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Microbial Nanotechnology in Treating Multidrug-Resistance Pathogens

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Microbial Nanotechnology: Green Synthesis and Applications

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Abstract

Multidrug-resistant organisms (MDROs) such as viruses, bacteria, fungi, and parasites have caused significant mortalities worldwide. The continuous misusing of antimicrobial drugs is menacingly emerging infectious diseases that are resistant and difficult to treat. Many mechanisms of resistance have evolved in pathogens to avoid the bioactivities of drugs. Unfortunately, the development of new antibiotics has been limited, owing to the low economic benefits. This has motivated scientists to develop new and novel therapeutic alternatives capable of combating MDROs. Microbial nanotechnology has emerged as one of the most promising alternative therapies to overcome the crisis of antimicrobial resistance. The utilization of nanoparticles (NPs) based materials provides a new class of antimicrobial agents that transcends conventional antibiotic therapy. There are enormous advantages of antimicrobial NPs such as large surface area, direct contact to cell membranes, good biofilm penetration and can be considered as efficient drug delivery systems. Microbial synthesized NPs have shown a great potency, unique physicochemical properties, and easy to synthesis in more eco-friendly method, that have made them ideal antimicrobial agents for combating MDROs. In this chapter, an overview of microbial multidrug-resistant mechanisms and the new therapeutic alternatives to overcome these resistant microorganisms will be explored. The role of microbial NPs in combating various sensitive and resistant microbes, the advantages and challenges that can arise from their application will be highlighted.

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Authors and Affiliations

  1. National Center for Biotechnology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia

    Ahmed J. Al-Fahad, Ahmad M. Aldossary, Mohammad N. Alomary & Sami Alyahya

  2. National Center for Pharmaceutical Technology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia

    Abdullah A. Alshehri, Fahad A. Almughem & Essam A. Tawfik

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  1. Ahmed J. Al-Fahad
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  2. Ahmad M. Aldossary
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  3. Abdullah A. Alshehri
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    Mohammad Azam Ansari

  2. Institute for Research & Medical Consultations, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia

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Al-Fahad, A.J. et al. (2021). Microbial Nanotechnology in Treating Multidrug-Resistance Pathogens. In: Ansari, M.A., Rehman, S. (eds) Microbial Nanotechnology: Green Synthesis and Applications. Springer, Singapore. https://doi.org/10.1007/978-981-16-1923-6_10

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