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Benzo(a)Pyrene Induced ROS-Mediated Lung Cancer

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Handbook of Oxidative Stress in Cancer: Mechanistic Aspects

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Abstract

Lung cancer is the world’s second-largest cause of death from cancer. Cigarette smoking is identified as one of the single, well-known risk factors for lung cancer of all types. A potent carcinogen in cigarette smoke is benzo(a)pyrene (B[a]P). Its reactive metabolite, which can cause mutations, induces DNA adducts. In the respiratory system, reactive oxygen (ROS) and oxidative stress increase the production of pulmonary inflammatory mediators and activate or facilitate carcinogenic mechanisms. Recent epidemiological studies have demonstrated correlations between increased incidence of respiratory diseases and lung cancer from benzo(a)pyrene exposure. This chapter summarizes how benzo(a)pyrene induces lung cancer through oxidative stress.

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Author notes

  1. Rebai Ben Ammar and Peramaiyan Rajendran contributed equally with all other contributors.

Authors and Affiliations

  1. Department of Biological Sciences, College of Science, King Faisal University, Al Ahsa, Saudi Arabia

    Rebai Ben Ammar, Emad A. Ahmed & Peramaiyan Rajendran

  2. Laboratory of Aromatic and Medicinal Plants, Center of Biotechnology, Technopole of Borj-Cedria, Hammam-Lif, Tunisia

    Rebai Ben Ammar

  3. Department of Nuclear Medicine, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait

    Fatma J. Al Saeedi

Authors
  1. Rebai Ben Ammar
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  2. Fatma J. Al Saeedi
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  3. Emad A. Ahmed
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  4. Peramaiyan Rajendran
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Corresponding author

Correspondence to Peramaiyan Rajendran .

Editor information

Editors and Affiliations

  1. Department of Biochemistry and Biophysic, University of Kalyani Department of Biochemistry and Biophysic, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Dept of Veterinary Pathobiology, University of Missouri, College Vet, Columbia, MO, USA

    Bimal K Ray

  3. Saroj Gupta Cancer Centre & Research Ins, Kolkata, India

    Sushanta Roychowdhury

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Ammar, R.B., Al Saeedi, F.J., Ahmed, E.A., Rajendran, P. (2021). Benzo(a)Pyrene Induced ROS-Mediated Lung Cancer. In: Chakraborti, S., Ray, B.K., Roychowdhury, S. (eds) Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-15-4501-6_37-1

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  • DOI: https://doi.org/10.1007/978-981-15-4501-6_37-1

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-15-4501-6

  • Online ISBN: 978-981-15-4501-6

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