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Application of Nanomaterials for Cancer Diagnosis and Therapy

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Green Synthesis of Nanoparticles: Applications and Prospects

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Abstract

The extensive application of nanoparticles in diverse fields, ranging from agricultural, environmental, computational, and industrial sciences to pharmaceutical and biomedical sciences, is expected to revolutionize many aspects of human life. With the continuous development of nanotechnology, the medical application of nanomaterials has gained increasing interests from both academic and industrial communities. Various functionalized nanomaterials, such as molecular imaging biomarkers and biosensors, drug carriers, biological devices, and nanomedicine, are designed and developed for specific medical purposes. In this chapter, we will give a brief introduction to nanotechnology and nanomaterials and their biomedical applications in cancer diagnosis and therapy; summarize their unique properties for cancer diagnostic and therapeutic applications; enumerate representative functionalized nanomaterials developed for biomedical applications, in particular their advantages and disadvantages for applications in early cancer detection and diagnosis as well as therapeutic drug discovery and delivery; and discuss the challenges and prospects for future exploitations of these nanomaterials.

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Abbreviations

CNTs:

Carbon nanotubes

CT:

Computed tomography

EPR:

Enhanced permeability and retention

IONPs:

Iron oxide nanoparticles

MRI:

Magnetic resonance imaging

MSNs:

Mesoporous silica nanoparticles

MWCNT:

Multi-walled nanotubes

OI:

Optical imaging

PAMAM:

Poly(amidoamine)

PDT:

Photodynamic therapy

PEG:

Polyethylene glycol

PET:

Positron emission computed tomography

PLGA:

Poly(lactic-co-glycolic acid)

PTT:

Photothermal therapy

QDs:

Quantum dots

SPECT:

Single-photon emission computed tomography

SPIONPs:

Superparamagnetic iron oxide nanoparticles

SWCNT:

Single-walled nanotubes

US:

Ultrasonography

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Acknowledgments

Financial supports were provided by the National Natural Science Foundation of China (81901232, 81773620) and Shanghai Sailing Program (20YF1402800).

Author information

Author notes

  1. Shaofei Wang and Yubin Li contributed equally to this work.

Authors and Affiliations

  1. Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, People’s Republic of China

    Shaofei Wang

  2. Department of Neurology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, People’s Republic of China

    Yubin Li

  3. Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Yubin Li

  4. Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA

    Yubin Li

  5. Department of Biological Medicine and Shanghai Engineering Research Center of Immunotherapeutics, School of Pharmacy, Fudan University, Shanghai, People’s Republic of China

    Dianwen Ju

Authors
  1. Shaofei Wang
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  2. Yubin Li
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  3. Dianwen Ju
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Corresponding author

Correspondence to Dianwen Ju .

Editor information

Editors and Affiliations

  1. Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia

    Quaiser Saquib

  2. Department of Botany & Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia

    Mohammad Faisal

  3. Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia

    Abdulaziz A. Al-Khedhairy

  4. Department of Botany & Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia

    Abdulrahman A. Alatar

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Wang, S., Li, Y., Ju, D. (2020). Application of Nanomaterials for Cancer Diagnosis and Therapy. In: Saquib, Q., Faisal, M., Al-Khedhairy, A.A., Alatar, A.A. (eds) Green Synthesis of Nanoparticles: Applications and Prospects. Springer, Singapore. https://doi.org/10.1007/978-981-15-5179-6_6

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