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Dendrimer-Based Tumor-targeted Systems

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New Nanomaterials and Techniques for Tumor-targeted Systems

Abstract

Dendrimers have a unique three-dimensional structure, highly branched macromolecular features, and abundant terminal functional groups. These features of dendrimers support their uses as universal nanoplatforms to prepare multifunctional nanodevices for a myriad of biomedical applications, particularly for targeted imaging and therapy of different biosystems. The periphery of the dendrimer enables the attachment of targeting ligands and imaging agents, while the internal cavity allows the embedment of metal nanoparticles (NPs), anticancer drugs, and other inorganic NPs. Meanwhile, the versatile dendrimer nanotechnology enables different types of integration with varied inorganic components. The resulting hybrid dendrimer-based particles are useful in a variety of imaging, therapy, or theranostic applications. This chapter focuses on the latest advances in the dendrimer-based targeting systems for the imaging, therapy, and theranostics of cancer.

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Abbreviations

3D:

3-dimensional

99mTc:

Technetium-99m

α-TOS:

α-tocopheryl succinate

AuNPs:

Gold nanoparticles

AFM:

Atomic force microscopy

Au DENPs-FA:

Folic acid-modified dendrimer-entrapped gold nanoparticles

ASGPR:

Asialoglycoprotein receptors

BBB:

Blood brain barrier

bis-MPA:

2,2-bis(hydroxymethyl)propionic acid

CT:

Computer tomography

DOTA:

Tetraazacyclododecane-1,4,7,10-tetraacetic acid

DOTA-NHS:

(2,2′,2′′-(10-(2-(2,5-dioxopyrrolidin-1-yloxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl) triacetic acid

DTPA:

Diethylenetriaminepentaacetic acid

DENPs/DSNPs:

Dendrimer-entrapped nanoparticles/dendrimer-stabilized nanoparticles

DOX:

Doxorubicin

EPR:

Enhanced permeability and retention

EGFP:

Enhanced green fluorescent protein

FA:

Folic acid

FAR:

FA receptors

FA-PEG-COOH:

PEG-modified FA with carboxyl end group

FI:

Fluorescein isothiocyanate

FDG:

2-18F-fluoro-2-deoxy-D-glucose

FAM:

Fluorescein amidite

FPP:

FA-PEG-PAMAM

Gd-Au DENPs:

Gd-loaded Au DENPs

G:

Generation

Gal:

Galactose

HA:

Hyaluronic acid

HPAO:

3-(4’-hydroxyphenyl) propionic acid-OSu

hMSCs:

Human mesenchymal stem cells

HER2:

Human epidermal growth factor receptor-2

HEGFR:

Human epidermal growth factor receptor

HCC:

Hepatocellular carcinoma

HUVEC:

Human umbilical vein endothelial cells

IO:

Iron oxide

IL-6:

Interleukin-6

LA:

Lactobionic acid

LA-Au DENPs:

LA-modified dendrimer-entrapped gold nanoparticles

Luc:

Luciferase

MR:

Magnetic resonance

MWCNTs:

Multi-walled carbon nanotubes

mPEG-COOH:

PEG monomethyl ether with carboxyl end group

NCPs:

Nanocomposite particles

PEG:

Polyethylene glycol

NAcGal:

N-acetylgalactosamine

PAMAM:

Poly(amidoamine)

PLL:

Poly(l-lysine)

PPI:

poly(propyleneimine)

PSMA:

Prostate specific membrane antigen

PET:

Positron emission computed tomography

PGA:

Poly(γ-glutamic acid)

QDs:

Quantum dots

RGD:

Arg-Gly-Asp

RGD-4C:

Cyclized RGD

RT:

Radiotherapy

SPECT:

Single-photon emission computed tomography

SMVT:

Sodium-dependent multivitamin transporter

US:

Ultrasound

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Acknowledgments

This research is financially supported by the Shanghai Leading Talents Program, National Natural Science Foundation of China (21773026 and 81761148028), the Science and Technology Commission of Shanghai Municipality (17540712000, 19XD1400100, 19410740200 and 18520750400), and the 111 project (BP0719035).

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  1. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, International Joint Laboratory for Advanced Fiber and Low-dimension Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, People’s Republic of China

    Zhijun Ouyang, Du Li, Mingwu Shen & Xiangyang Shi

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  1. Zhijun Ouyang
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  2. Du Li
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  3. Mingwu Shen
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  4. Xiangyang Shi
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Correspondence to Xiangyang Shi .

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  1. Department of Pharmaceutics, School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, Shanghai, China

    Rongqin Huang

  2. Center for Advanced Low-dimension Materials, Donghua University, Shanghai, China

    Yi Wang

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Ouyang, Z., Li, D., Shen, M., Shi, X. (2020). Dendrimer-Based Tumor-targeted Systems. In: Huang, R., Wang, Y. (eds) New Nanomaterials and Techniques for Tumor-targeted Systems. Springer, Singapore. https://doi.org/10.1007/978-981-15-5159-8_10

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