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The Association of Gut Microbiota and Treg Dysfunction in Autoimmune Diseases

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Book cover T Regulatory Cells in Human Health and Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1278))

Abstract

Autoimmune conditions affect 23 million Americans or 7% of the US population. There are more than 100 autoimmune disorders, affecting every major organ system in humans. This chapter aims to further explain Treg dysfunction autoimmune disorders, including monogenic primary immune deficiency such as immune dysregulation polyendocrinopathy, enteropathy, X-linked inheritance (IPEX) syndrome, and polygenic autoimmune diseases with Treg dysfunction such as multiple sclerosis (MS), inflammatory bowel disease (IBD), and food allergy. These conditions are associated with an abnormal small intestinal and colonic microbiome. Some disorders clearly improve with therapies aimed at microbial modification, including probiotics and fecal microbiota transplantation (FMT). Approaches to prevent and treat these disorders will need to focus on the acquisition and maintenance of a healthy colonic microbiota, in addition to more focused approaches at immune suppression during acute disease exacerbations.

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Authors and Affiliations

  1. Department of Pediatrics, Division of Gastroenterology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, USA

    Yuying Liu, Dat Q. Tran & Jon Marc Rhoads

  2. Department of Neurology, Division of Multiple Sclerosis and Neuroimmunology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, USA

    John William Lindsey

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  1. Yuying Liu
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  2. Dat Q. Tran
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  3. John William Lindsey
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  4. Jon Marc Rhoads
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Correspondence to Jon Marc Rhoads .

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Editors and Affiliations

  1. Department of Internal Medicine, Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH, USA

    Song-Guo Zheng

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Liu, Y., Tran, D.Q., Lindsey, J.W., Rhoads, J.M. (2021). The Association of Gut Microbiota and Treg Dysfunction in Autoimmune Diseases. In: Zheng, SG. (eds) T Regulatory Cells in Human Health and Diseases. Advances in Experimental Medicine and Biology, vol 1278. Springer, Singapore. https://doi.org/10.1007/978-981-15-6407-9_10

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