: What polyphenols can do for us? Oxid Med Cell Longev. 2016;2016:7432797. https://doi.org/10.1155/2016/7432797.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Magrone T, Magrone M, Russo MA, Jirillo E. Recent advances on the anti-inflammatory and antioxidant properties of red grape polyphenols: in vitro and in vivo studies. Antioxidants (Basel). 2019;9(1):35. https://doi.org/10.3390/antiox9010035.

    Article  CAS  PubMed Central  Google Scholar 

  11. Perez-Jimenez J, Neveu V, Vos F, Scalbert A. Identification of the 100 richest dietary sources of polyphenols: an application of the phenol-explorer database. Eur J Clin Nutr. 2010;64(Suppl. 3):S112–20. https://doi.org/10.1038/ejcn.2010.221.

    Article  CAS  PubMed  Google Scholar 

  12. McCord JM. The evolution of free radicals and oxidative stress. Am J Med. 2000;108(8):652–9. https://doi.org/10.1016/s0002-9343(00)00412-5.

    Article  CAS  PubMed  Google Scholar 

  13. Del Rio D, Rodriguez-Mateos A, Spencer JP, et al. Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid Redox Signal. 2013;18:1818–92.

    Article  Google Scholar 

  14. Cory H, Passarelli S, Szeto J, Tamez M, Mattei J. The role of polyphenols in human health and food systems: a mini review. Front Nutr. 2018;5:87. https://doi.org/10.3389/fnut.2018.00087.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Tsao R. Chemistry and biochemistry of dietary polyphenols. Nutrients. 2010;2(12):1231–46. https://doi.org/10.3390/nu2121231.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Durazzo A, Lucarini M, Souto EB, et al. Polyphenols: a concise overview on the chemistry, occurrence, and human health. Phytother Res. 2019;33:2221–43. https://doi.org/10.1002/ptr.6419.

    Article  PubMed  Google Scholar 

  17. Scalbert A, Williamson G. Dietary intake and bioavailability of polyphenols. J Nutr. 2000;130(8):2073S–85S. https://doi.org/10.1093/jn/130.8.2073S.

    Article  CAS  PubMed  Google Scholar 

  18. Phenol-Explorer. Phenol-Explorer: an online comprehensive database on polyphenol contents in foods; 2010. Available at http://www.phenol-explorer.eu

  19. Tangney CC, Rasmussen HE. Polyphenols, inflammation, and cardiovascular disease. Curr Atheroscler Rep. 2013;15(5) https://doi.org/10.1007/s11883-013-0324-x.

  20. Hanhineva K, Törrönen R, Bondia-Pons I, et al. Impact of dietary polyphenols on carbohydrate metabolism. Int J Mol Sci. 2010;11(4):1365–402. https://doi.org/10.3390/ijms11041365.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Amiot MJ, Riva C, Vinet A. Effects of dietary polyphenols on metabolic syndrome features in humans: a systematic review. Obes Rev. 2016;17(7):573–−86.

    Article  CAS  Google Scholar 

  22. Williamson G. The role of polyphenols in modern nutrition. Nutr Bull. 2017;42(3):226–35. https://doi.org/10.1111/nbu.12278.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Bleich SN, Cutler D, Murray C, Adams A. Why is the developed world obese? Annu Rev Publ Health. 2008;29(1):273–95.

    Article  Google Scholar 

  24. Kolb H, Martin S. Environmental/lifestyle factors in the pathogenesis and prevention of type 2 diabetes. BMC Med. 2017;15(1):131. https://doi.org/10.1186/s12916-017-0901-x.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Safer JD, Coleman E, Feldman J, et al. Barriers to healthcare for transgender individuals. Curr Opin Endocrinol Diabetes Obes. 2016;23(2):168–71. https://doi.org/10.1097/MED.0000000000000227.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Corella D, Coltell O, Portolés O, et al. A guide to applying the sex-gender perspective to nutritional genomics. Nutrients. 2018;11(1):4. https://doi.org/10.3390/nu11010004.

    Article  PubMed Central  Google Scholar 

  27. Rochlani Y, Pothineni NV, Kovelamudi S, Mehta JL. Metabolic syndrome: pathophysiology, management, and modulation by natural compounds. Ther Adv Cardiovasc Dis. 2017;11(8):215–25. https://doi.org/10.1177/1753944717711379.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. McCracken E, Monaghan M. Sreenivasan S. Pathophysiology of the metabolic syndrome. Clin Dermatol. 2018;36(1):14–20. https://doi.org/10.1016/j.clindermatol.2017.09.004. Epub 2017 Sep 8. PMID: 29241747

    Article  PubMed  Google Scholar 

  29. Larsson SC, Wolk A. Meat consumption and risk of colorectal cancer: a meta-analysis of prospective studies. Int J Cancer. 2006;119(11):2657–64. https://doi.org/10.1002/ijc.22170.

    Article  CAS  PubMed  Google Scholar 

  30. Aguilar-Salinas CA, Viveros-Ruiz T. Recent advances in managing/understanding the metabolic syndrome. F1000Res. 2019;8:F1000 Faculty Rev-370. https://doi.org/10.12688/f1000research.17122.1.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Bower A, Imbard A, Benoist JF, Pichard S, Rigal O, Baud O, Schiff M. Diagnostic contribution of metabolic workup for neonatal inherited metabolic disorders in the absence of expanded newborn screening. Sci Rep. 2019;9(1):14098. https://doi.org/10.1038/s41598-019-50518-0. PMID: 31575911; PMCID: PMC6773867

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Boyer SW, Barclay LJ, Burrage LC. Inherited metabolic disorders: aspects of chronic nutrition management. Nutr Clin Pract. 2015;30(4):502–10. https://doi.org/10.1177/0884533615586201.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Agana M, Frueh J, Kamboj M, Patel DR, Kanungo S. Common metabolic disorder (inborn errors of metabolism) concerns in primary care practice. Ann Transl Med. 2018;6(24):469. https://doi.org/10.21037/atm.2018.12.34.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Ravasco P. Nutrition in cancer patients. J Clin Med. 2019;8(8):1211. https://doi.org/10.3390/jcm8081211.

    Article  CAS  PubMed Central  Google Scholar 

  35. Coa KI, Epstein JB, Ettinger D, et al. The impact of cancer treatment on the diets and food preferences of patients receiving outpatient treatment. Nutr Cancer. 2015;67(2):339–53. https://doi.org/10.1080/01635581.2015.990577.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Catany Ritter A, Egger AS, Machacek J, Aspalter R. Impact of elimination or reduction of dietary animal proteins on cancer progression and survival: protocol of an online pilot cohort study. JMIR Res Protoc. 2016;5(3):e157. https://doi.org/10.2196/resprot.5804.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Jassem J. Tobacco smoking after diagnosis of cancer: clinical aspects. Transl Lung Cancer Res. 2019;8(Suppl 1):S50–8. https://doi.org/10.21037/tlcr.2019.04.01.

    Article  PubMed  PubMed Central  Google Scholar 

  38. The European Prospective Investigation into Cancer and Nutrition (EPIC) study [Internet]. Highlights. 2021. Available from: https://epic.iarc.fr/. Cited 15 Jan 2021.

  39. Bradbury KE, Appleby PN, Key TJ. Fruit, vegetable, and fiber intake in relation to cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC). Am J Clin Nutr. 2014;100(1):394S–8S. https://doi.org/10.3945/ajcn.113.071357.

    Article  CAS  PubMed  Google Scholar 

  40. Silva RFM, Pogačnik L. Polyphenols from food and natural products: neuroprotection and safety. Antioxidants (Basel). 2020;9(1):61. https://doi.org/10.3390/antiox9010061.

    Article  CAS  PubMed Central  Google Scholar 

  41. Mei J, Ma X, Xie J. Review on natural preservatives for extending fish shelf life. Foods. 2019;8(10):490. https://doi.org/10.3390/foods8100490.

    Article  CAS  PubMed Central  Google Scholar 

  42. Balasch JC, Tort L. Netting the stress responses in fish. Front Endocrinol (Lausanne). 2019;10:62. https://doi.org/10.3389/fendo.2019.00062.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Oniszczuk T, Oniszczuk A, Gondek E, Guz L, Puk K, Kocira A, et al. Active polyphenolic compounds, nutrient contents and antioxidant capacity of extruded fish feed containing purple coneflower (Echinacea purpurea (L.) Moench.). Saudi J Biol Sci. 2019;26(1):24–30. https://doi.org/10.1016/j.sjbs.2016.11.013. Epub 2016 Nov 22. PMID: 30622403; PMCID: PMC6318779

    Article  CAS  PubMed  Google Scholar 

  44. Maqsood S, Benjakul S, Shahidi F. Emerging role of phenolic compounds as natural food additives in fish and fish products. Crit Rev Food Sci Nutr. 2013;53(2):162–79. https://doi.org/10.1080/10408398.2010.518775. PMID: 23072531

    Article  CAS  PubMed  Google Scholar 

  45. Forman HJ, Ursini F, Maiorino M. An overview of mechanisms of redox signaling. J Mol Cell Cardiol. 2014;73:2–9. https://doi.org/10.1016/j.yjmcc.2014.01.018. Epub 2014 Feb 8. PMID: 24512843; PMCID: PMC4048798

    Article  CAS  PubMed  Google Scholar 

  46. Hannukainen JC, Lautamäki R, Mari A, Pärkkä JP, Bucci M, Guzzardi MA, et al. Elevated glucose oxidation, reduced insulin secretion, and a fatty heart may be protective adaptions in ischemic CAD. J Clin Endocrinol Metab. 2016;101(7):2701–10. https://doi.org/10.1210/jc.2015-4091. Epub 2016 Apr 5. PMID: 27045985; PMCID: PMC4929844

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Wölfle U, Seelinger G, Bauer G, Meinke MC, Lademann J, Schempp CM. Reactive molecule species and antioxidative mechanisms in normal skin and skin aging. Skin Pharmacol Physiol. 2014;27(6):316–32. https://doi.org/10.1159/000360092.

    Article  CAS  PubMed  Google Scholar 

  48. Bild W, Ciobica A, Padurariu M, Bild V. The interdependence of the reactive species of oxygen, nitrogen, and carbon. J Physiol Biochem. 2013;69(1):147–54. https://doi.org/10.1007/s13105-012-0162-2. Epub 2012 Mar 29. PMID: 22456998

    Article  CAS  PubMed  Google Scholar 

  49. Gaschler MM, Stockwell BR. Lipid peroxidation in cell death. Biochem Biophys Res Commun. 2017;482(3):419–25. https://doi.org/10.1016/j.bbrc.2016.10.086.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  50. Li H, Zhou X, Gao P, et al. Inhibition of lipid oxidation in foods and feeds and hydroxyl radical-treated fish erythrocytes: A comparative study of Ginkgo biloba leaves extracts and synthetic antioxidants. Anim Nutr. 2016;2(3):234–41. https://doi.org/10.1016/j.aninu.2016.04.007.

    Article  PubMed  PubMed Central  Google Scholar 

  51. Ehsani A, Jasour MS. Improvement of lipid stability of refrigerated rainbow trout (Oncorhynchus mykiss) fillets by pre-storage α-tocopherol acetate dipping treatment. Vet Res Forum. 2012;3(4):269–73.

    PubMed  PubMed Central  Google Scholar 

  52. Gamba P, Staurenghi E, Testa G, Giannelli S, Sottero B, Leonarduzzi G. A crosstalk between brain cholesterol oxidation and glucose metabolism in Alzheimer’s disease. Front Neurosci. 2019;13:556. https://doi.org/10.3389/fnins.2019.00556.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Leri M, Scuto M, Ontario ML, et al. Healthy effects of plant polyphenols: molecular mechanisms. Int J Mol Sci. 2020;21(4):1250. https://doi.org/10.3390/ijms21041250.

    Article  CAS  PubMed Central  Google Scholar 

  54. Brglez Mojzer E, Knez Hrnčič M, Škerget M, Knez Ž, Bren U. Polyphenols: Extraction methods, antioxidative action, bioavailability and anticarcinogenic effects. Molecules. 2016;21(7):901. https://doi.org/10.3390/molecules21070901.

    Article  CAS  PubMed Central  Google Scholar 

  55. Lorenzo JM, Mousavi-Khaneghah A, Gavahian M, Marszałek K, Eş I, Munekata PES, et al. Understanding the potential benefits of thyme and its derived products for food industry and consumer health: from extraction of value-added compounds to the evaluation of bioaccessibility, bioavailability, anti-inflammatory, and antimicrobial activities. Crit Rev Food Sci Nutr. 2019;59(18):2879–95. https://doi.org/10.1080/10408398.2018.1477730.

    Article  CAS  PubMed  Google Scholar 

  56. National Cancer Institute [Internet]. What is cancer? Available from: https://www.cancer.gov/about-cancer/understanding/what-is-cancer. Cited 15 Jan 2021.

  57. Global Burden of Disease [Internet]. Global burden of disease (GBD). Available from: http://www.healthdata.org/gbd/2019. Cited 15 Jan 2021.

  58. Cancer – World Health Organization [Internet]. Cancer. Available from: https://www.who.int/news-room/fact-sheets/detail/cancer. Cited 15 Jan 2021.

  59. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359–86. https://doi.org/10.1002/ijc.29210.

    Article  CAS  PubMed  Google Scholar 

  60. Wei Y, Wu B, Jiang W, Yin T, Jia X, Basu S, Yang G, Hu M. Revolving door action of breast cancer resistance protein (BCRP) facilitates or controls the efflux of flavone glucuronides from UGT1A9-overexpressing HeLa cells. Mol Pharm. 2013;10(5):1736–50.

    Article  CAS  Google Scholar 

  61. Afshari K, Haddadi NS, Haj-Mirzaian A, Farzaei MH, Rohani MM, Akramian F, et al. Natural flavonoids for the prevention of colon cancer: a comprehensive review of preclinical and clinical studies. J Cell Physiol. 2019;234:21519–46. https://doi.org/10.1002/jcp.28777.

    Article  CAS  PubMed  Google Scholar 

  62. Messerschmidt JL, Prendergast GC, Messerschmidt GL. How cancers escape immune destruction and mechanisms of action for the new significantly active immune therapies: helping nonimmunologists decipher recent advances. Oncologist. 2016;21(2):233–43. https://doi.org/10.1634/theoncologist.2015-0282.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. Gonzalez H, Hagerling C, Werb Z. Roles of the immune system in cancer: from tumor initiation to metastatic progression. Genes Dev. 2018;32(19–20):1267–84. https://doi.org/10.1101/gad.314617.118.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  64. Soldati L, Di Renzo L, Jirillo E, Ascierto PA, Marincola FM, De Lorenzo A. The influence of diet on anti-cancer immune responsiveness. J Transl Med. 2018;16(1):75. https://doi.org/10.1186/s12967-018-1448-0.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  65. Malech HL, Deleo FR, Quinn MT. The role of neutrophils in the immune system: an overview. Methods Mol Biol. 2014;1124:3–10. https://doi.org/10.1007/978-1-62703-845-4_1.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  66. Crotty S. A brief history of T cell help to B cells. Nat Rev Immunol. 2015;15(3):185–9. https://doi.org/10.1038/nri3803.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. Petersone L, Edner NM, Ovcinnikovs V, et al. T cell/B cell collaboration and autoimmunity: an intimate relationship. Front Immunol. 2018;9:1941. https://doi.org/10.3389/fimmu.2018.01941.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  68. Yahfoufi N, Alsadi N, Jambi M, Matar C. The immunomodulatory and anti-inflammatory role of polyphenols. Nutrients. 2018;10(11):1618. https://doi.org/10.3390/nu10111618.

    Article  CAS  PubMed Central  Google Scholar 

  69. Niedzwiecki A, Roomi MW, Kalinovsky T, Rath M. Anticancer efficacy of polyphenols and their combinations. Nutrients. 2016;8(9):552. https://doi.org/10.3390/nu8090552.

    Article  CAS  PubMed Central  Google Scholar 

  70. Sak K. Cytotoxicity of dietary flavonoids on different human cancer types. Pharmacogn Rev. 2014;8(16):122–46. https://doi.org/10.4103/0973-7847.134247.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  71. Zhou Y, Zheng J, Li Y, et al. Natural polyphenols for prevention and treatment of cancer. Nutrients. 2016;8(8):515. https://doi.org/10.3390/nu8080515.

    Article  CAS  PubMed Central  Google Scholar 

  72. Keating E, Martel F. Antimetabolic effects of polyphenols in breast cancer cells: focus on glucose uptake and metabolism. Front Nutr. 2018;5:25. https://doi.org/10.3389/fnut.2018.00025.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  73. Avtanski D, Poretsky L. Phyto-polyphenols as potential inhibitors of breast cancer metastasis. Mol Med. 2018;24:29. https://doi.org/10.1186/s10020-018-0032-7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. Losada-Echeberría M, Herranz-López M, Micol V, Barrajón-Catalán E. Polyphenols as promising drugs against main breast cancer signatures. Antioxidants (Basel). 2017;6(4):88. https://doi.org/10.3390/antiox6040088.

    Article  CAS  PubMed Central  Google Scholar 

  75. Costea T, Nagy P, Ganea C, Szöllősi J, Mocanu MM. Molecular mechanisms and bioavailability of polyphenols in prostate cancer. Int J Mol Sci. 2019;20(5):1062. https://doi.org/10.3390/ijms20051062.

    Article  CAS  PubMed Central  Google Scholar 

  76. Miyata Y, Shida Y, Hakariya T, Sakai H. Anti-cancer effects of green tea polyphenols against prostate cancer. Molecules. 2019;24(1):193. https://doi.org/10.3390/molecules24010193.

    Article  CAS  PubMed Central  Google Scholar 

  77. Godos J, Vitale M, Micek A, Ray S, Martini D, Del Rio D, Riccardi G, Galvano F, Grosso G. Dietary polyphenol intake, blood pressure, and hypertension: a systematic review and meta-analysis of observational studies. Antioxidants. 2019;8:152. https://doi.org/10.3390/antiox8060152.

    Article  CAS  PubMed Central  Google Scholar 

  78. Rienks J, Barbaresko J, Nöthlings U. Association of polyphenol biomarkers with cardiovascular disease and mortality risk: a systematic review and meta-analysis of observational studies. Nutrients. 2017;9:415.

    Article  Google Scholar 

  79. Fraga CG, Croft KD, Kennedy DO, Tomás-Barberán FA. The effects of polyphenols and other bioactives on human health. Food Funct. 2019;10:514–28. https://doi.org/10.1039/C8FO01997E.

    Article  CAS  PubMed  Google Scholar 

  80. Briguglio G, Costa C, Pollicino M, Giambò F, Catania S, Fenga C. Polyphenols in cancer prevention: new insights (Review). Int J Funct Nutr. 2020;1:9. https://doi.org/10.3892/ijfn.2020.9.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Zoology, Women’s College, Aligarh Muslim University, Aligarh, India

    Fauzia A. Sherwani

Authors
  1. Fauzia A. Sherwani
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia

    Shams Tabrez

  2. Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia

    Mohammad Imran Khan

Rights and permissions

Reprints and permissions

Copyright information

© 2021 The Author(s), under exclusive licence to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Sherwani, F.A. (2021). Polyphenols and Nutrition: Nanotherapeutic and Immunomodulatory Implications in Cancer. In: Tabrez, S., Imran Khan, M. (eds) Polyphenols-based Nanotherapeutics for Cancer Management. Springer, Singapore. https://doi.org/10.1007/978-981-16-4935-6_9

Download citation

Publish with us

Policies and ethics

Search

Navigation