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Advances in Mechanical Processing and Design pp 413–419Cite as

Interaction of Ru-4′-(2-pyridyl)- 2,2′:6′,2″-Terpyridine with Diseased HER2 Protein

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Part of the book series: Lecture Notes in Mechanical Engineering ((LNME))

Abstract

The development of new approaches to improve screening, diagnosis, prevention and treatment of cancer is an area of intensive research. Breast cancer is one such widespread category of cancer among women which is the world’s second leading cause of cancer death universally. The objective of this study is to analyze the structural stability of different diseased mutants of HER2 protein as well as to find out the inhibitory effects of Ru-terpyridine over mutant HER2 protein. To accomplish the study insight, we have carried out using different computational tools. From our in silico study, we conclude that, after mutation at positions D769H and V777L in HER2 protein, it was proceeded to cancerous growth and it becomes destabilize, followed by the binding performance of the ruthenium terpyridine over mutant HER2 protein shows the inhibitory effect against HER2 protein-targeted breast cancer.

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Author information

Authors and Affiliations

  1. School of Applied Sciences, Kalinga Institute of Industrial Technology (KIIT), Deemed to be University, Bhubaneswar, Odisha, 751024, India

    Satya Narayan Sahu, Tejaswini Sahoo, Biswajit Mishra & Rojalin Sahu

  2. Department of Chemistry, National Institute of Technology Raipur, Raipur, 492010, India

    Subrat Kumar Pattanayak

Authors
  1. Satya Narayan Sahu
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  2. Tejaswini Sahoo
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  3. Biswajit Mishra
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  4. Subrat Kumar Pattanayak
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  5. Rojalin Sahu
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Corresponding authors

Correspondence to Subrat Kumar Pattanayak or Rojalin Sahu .

Editor information

Editors and Affiliations

  1. Department of Metallurgical Engineering and Materials Science, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India

    Prita Pant

  2. Department of Mechanical Engineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India

    Sushil K. Mishra

  3. School of Mechanical Engineering, KIIT Deemed to be University, Bhubaneswar, Odisha, India

    Purna Chandra Mishra

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Sahu, S.N., Sahoo, T., Mishra, B., Pattanayak, S.K., Sahu, R. (2021). Interaction of Ru-4′-(2-pyridyl)- 2,2′:6′,2″-Terpyridine with Diseased HER2 Protein. In: Pant, P., Mishra, S.K., Mishra, P.C. (eds) Advances in Mechanical Processing and Design. Lecture Notes in Mechanical Engineering. Springer, Singapore. https://doi.org/10.1007/978-981-15-7779-6_35

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  • DOI: https://doi.org/10.1007/978-981-15-7779-6_35

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-15-7778-9

  • Online ISBN: 978-981-15-7779-6

  • eBook Packages: EngineeringEngineering (R0)

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