Abstract
Cancer is one of the leading diseases worldwide and available data has confirmed that various factors like smoking, exposure to UV radiation, drinking alcohol, etc. are implicated in the pathogenesis of cancer. Presence of two or more causative factors together makes the individual more prone to the development of cancer. Among the reported etiological factors, circadian rhythm disturbances play a significant role in the pathogenesis of cancer. Available literature strongly supports the role of altered circadian rhythm in initiation, promotion, and progression of cellular changes culminating in their malignant conversion. Production of reactive oxygen species leading to oxidative stress is identified as another trigger of malignant change. Oxidative stress is also substantiated to be a critical contributor to the incidence and prevalence of cancer. This role of oxidative stress in the etiopathogenesis of cancer is corroborated by much literature.
Hence, both circadian dysregulation and oxidative stress act as independent factors in the emergence of cancer. However, interplay between them, cumulative effect, and exact mechanism are currently under research. The scope of this chapter is to discuss proposed links between circadian rhythm and oxidative stress contributing to cancer genesis. One link explores the contribution of circadian clock and various redox reactions in regulating metabolism and integration of nutritional signaling through transcriptional remodeling, which are critical for the development of cancer. Several proteins and enzymes sharing a common pathway between circadian rhythmicity and the production of reactive oxygen species in cancer formation are further proof to the aforesaid statement. It also concludes beyond doubt that circadian rhythm and oxidative stress exhibit a cumulative effect leading to a spike in various cancers and in severity of disease.
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Abdul Bari, A.B., Samuel, P.J. (2022). The Link between Circadian Rhythm and ROS-Induced Cancer. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-1247-3_215-1
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