Abstract
Neuropharmacology is a field that utilizes the knowledge about drugs, especially their mechanism of action to develop safe and effective medicines for the cure of a variety of neurological disorders. Increasing number of patients suffering from the diseases all over the world have accounted for billions of dollars in the healthcare industry. Thus the demand for effective medicines is increasing globally. Innovative methods are being explored for drug development as there is still no cure or any effective disease-modifying therapy because the existing drugs just aid in managing the symptoms of these diseases. With the help of advancing technology, efforts have been made to understand the molecular structure of receptors and neurotransmitters to synthesize target-specific drugs that would not produce any unwanted side effects. This review tries to discuss different approaches like omics technology, neural engineering, stem cells, gene therapy, and antiviral therapies for the successful understanding of pathology of disease that would lead to drugs that would be specific and free from any unwanted effects.
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Nestler EJ, Hyman SE, Malenka RC (2008) Molecular neuropharmacology: a foundation for clinical neuroscience, 2nd edn. McGraw-Hill, New York, USA
Wagner EH, Groves T (2002) Care for chronic diseases. BMJ 325:913–914
Wu J (2013) Today in psychopharmacology and neuropharmacology. Biochem Pharmacol S1:e001
Haggarty SJ, Perlis RH (2014) Translation: screening for novel therapeutics with disease-relevant cell types derived from human stem cell models. Biol Psychiatry 75:952–960
Farkhondeh A, Li R, Gorshkov K, Chen KG, Might M, Rodems S, Lo DC, Zheng W (2019a) Induced pluripotent stem cells for neural drug discovery. Drug Discov Today 24:992–999
Charney DS, Mihic SJ, Harris RA (2001) Hypnotics and sedatives. In: Hardman JG, Limbard LE (eds) Goodman and Gilman’s The Pharmacological Basis of Therapeutics, 10th edn. Mc Graw Hill, New York
Choong CJ, Baba K, Mochizuki H (2016) Gene therapy for neurological disorders. Exp Opin Biol Therapy 16:143–159
O’Connor DM, Boulis NM (2015) Gene therapy for neurodegenerative diseases. Trends Mol Med 21:504–512
Gowing G, Svendsen S, Svendsen CN (2017) Ex vivo gene therapy for the treatment of neurological disorders. Prog Brain Res 230:99–132
Savic N, Schwank G (2016) Advances in therapeutic CRISPR/Cas9 genome editing. Transl Res 168:15–21
Nanou A, Azzouz M (2009) Gene therapy for neurodegenerative diseases based on lentiviral vectors. Prog Brain Res 175:187–200
Weinberg MS, Samulski RJ, McCown TJ (2013) Adeno-associated virus (AAV) gene therapy for neurological disease. Neuropharmacology 69:82–88
Behrstock S, Ebert A, McHugh J, Vosberg S, Moore J, Schneider B, Capowski E, Hei D, Kordower J, Aebischer P, Svendsen CN (2006) Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates. Gene Ther 13:379–388
Klein SM, Behrstock S, McHugh J, Hoffmann K, Wallace K, Suzuki M, Aebischer P, Svendsen CN (2005) GDNF delivery using human neural progenitor cells in a rat model of ALS. Hum Gene Ther 16:509–521
Naldini L (2011) Ex vivo gene transfer and correction for cell-based therapies. Nat Rev Genet 12:301–315
Piguet F, Alves S, Cartier N (2017) Clinical gene therapy for neurodegenerative diseases: past, present, and future. Hum Gene Therapy 28:988–1003
Zhang J, Wu X, Qin C, Qi J, Ma S, Zhang H, Kong Q, Chen D, Ba D, He W (2003) A novel recombinant adeno-associated virus vaccine reduces behavioral impairment and beta-amyloid plaques in a mouse model of Alzheimer’s disease. Neurobiol Dis 14:365–379
Mouri A, Noda Y, Hara H, Mizoguchi H, Tabira T, Nabeshima T (2007) Oral vaccination with a viral vector containing Abeta cDNA attenuates agerelated Abeta accumulation and memory deficits without causing inflammation in a mouse Alzheimer model. FASEB J 21:2135–2148
Eberling JL, Jagust WJ, Christine CW, Starr P, Larson P, Bankiewicz KS, Aminoff MJ (2008) Results from a phase I safety trial of hAADC gene therapy for Parkinson disease. Neurology 70:1980–1983
Christine CW, Starr PA, Larson PS, Eberling JL, Jagust WJ, Hawkins RA, VanBrocklin HF, Wright JF, Bankiewicz KS, Aminoff MJ (2009) Safety and tolerability of putaminal AADC gene therapy for Parkinson disease. Neurology 73:1662–1669
Muramatsu S, Fujimoto K, Kato S, Mizukami H, Asari S, Ikeguchi K, Kawakami T, Urabe M, Kume A, Sato T, Watanabe E, Ozawa K, Nakano I (2010) A phase I study of aromatic l-amino acid decarboxylase gene therapy for Parkinson’s disease. Mol Ther 18:1731–1735
Mittermeyer G, Christine CW, Rosenbluth KH, Baker SL, Starr P, Larson P, Kalpan PL, Forsayeth J, Aminoff MJ, Bankiewicz KS (2012) Long-term evaluation of a phase 1 study of AADC gene therapy for Parkinson’s disease. Hum Gene Ther 23:377–381
Wang YL, Liu W, Wada E, Murata M, Wada K, Kanazawa I (2005) Clinico-pathological rescue of a model mouse of Huntington’s disease by siRNA. Neurosci Res 53:241–249
Thomsen GM, Gowing G, Latter J, Chen M, Vit JP, Staggenborg K, Avalos P, Alkaslasi M, Ferraiuolo L, Likhite S, Kaspar BK, Svendsen CN (2014) Delayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after suppression of mutant SOD1 in the motor cortex. J Neurosci 34:15587–15600
Xu DG, Crocker SJ, Doucet JP (1997) Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus. Nat Med 3:997–1004
Johnson RT (1995) Neurovirology: evolution of a new discipline. J Neuro-Oncol 1:2–4
Goodpasture EW (1929) Herpetic infection, with especial reference to involvement of the nervous system. Medicine 8:223–243
Oldstone MBA, Rall GF (1993) Mechanism and consequence of viral persistence in cells of the immune system and neurons. Infervirology 35:116–121
Haubenberger D, Clifford DB (2016) Clinical trials in neurovirology: successes, challenges and pitfalls. Neurotherapeutics 13:571–581
Califf RM, Sugarman J (2015) Exploring the ethical and regulatory issues in pragmatic clinical trials. Clin Trials 12:436–441
Proschan MA, Dodd LE, Price D (2016) Statistical considerations for a trial of Ebola virus disease therapeutics. Clin Trials 13:39–48
Berry SM, Petzold EA, Dull P, Thielman NM, Cunningham CK, Corey GR, McClain MT, Hoover DL, Russell J, Griffiss JM, Woods CW (2016) A response adaptive randomization platform trial for efficient evaluation of Ebola virus treatments: a model for pandemic response. Clin Trials 13:22–30
Duan N, Kravitz RL, Schmid CH (2013) Single-patient (n-of-1) trials: a pragmatic clinical decision methodology for patient-centered comparative effectiveness research. J Clin Epidemiol 66:21–28
U.S. National Library of Medicine (2019a) Dexamethasone in Herpes Simplex Virus Encephalitis (DexEnceph). https://clinicaltrials.gov/ct2/show/NCT03084783. Accessed 31 Aug 2019
U.S. National Library of Medicine (2019b) Long Term Treatment of Herpes Simplex Encephalitis (HSE) with Valacyclovir. https://clinicaltrials.gov/ct2/show/NCT00031486. Accessed 31 Aug 2019
U.S. National Library of Medicine (2019c) Intranasal Treatment of HIV-associated Neurocognitive Disorders. https://clinicaltrials.gov/ct2/show/NCT03277222. Accessed 31 Aug 2019
U.S. National Library of Medicine (2019d) Early Intensification of Antiretroviral Therapy Including Enfuvirtide in HIV-1-Related Progressive Multifocal Leucoencephalopathy. https://clinicaltrials.gov/ct2/show/NCT00120367?term=Progressive+Multifocal+Leukoencephalopathy&rank=6. Accessed 31 Aug 2019
Shi Y, Innoue H, Wu JC, Yamanaka S (2017) Induced pluripotent stem cell technology: a decade of progress. Nat Rev Drug Discov 16:115–130
Xu M, Motabar O, Ferrer M, Marugan JJ, Zheng W, Ottinger EA (2016) Disease models for the development of therapies for lysosomal storage diseases. Ann N Y Acad Sci 1371:15–29
Lindvall O, Kokia Z, Martinez-Serrano A (2004) Stem cell therapy for human neurodegenerative disorders-how to make it work. Nat Med 10:42–50
Lindvall O, Kokaia Z (2006) Stem cells for the treatment of neurological disorders. Nature 441:1094–1096
Mattis VB et al (2012) Induced pluripotent stem cells from patients with Huntington’s disease show CAG-repeat-expansion-associated phenotypes. Cell Stem Cell 11:264–278
Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663–676
Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131:861–872
Adegbola A et al (2017) Concise review: induced pluripotent stem cell models for neuropsychiatric diseases. Stem Cells Transl Med 6:2062–2070
Kondo T et al (2013) Modeling Alzheimer’s disease with iPSCs reveals stress phenotypes associated with intracellular Abeta and differential drug responsiveness. Cell Stem Cell 12:487–496
Imaizumi Y, Okano H (2014) Modeling human neurological disorders with induced pluripotent stem cells. J Neurochem I 29:388–399
Raab S, Klingenstein M, Liebau S, Linta L (2014) A comparative view on human somatic cell sources for iPSC generation. Stem Cells Int 2014:768391
Soliman MA, Aboharb F, Zeltner N, Studer L (2017) Pluripotent stem cells in neuropsychiatric disorders. Mol Psychiatry 22:1241–1249
Sun W, Zheng W, Simeonov A (2017) Drug discovery and development for rare genetic disorders. Am J Med Genet A 173:2307–2322
Farkhondeh A, Li R, Gorshkov K, Chen KG, Might M, Rodems S, Lo DC, Zheng W (2019b) Induced pleuripotent stem cells for neural drug discovery. Drug Discov Today 24:992–999
Debnath M, Prasad GBKS, Bisen PS (2010) Molecular diagnostics: promises and possibilities. Springer Dordrecht Heidelberg, London
Crowther LM, Poms M, Plecko B (2018) Multiomics tools for the diagnosis and treatment of rare neurological disease. J Inherit Metab Dis 41:425–434
Abela L, Simmons L, Steindl K et al (2016) N (8)-acetylspermidine as a potential plasma biomarker for Snyder-Robinson syndrome identified by clinical metabolomics. J Inherit Metab Dis 39:131–137
Abela L, Spiegel R, Crowther LM et al (2017) Plasma metabolomics reveals a diagnostic metabolic fingerprint for mitochondrial aconitase (ACO2) deficiency. PLoS One 12:e0176363
Sirrs S, van Karnebeek CD, Peng X et al (2015) Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms. Orphanet J Rare Dis 10:38
Tarailo-Graovac M, Shyr C, Ross CJ et al (2016) Exome sequencing and the management of neurometabolic disorders. N Engl J Med 374:2246–2255
Durand DM (2007) What is neural engineering? J Neural Eng 4:4
Mitrasinovic S, Brown APY, Schaefer AT, Steven DC, Appelboom G (2018) Silicon valley new focus on brain computer interface: hype or hope for new applications? F1000 Res 7:1327
Hochberg LR, Bacher D, Jarosiewicz B et al (2012) Reach and grasp by people with tetraplegia using a neurally controlled robotic arm. Nature 485:372–375
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Siju, E.N., Rajalakshmi, G.R. (2020). Neuropharmacology: Looking Forward to the Future. In: Mathew, B., Thomas Parambi, D.G. (eds) Principles of Neurochemistry. Springer, Singapore. https://doi.org/10.1007/978-981-15-5167-3_10
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DOI: https://doi.org/10.1007/978-981-15-5167-3_10
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