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The Role of H2S in the Gastrointestinal Tract and Microbiota

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Advances in Hydrogen Sulfide Biology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1315))

Abstract

The pathways and mechanisms of the production of H2S in the gastrointestinal tract are briefly described, including endogenous H2S produced by the organism and H2S from microorganisms in the gastrointestinal tract. In addition, the physiological regulatory functions of H2S on gastrointestinal motility, sensation, secretion and absorption, endocrine system, proliferation and differentiation of stem cells, and the possible mechanisms involved are introduced. In view of the complexity of biosynthesis, physiological roles, and the mechanism of H2S, this chapter focuses on the interactions and dynamic balance among H2S, gastrointestinal microorganisms, and the host. Finally, we focus on some clinical gastrointestinal diseases, such as inflammatory bowel disease, colorectal cancer, functional gastrointestinal disease, which might occur or develop when the above balance is broken. Pharmacological regulation of H2S or the intestinal microorganisms related to H2S might provide new therapeutic approaches for some gastrointestinal diseases.

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Abbreviations

3-MP:

3-Mercaptopyruvate

3-MST:

3-Mercaptopyruvate sulfurtransferase

AC:

Adenylate cyclase

AOAA:

Amino-oxyacetic acid

Apr:

Adenosine-5′-phosphosulfate reductase

APS:

Adenosine-phosphosulphate

BCA:

β-cyano-l-alanine

CAT:

Cysteine aminotransferase

CBS:

Cystathionine β-synthase

CD:

Crohn’s disease

CRC:

Colorectal cancer

CRD:

Colorectal distension

CSE:

Cystathionine γ-lyase

CT:

Cholera toxin

CVH:

Chronic visceral hyperalgesia

DADS:

Diallyl disulfide

DAO:

D-amino acid oxidase

DRG:

Dorsal root ganglia

Dsr:

Dissimilatory sulfite reductase

DSS:

Dextran sodium sulfate

FD:

Functional dyspepsia

FGID:

Functional gastrointestinal diseases

H2S:

Hydrogen sulfide

HAEC:

Congenital megacolon-associated enterocolitis

HSCR:

Congenital hirschsprung disease

IBS:

Irritable bowel syndrome

ICCs:

Interstitial cells of Cajal

IJP:

Inhibitory junction potential

ISCs:

Intestinal stem cells

LDHA:

Lactate dehydrogenase A

L-NAME:

N(G)-Nitro-l-Arginine Methyl Ester

MDSCs:

Marrow-derived suppressor cells

MLCP:

Myosin light chain phosphatase

MP:

Myenteric plexus

NANC:

Noncholinergic and nonadrenergic

NCI:

Neonatal colitis

NMD:

Neonatal maternal deprivation

NOS:

Nitric oxide synthase

NSAID:

Non-steroidal anti-inflammatory drugs

PAG:

dl-propargylglycine

SMP:

Submuscular plexus

SQR:

Sulfide quinone oxidoreductase

SRB:

Sulfate-reducing bacteria

TEA:

Tetraethylamine

TLR:

Toll-like receptor

TRPA1:

Transient receptor potential ankyrin 1 channel

TRPV1:

Transient receptor potential vanilloid 1

UC:

Ulcerative colitis

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Acknowledgments

This work was supported by Liang Fan (Obstetrics and Gynecology Hospital of Fudan University) in sketch drawing.

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The authors declare no potential conflicts of interest.

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  1. Department of Physiology, Hubei College of Chinese Medicine, Jingzhou, China

    Ailin Xiao

  2. Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China

    Chuanyong Liu & Jingxin Li

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Correspondence to Jingxin Li .

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  1. Department of Physiology and Pathophysiology, Fudan University Shanghai Medical College, Shanghai Key Laboratory of Bioactive Small Molecules, School of Basic Medical Sciences, Shanghai, China

    Yi-Chun Zhu

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Xiao, A., Liu, C., Li, J. (2021). The Role of H2S in the Gastrointestinal Tract and Microbiota. In: Zhu, YC. (eds) Advances in Hydrogen Sulfide Biology. Advances in Experimental Medicine and Biology, vol 1315. Springer, Singapore. https://doi.org/10.1007/978-981-16-0991-6_4

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