Abstract
The Indo-Pak region has deep historical roots of traditional medicine. In both Pakistan and India, the local population has relied upon the Unani-Tibb (Graeco-Arabic) and Ayurveda medicinal systems for centuries. With the increase in our understanding of ethnobotany and endophytes, the significance of the traditional plants in the region has also increased. The traditional Indo-Pak plants such as Neem and Tulsi have been studied not only for their wide array of pharmaceutical activities but also for their endophytes. Extracts of different parts of neem have been used as antimicrobial, antiviral, antimalarial, anti-carcinogenic, antipyretic, anti-ulcer and anti-inflammatory agents, whereas its seeds are a rich source of proteins and fatty acids. Latest researches have proved the nutraceutical potential of plants such as imli, amla and soanjna in the Indo-Pak region. Further understanding of these plants can lead to unbeatable bioactive and nutraceutical sources. In this chapter, we will focus on the traditional plants of the Indo-Pak region, their endophytes particularly the genus actinomycetes and the recent studies done on their diverse metabolites.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Abdallah M, Muhammad A (2018) Antibacterial activity of leaves and fruit extract of Tamarindus indica against clinical isolates of Escherichia coli and Shigella at Potiskum Yobe state. Nigeria J Anal Pharma Res 7:606–609
Abdulhamza N (2013) Study of phytochemical composition and antibacterial activity of Emblica officinalis (Amla) fruit extract. AJVS 6:107–113
Abdull Razis AF, Ibrahim MD, Kntayya SB (2014) Health benefits of Moringa oleifera. Asian Pac J Cancer Prev 15:8571–8576
Ahmad SS, Husain SZ (2008) Ethno medicinal survey of plants from salt range (Kallar Kahar) of Pakistan. Pak J Bot 40:1005–1011
Ahmed M et al (2020) Exploring the antioxidant potential of some common marketed nutraceuticals/drugs in Pakistan by different in vitro models. Lat Am J Pharm 39:372–375
Akshatha V, Nalini M, D’Souza C, Prakash H (2014) Streptomycete endophytes from anti-diabetic medicinal plants of the Western Ghats inhibit alpha-amylase and promote glucose uptake. Lett Appl Microbiol 58:433–439
Akshatha JV, Prakash HS, Nalini MS (2016) Actinomycete endophytes from the ethno medicinal plants of southern India: antioxidant activity and characterization studies. JBAPN 6:166–172
Al-Samarrai G, Singh H, Syarhabil M (2012) Evaluating eco-friendly botanicals (natural plant extracts) as alternatives to synthetic fungicides. Ann Agric Environ Med 19:673–676
Androutsopoulos VP, Tsatsakis AM, Spandidos DA (2009) Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention. BMC Cancer 9:187
Arora DS, Kaur N (2019) Antimicrobial potential of fungal endophytes from Moringa oleifera. Appl Biochem Biotechnol 187:628–648
Asare GA et al (2012) Toxicity potentials of the nutraceutical Moringa oleifera at supra-supplementation levels. J Ethnopharmacol 139:265–272
Ashok Kumar N, Pari L (2003) Antioxidant action of Moringa oleifera Lam. (drumstick) against antitubercular drugs induced lipid peroxidation in rats. J Med Food 6:255–259
Asif M (2012) Antimicrobial potential of Azadirachta indica against pathogenic bacteria and fungi. J Pharmacogn Phytochem 1:78–83
Asif M, Mohd I (2019) Prospects of medicinal plants derived nutraceuticals: a re-emerging new era of medicine and health aid. PCBR 2:150–169
Atri N, Rai N, Singh AK, Verma M, Barik S, Gautam V, Singh SK (2020) Screening for endophytic fungi with antibacterial efficiency from Moringa oleifera and Withania somnifera. J Sci Res 64:127–133
Bagul M, Sonawane SK, Arya SS (2015) Tamarind seeds: chemistry, technology, applications and health benefits. Indian Food Ind Mag 34:28–35
Basit A, Fawwad A, Baqa K (2019) Pakistan and diabetes—a country on the edge. Diabetes Res Clin Pract 147:166–168
Bernardini S, Tiezzi A, Laghezza Masci V, Ovidi E (2018) Natural products for human health: an historical overview of the drug discovery approaches. Nat Prod Res 32:1926–1950
Caradus JR, Johnson LJ (2019) Improved adaptation of temperate grasses through mutualism with fungal endophytes. In: Schouten A (ed) Endophyte biotechnology: potential for agriculture and pharmacology, CABI biotechnology series. Wageningen University and Research Centre, Wageningen, p 85
Chandrakar S, Gupta AK (2018) Actinomycin-producing endophytic Streptomyces parvulus associated with root of Aloe vera and optimization of conditions for antibiotic production. Probiot Antimicrob 2018:1–15
Chen Y, Shafi J, Li M, Fu D, Ji M (2018) Insecticidal activity of endophytic actinomycetes isolated from Azadirachta indica against Myzus persicae. Arch Biol Sci 70:349–357
Chigurupati S, Vijayabalan S, Selvarajan KK, Aldubayan M, Alhowail A, Mani V, Das S (2020) Antimicrobial exploration between counterpart endosymbiont and host plant (Tamarindus indica Linn.). Curr Pharm Biotechnol 21:384–389
Dalee AD, Mukhurah S, Sali K, Hayeeyusoh N, Hajiwangoh Z, Salaeh P (2015) Antimicrobial substances from endophytic fungi in tamarind (Tamarindus indica, Linn), Malay apple (Eugenia malaccensis, Linn), rambutan (Nephelium lappaceum), and Indian mulberry (Morindacitrifolia, Linn). In: Abstracts of the international conference on research, implementation and education of mathematics and sciences, Yogyakarta State University, 17–19 May 2015
Das R, Romi W, Das R, Sharma HK, Thakur D (2018) Antimicrobial potentiality of actinobacteria isolated from two microbiologically unexplored forest ecosystems of Northeast India. BMC Microbiol 18:71
De Silva NI, Brooks S, Lumyong S, Hyde KD (2019) Use of endophytes as biocontrol agents. Fungal Biol Rev 33:133–148
Dureja H, Kaushik D, Kumar V (2003) Developments in nutraceuticals. Indian J Pharmacol 35:363–372
Ebrahim W, Ebada SS, Proksch P (2019) Bioprospecting of endophytes. In: Schouten A (ed) Endophyte biotechnology: potential for agriculture and pharmacology, CABI biotechnology series. Wageningen University and Research Centre, Wageningen, pp 145–163
Eid AM, Salim SS, Hassan SE-D, Ismail MA, Fouda A (2019) Role of endophytes in plant health and abiotic stress management. In: Microbiome in plant health and disease. Springer, Singapore, pp 119–144
Fazil M, Akram M (2019) Factors contributing to irritability in diabetes mellitus type-2 patients. Alternat Integr Med 8:277
Fazil M, Nikhat S (2019) Nutraceutical and pharmacological appraisal of Amla (Emblica officinalis Gaertn.): a review. Eur J Med Chem 30:1–13
Gangwar M, Dogra S, Gupta UP, Kharwar RN (2014) Diversity and biopotential of endophytic actinomycetes from three medicinal plants in India. Afr J Microbiol Res 8:184–191
Gangwar M, Kaur N, Saini P, Kalia A (2015) The diversity, plant growth promoting and anti-microbial activities of endophytic actinomycetes isolated from Emblica officinalis Gaertn. Int J Adv Res 3:1062–1071
Ghosh S, Chatterjee D, Das S, Bhattacharjee P (2013) Supercritical carbon dioxide extraction of eugenol-rich fraction from Ocimum sanctum Linn and a comparative evaluation with other extraction techniques: process optimization and phytochemical characterization. Ind Crop Prod 47:78–85
Godinez-Oviedo A, Guemes-Vera N, Acevedo-Sandoval O (2016) Nutritional and phytochemical composition of Moringa oleifera Lam and its potential use as nutraceutical plant: a review. PJN 15:397–405
Gohain A et al (2015) Antimicrobial biosynthetic potential and genetic diversity of endophytic actinomycetes associated with medicinal plants. FEMS Microbiol Lett 362:fnv158
Gohain A, Sarma RK, Debnath R, Saikia J, Singh BP, Sarmah R, Saikia R (2019) Phylogenetic affiliation and antimicrobial effects of endophytic actinobacteria associated with medicinal plants: prevalence of polyketide synthase type II in antimicrobial strains. Folia Microbiol 64:481–496
Goothy SSK, Goothy S, Choudhary A, Potey G, Chakraborty H, Kumar AH, Mahadik V (2020) Ayurveda’s holistic lifestyle approach for the management of coronavirus disease (COVID-19): possible role of tulsi. Int J Res Pharm Sci 11:16–18
Gowda M, Sheetal A, Kole C (eds) (2019) The neem genome. Springer International Publishing, Cham, pp 21–30
Guilmoto C, Oliveau S (2018) Population distribution across Asia. In: Routledge handbook of Asian demography. Routledge, Abingdon, pp 268–284
Haq F, Ahmad H, Alam M (2011) Traditional uses of medicinal plants of Nandiar Khuwarr catchment (District Battagram), Pakistan. J Med Plant Res 5:39–48
Hasan MR, Islam MN, Islam MR (2016) Phytochemistry, pharmacological activities and traditional uses of Emblica officinalis: a review. Int Curr Pharm J 5:14–21
Husain SZ, Malik RN, Javaid M, Bibi S (2008) Ethonobotanical properties and uses of medicinal plants of Morgah biodiversity park, Rawalpindi. Pak J Bot 40:1897–1911
Hussain K, Majeed MT, Ismail Z, Sadikun A, Ibrahim P (2009) Traditional and complementary medicines: quality assessment strategies and safe usage. South Med Rev 2:19–23
Jain M, Shrivastava PN, Samar R (2018) Survey of ethnobotanical medicinal plants used by the people of district Guna, Madhya Pradesh, India. Int J Life Sci Sci Res 2455:1716
Jones CG, Lawton JH, Shachak M (1994) Organisms as ecosystem engineers. In: Ecosystem management. Springer, New York, pp 130–147
Joseph B, Priya RM (2011) Bioactive compounds from endophytes and their potential. Am J Biochem Mol Biol 1:291–309
Joshi KK, Joshi SD (2001) Genetic heritage of medicinal and aromatic plants of Nepal Himalayas. Buddha Academic Publishers, Kathmandu, p 255
Joshi S, Singh AV, Prasad B (2018) Enzymatic activity and plant growth promoting potential of endophytic bacteria isolated from Ocimum sanctum and Aloe vera. Int J Curr Microbiol Appl Sci 7:2314–2326
Kaur N, Arora DS, Kalia N, Kaur M (2020) Antibiofilm, antiproliferative, antioxidant and antimutagenic activities of an endophytic fungus Aspergillus fumigatus from Moringa oleifera. Mol Biol Rep 47:2901–2911
Kumar RR, Jadeja VJ (2016) Endophytic actinomycetes: a novel antibiotic source. Int J Curr Microbiol Appl Sci 5:164–175
Kuncharoen N, Kudo T, Ohkuma M, Tanasupawat S (2019) Micromonospora azadirachtae sp. nov., isolated from roots of Azadirachta indica A. Juss. var. siamensis Valeton. Ant Leeuw 112:253–262
Maity P, Biswas K, Chattopadhyay I, Banerjee RK, Bandyopadhyay U (2009) The use of neem for controlling gastric hyperacidity and ulcer. Phytother Res 23:747–755
Masand M, Jose PA, Menghani E, Jebakumar SRD (2015) Continuing hunt for endophytic actinomycetes as a source of novel biologically active metabolites. World J Microbiol Biotechnol 31:1863–1875
Mohan L, Amberkar M, Kumari M (2011) Ocimum sanctum Linn (Tulsi)—an overview. Int J Pharm Sci Rev Res 7:51–53
Mosquera WG, Criado LY, Guerra BE (2020) Actividad antimicrobiana de hongos endófitos de las plantas medicinales Mammea americana (Calophyllaceae) y Moringa oleifera (Moringaceae). Biomédica 40:55–71
Mukherjee PK, Kumar V, Kumar NS, Heinrich M (2008) The Ayurvedic medicine Clitoria ternatea—from traditional use to scientific assessment. J Ethnopharmacol 120:291–301
Mushtaq S, Abbasi BH, Uzair B, Abbasi R (2018) Natural products as reservoirs of novel therapeutic agents. EXCLI J 17:420–451
Nakatsuka N et al (2017) The promise of discovering population-specific disease-associated genes in South Asia. Nat Genet 49:1403–1407
Nath A, Raghunatha P, Joshi S (2012) Diversity and biological activities of endophytic fungi of Emblica officinalis, an ethnomedicinal plant of India. Mycobiology 40:8–13
Nawaz F, Tanvir R, Nawaz M, Javeed A, Sajid I (2018) The effects of polar and non polar compounds from endophytic actinomycetes in Ocmium tenuiflorum (Tulsi) and Azadirachta indica (Neem) on veterinary and human pathogens. In: MDPI AG in 4th international electronic conference on medicinal chemistry session (ECMC-4). https://doi.org/10.3390/ecmc-4-05567
Pandey A, Pradheep K, Gupta R, Nayar ER, Bhandari D (2011) ‘Drumstick tree’ (Moringa oleifera Lam.): a multipurpose potential species in India. Genet Resour Crop Evol 58:453–460
Pandey M, Rastogi S, Rawat A (2013) Indian traditional Ayurveda system of medicine and nutritional supplementation. Evid Based Complement Alternat Med 2013:1–12
Parveen A, Parveen R, Akhatar A, Parveen B, Siddiqui KM, Iqbal M (2019) Concepts and quality considerations in Unani system of medicine. J AOAC Int. https://doi.org/10.5740/jaoacint.19-0284
Patwardhan B, Vaidya AD, Chorghade M (2004) Ayurveda and natural products drug discovery. Curr Sci 86:789–799
Prakash P, Gupta N (2005) Therapeutic uses of Ocimum sanctum Linn (Tulsi) with a note on eugenol and its pharmacological actions: a short review. Indian J Physiol Pharmacol 49:125
Prasher B, Gibson G, Mukerji M (2016) Genomic insights into Ayurveda and western approaches to personalized medicine. J Genet 95:209–228
Priya FF, Islam MS (2019) Phyllanthus emblica Linn. (Amla)—a natural gift to humans: an overview. JDMP 5:1–9
Priyadarsini RV, Manikandan P, Kumar GH, Nagini S (2009) The neem limonoids azadirachtin and nimbolide inhibit hamster cheek pouch carcinogenesis by modulating xenobiotic-metabolizing enzymes, DNA damage, antioxidants, invasion and angiogenesis. Free Radic Res 43:492–504
Radu S, Kqueen CY (2002) Preliminary screening of endophytic fungi from medicinal plants in Malaysia for antimicrobial and antitumor activity. MJMS 9:23–33
Rahal A, Kumar D, Malik JK (2019) Neem extract. In: Nutraceuticals in veterinary medicine. Springer, Cham, pp 37–50
Rathod D, Dar M, Gade A, Rai M (2014) Griseofulvin producing endophytic Nigrospora oryzae from Indian Emblica officinalis Gaertn: a new report. Aust J Biotechnol Bioeng 1:5
Rupani R, Chavez A (2018) Medicinal plants with traditional use: ethnobotany in the Indian subcontinent. Clin Dermatol 36:306–309
Saini P, Gangwar M, Kalia A, Singh N, Narang D (2016) Isolation of endophytic actinomycetes from Syzygium cumini and their antimicrobial activity against human pathogens. J Appl Nat Sci 8:416–422
Sen S, Chakraborty R (2017) Revival, modernization and integration of Indian traditional herbal medicine in clinical practice: importance, challenges and future. J Tradit Complement Med 7:234–244
Shah S, Patil S (2019) Standardization of Tulsi Taila: an ayurvedic oil based medicine. J Drug Deliv Ther 9:699–702
Sharma V, Saksena K (1959) ‘Sodium-nimbidinate’—in vitro study of its spermicidal action. Indian J Med Sci 13:1038
Shinde N, Bangar B, Deshmukh S, Kumbhar P (2014) Nutraceuticals: a review on current status. Res J Pharm Technol 7:110–113
Shinwari ZK, Qaiser M (2011) Efforts on conservation and sustainable use of medicinal plants of Pakistan. Pak J Bot 43:5–10
Singh MJ, Padmavathy S (2014) Comparative screening of enzyme producing endophytic actinomycetes from fresh and fallen leaves of Emblica officinalis in Western Ghats. Int J Biol Res 2(2):129–130
Singh MJ, Padmavathy S (2015) Nocardiopsis sp. 5 endophytic to tulsi leaves-isolation and antimicrobial activity. Br Microbiol 5:194–202
Singh AK, Rana HK, Tshabalala T, Kumar R, Gupta A, Ndhlala AR, Pandey AK (2019) Phytochemical, nutraceutical and pharmacological attributes of a functional crop Moringa oleifera Lam: an overview. S Afr J Bot. https://doi.org/10.1016/j.sajb.2019.06.017
Sivareddy B, Reginald BA, Sireesha D, Samatha M, Reddy KH, Subrahamanyam G (2019) Antifungal activity of solvent extracts of Piper betle and Ocimum sanctum Linn on Candida albicans: an in vitro comparative study. JOMFP 23:333
Soni N, Singh VK (2019) Traditional, nutraceutical and pharmacological approaches of Tamarindus indica (Imli). Eur J Biol Res 9:141–154
Srivastava AK (2018) Significance of medicinal plants in human life. In: Synthesis of medicinal agents from plants. Elsevier, Amsterdam, pp 1–24
Subapriya R, Nagini S (2005) Medicinal properties of neem leaves: a review. Anti Cancer Agents Med Chem 5:149–156
Sundarrajan S, Arumugam M (2017) Documentation of traditional Siddha medicines for skin diseases from Katpadi taluk, Vellore District, Tamil Nadu, India. Eur J Integr Med 9:52–62
Surkar A, Lavania S, Pandey D, Pant M (1994) Changes in the blood lipid profile after administration of Ocimum sanctum (Tulsi) leaves in the normal albino rabbits. Indian J Physiol Pharmacol 38:311–311
Taechowisan T, Peberdy JF, Lumyong S (2003) Isolation of endophytic actinomycetes from selected plants and their antifungal activity. World J Microbiol Biotechnol 19:381–385
Tandale A, Khandagale M, Palaskar R, Kulkarni S (2018) Isolation of pigment producing actinomycetes from soil and screening their antibacterial activities against different microbial isolates. Int J Curr Res Life Sci 7:2397–2402
Tanvir R, Sheikh AA, Javeed A (2020) Endophytic actinomycetes in Indo-Pak medicinal plants leading to new trends in drug discovery. In: Muhammad Hatha AA (ed) A closer look at actinomycetes. Nova Science Publishers, New York, pp 41–80
Variya BC, Bakrania AK, Patel SS (2016) Emblica officinalis (Amla): a review for its phytochemistry, ethnomedicinal uses and medicinal potentials with respect to molecular mechanisms. Pharmacol Res 111:180–200
Verma VC, Gond SK, Kumar A, Mishra A, Kharwar RN, Gange AC (2009) Endophytic actinomycetes from Azadirachta indica A. Juss.: isolation, diversity, and anti-microbial activity. Microb Ecol 57:749–756
Walter C, Shinwari ZK, Afzal I, Malik RN (2011) Antibacterial activity in herbal products used in Pakistan. Pak J Bot 43:155–162
Wangchuk P, Samten U, Thinley J, Afaq S (2008) High altitude plants used in Bhutanese traditional medicine (g. so-ba-rig-pa). Ethnobotany 20:54–64
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Ilyas, A., Tanvir, R., Rehman, Y. (2021). Indo-Pak Medicinal Plants and Their Endophytes: An Emphasis on Nutraceutical and Bioactive Potential. In: Patil, R.H., Maheshwari, V.L. (eds) Endophytes. Springer, Singapore. https://doi.org/10.1007/978-981-15-9371-0_4
Download citation
DOI: https://doi.org/10.1007/978-981-15-9371-0_4
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-15-9370-3
Online ISBN: 978-981-15-9371-0
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)