Abstract
Disease classification based on biological data is an important area in bioinformatics and biomedical research. It helps the doctors and medical practitioners for the early detection of disease and support them as a computer-aided diagnostic tool for accurate diagnosis, prognosis, and treatment of disease. Earlier Microarray gene expression data have wide application for the classification of disease, but now Next-generation sequencing (NGS) has replaced the Microarray technology. From the last few years, RNA sequence (RNA-Seq) data are widely used for the transcriptomic analysis. Hence, RNA-Seq based classification of disease is in its infancy. In this article, we present a general framework for the classification of disease constructed on RNA-Seq data. This framework will guide the researchers to process RNA-Seq, extract relevant features and apply the appropriate classifier to classify any kind of disease.
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Acknowledgements
The authors acknowledge Dr. Khalid Raza, Department of Computer Science, Jamia Millia Islamia for necessary discussion and suggestion on the manuscript.
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Iqbal, N., Kumar, P. (2020). A Framework for the RNA-Seq Based Classification and Prediction of Disease. In: Kumar, A., Paprzycki, M., Gunjan, V. (eds) ICDSMLA 2019. Lecture Notes in Electrical Engineering, vol 601. Springer, Singapore. https://doi.org/10.1007/978-981-15-1420-3_8
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DOI: https://doi.org/10.1007/978-981-15-1420-3_8
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