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ROS at the Intersection of Inflammation and Immunity in Cancer

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Book cover Handbook of Oxidative Stress in Cancer: Mechanistic Aspects

Abstract

Oxidative stress is a result of reactive oxygen species (ROS) which are produced in various pathways as a by-product of oxygen metabolism. Major sources of ROS production are mitochondria and NOX proteins. Inflammation and immunity are critical contributors of diseases such as cancer and neurodegeneration. ROS is interconnected with inflammation and immunity in cancer through pathways related to hypoxia and pattern recognition receptors. Cancer cells produce huge amount of ROS which in turn stabilizes HIF-1α and promotes tumor growth and invasion. HIF-1α regulates ROS levels in cancer cells below the toxicity and thereby promotes its growth. Current literature lacks in exploring the interplay of hypoxia, ROS, and NLRs in cancer. Exploring these interactions will pave for the better therapeutic development. Enhancing the oxidative stress levels above toxicity along with anti-hypoxic drugs can be an efficient therapeutic regime for the cancer.

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Authors and Affiliations

  1. Department of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur, Jodhpur, Rajasthan, India

    Shivanjali Saxena & Sushmita Jha

Authors
  1. Shivanjali Saxena
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  2. Sushmita Jha
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Correspondence to Sushmita Jha .

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Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, USA

    Bimal K. Ray

  3. CSIR-Indian Institute of Chemical Biology, Kolkata, India

    Susanta Roychoudhury

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Saxena, S., Jha, S. (2022). ROS at the Intersection of Inflammation and Immunity in Cancer. In: Chakraborti, S., Ray, B.K., Roychoudhury, S. (eds) Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-15-9411-3_64

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