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Pharmacology of Neuropeptides: Substance P, Vasoactive Intestinal Peptides, Neuropeptide Y, Calcitonin Peptides and Their Receptors

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Abstract

Neuropeptides are responsible for the regulation of various biological activities and mediate various regulatory mechanisms associated with every organ system. They control and regulate communication between endocrine and nervous systems and are also involved in signaling between cells found in the central and peripheral nervous system. Certainly, they can modulate immunomodulation, neuroprotection, and physiological homeostasis (e.g., feeding behavior, balance of water, blood pressure, breakdown of glucose, cognition, stress response, and pain) by working as peptide hormones.

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Abbreviations

CD:

Circular dichroism

CNS:

Central nervous system

DAG:

Diacylglycerol

GDP:

Guanosine diphosphate

GLP:

Glucagon-like peptide

GPCRs:

G protein-coupled receptors

GTP:

Guanosine triphosphate

IL:

Interleukin

IP3:

Inositol triphosphate

NF-κB:

Nuclear factor kappa B

NK1R:

Neurokinin one receptor

NK2R:

Neurokinin two receptor

NK3R:

Neurokinin three receptor

NKA:

Neurokinin A

NKB:

Neurokinin B

NMR:

Nuclear magnetic resonance

PACAP:

Pituitary adenylate cyclase activity peptide

PHI:

Peptide histidine isoleucine

PRL:

Pituitary prolactin

SP:

Substance P

TAC :

Tachykinin

TNF:

Tumor necrosis factor

VIP:

Vasoactive intestinal polypeptide

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Authors and Affiliations

  1. Faculty of Pharmacy, Philadelphia University, Amman, Jordan

    Nabil A. Nimer, Najlaa S. Ismael, Ruwaida W. Abdo, Sura Y. Taha Alkhammas & Qutaiba A. Alkhames Aga

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  1. Nabil A. Nimer
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  2. Najlaa S. Ismael
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  3. Ruwaida W. Abdo
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  1. Department of Pharmacology, Central University of Punjab, Bathinda, Punjab, India

    Puneet Kumar

  2. Department of Pharmaceutical Sciences Faculty of Pharmacy, Philadelphia University, Amman, Jordan

    Pran Kishore Deb

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Nimer, N.A., Ismael, N.S., Abdo, R.W., Taha Alkhammas, S.Y., Alkhames Aga, Q.A. (2020). Pharmacology of Neuropeptides: Substance P, Vasoactive Intestinal Peptides, Neuropeptide Y, Calcitonin Peptides and Their Receptors. In: Kumar, P., Deb, P.K. (eds) Frontiers in Pharmacology of Neurotransmitters. Springer, Singapore. https://doi.org/10.1007/978-981-15-3556-7_15

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