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Periostin and Human Teeth

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Book cover Periostin

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1132))

Abstract

Periostin is a secreted matricellular protein that primarily interacts with type I collagen and fibronectin extracellular matrix proteins, and is widely distributed in tissues rich in collagen-rich connective tissues, including the periodontal ligament. Its expression in these tissues is especially regulated by mechanical load. While the expression and regulation of periostin in the teeth of murine models and cell lines is well known, its presence in human teeth is poorly documented. Here we update and summarize the available data on the distribution of periostin in the human periodontal ligament, gingiva and dental pulp.

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References

  1. Afanador E, Yokozeki M, Oba Y, Kitase Y, Takahashi T, Kudo A, Moriyama K (2005) Messenger RNA expression of Periostin and Twist transiently decrease by occlusal hypofunction in mouse periodontal ligament. Arch Oral Biol 50:1023–1031

    Article  CAS  Google Scholar 

  2. Avery JK, Chiego DJ (2006) Essentials of oral histology and embryology: a clinical approach, 3rd edn. Mosby/Elsevier, St. Louis

    Google Scholar 

  3. Balli U, Keles ZP, Avci B, Guler S, Cetinkaya BO, Keles GC (2015) Assessment of periostin levels in serum and gingival crevicular fluid of patients with periodontal disease. J Periodontal Res 50:707–713

    Article  CAS  Google Scholar 

  4. Bornstein P, Sage EH (2002) Matricellular proteins: extracellular modulators of cell function. Curr Opin Cell Biol 14:608–616

    Article  CAS  Google Scholar 

  5. Choi JW, Arai C, Ishikawa M, Shimoda S, Nakamura Y (2011) Fiber system degradation, and periostin and connective tissue growth factor level reduction, in the periodontal ligament of teeth in the absence of masticatory load. J Periodontal Res 46:513–521

    Article  CAS  Google Scholar 

  6. Cobo T, Obaya A, Cal S, Solares L, Cabo R, Vega JA, Cobo J (2015) Immunohistochemical localization of periostin in human gingiva. Eur J Histochem 59:2548

    Article  CAS  Google Scholar 

  7. Cobo T, Viloria CG, Solares L, Fontanil T, González-Chamorro E, De Carlos F, Cobo J, Cal S, Obaya AJ (2016) Role of periostin in adhesion and migration of bone remodeling cells. PLoS ONE 11(1):e0147837

    Article  Google Scholar 

  8. Conway SJ, Izuhara K, Kudo Y, Litvin J, Markwald R, Ouyang G, Arron JR, Holweg CT, Kudo A (2014) The role of periostin in tissue remodeling across health and disease. Cell Mol Life Sci 71:1279–1288

    Article  CAS  Google Scholar 

  9. Du J, Li M (2017) Functions of Periostin in dental tissues and its role in periodontal tissues’ regeneration. Cell Mol Life Sci 74:4279–4286

    Article  CAS  Google Scholar 

  10. Hoersch S, Andrade-Navarro MA (2010) Periostin shows increased evolutionary plasticity in its alternatively spliced region. BMC Evol Biol 10:30

    Article  Google Scholar 

  11. Horiuchi K, Amizuka N, Takeshita S, Takamatsu H, Katsuura M, Ozawa H, Toyama Y, Bonewald LF, Kudo A (1999) Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta. J Bone Miner Res 14:1239–1249

    Article  CAS  Google Scholar 

  12. Jackson-Boeters L, Wen W, Hamilton DW (2009) Periostin localizes to cells in normal skin, but is associated with the extracellular matrix during wound repair. J Cell Commun Signal 3:125–133

    Article  Google Scholar 

  13. Kii I, Nishiyama T, Kudo A (2016) Periostin promotes secretion of fibronectin from the endoplasmic reticulum. Biochem Biophys Res Commun 470:888–893

    Article  CAS  Google Scholar 

  14. Kruzynska-Frejtag A, Wang J, Maeda M, Rogers R, Krug E, Hoffman S, Markwald RR, Conway SJ (2004) Periostin is expressed within the developing teeth at the sites of epithelial-mesenchymal interaction. Dev Dynam 229:857–868

    Article  CAS  Google Scholar 

  15. Kudo A (2011) Periostin in fibrillogenesis for tissue regeneration: periostin actions inside and outside the cell. Cell Mol Life Sci 68:3201–3207

    Article  CAS  Google Scholar 

  16. Kudo A, Kii I (2018) Periostin function in communication with extracellular matrices. J Cell Commun Signal 12:301–308

    Article  Google Scholar 

  17. Li J, Feng W, Liu B, Sun B, Han X, Du J, Sun J, Yimin Cui J, Guo J, Kudo A, Amizuka N, Li M (2015) Altered distribution of HMGB1 in the periodontal ligament of Periostin-deficient mice subjected to Waldo’s orthodontic tooth movement. J Mol Histol 46:303–311

    Article  Google Scholar 

  18. Lv S, Liu H, Cui J, Hasegawa T, Hongo H, Feng W, Li J, Sun B, Kudo A, Amizuka N, Li M (2014) Histochemical examination of cathepsin K, MMP1 and MMP2 in compressed periodontal ligament during orthodontic tooth movement in Periostin deficient mice. J Mol Histol 45:303–309. 41

    Article  CAS  Google Scholar 

  19. Ma D, Zhang R, Sun Y, Rios HF, Haruyama N, Han X, Kulkarni AB, Qin C, Feng JQ (2011) A novel role of periostin in postnatal tooth formation and mineralization. J Biol Chem 286:4302–4309

    Article  CAS  Google Scholar 

  20. Menéndez-Díaz I, Muriel JD, García-Suárez O, Obaya A, Cal S, Cobo J, Vega JA, Cobo T (2018) Periostin, dentin matrix protein 1 and P2rx7 ion channel in human teeth and periodontal ligament. Ann Anat 216:103–111

    Article  Google Scholar 

  21. Norris RA, Damon B, Mironov V, Kasyanov V, Ramamurthi A, Moreno-Rodriguez R, Trusk T, Potts JD, Goodwin RL, Davis J, Hoffman S, Wen X, Sugi Y, Kern CB, Mjaatvedt CH, Turner DK, Oka T, Conway SJ, Molkentin JD, Forgacs G, Markwald R (2007) Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues. J Cell Biochem 101:695–711

    Article  CAS  Google Scholar 

  22. Ontsuka K, Kotobuki Y, Shiraishi H, Serada S, Ohta S, Tanemura A, , Yang L, Fujimoto M, Arima K, Suzuki S, Murota H, Toda S, Kudo A, Conway SJ, Narisawa Y, Katayama I, Izuhara K, Naka T. Periostin, a matricellular protein, accelerates cutaneous wound repair by activating dermal fibroblasts. Exp Dermatol 2012;21:331–336

    Article  CAS  Google Scholar 

  23. Padial-Molina M, Volk SL, Rios HF (2014) Periostin increases migration and proliferation of human periodontal ligament fibroblasts challenged by tumor necrosis factor -α and Porphyromonas gingivalis lipopolysaccharides. J Periodontal Res 49:405–414

    Article  CAS  Google Scholar 

  24. Qu Y, Chi W, Hua X, Deng R, Li J, Liu Z, Pflugfelder SC, Li DK (2015) Unique expression pattern and functional role of periostin in human limbal stem cells. PLoS One 10:e0117139

    Article  Google Scholar 

  25. Rangiani A, Jing Y, Ren Y, Yadav S, Taylor R, Feng JQ (2016) Critical roles of Periostin in the process of orthodontic tooth movement. Eur J Orthod 38:373–378

    Article  Google Scholar 

  26. Ren Y, Han X, Ho SP, Harris SE, Cao Z, Economides AN, Qin C, Ke H, Liu M, Feng JQ (2015) Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse model. FASEB J 29:2702–2711

    Article  CAS  Google Scholar 

  27. Rios H, Koushik SS, Wang H, Zhou HM, Lindsley A, Rogers R, Chen Z, Maeda M, Kruzynska-Frejtag A, Feng JQ, Conway SJ (2005) Periostin null mice exhibit dwarfism, incisor enamel defects, and an early-onset periodontal disease-like phenotype. Mol Cell Biol 25:11131–11144

    Article  CAS  Google Scholar 

  28. Rios HF, Ma D, Xie Y, Giannobile WV, Bonewald LF, Conway SJ, Feng JQ (2008) Periostin is essential for the integrity and function of the periodontal ligament during occlusal loading in mice. J Periodontol 79:1480–1490

    Article  CAS  Google Scholar 

  29. Roberts DD (2011) Emerging functions of matricellular proteins. Cell Mol Life Sci 68:3133–3136

    Article  CAS  Google Scholar 

  30. Romanos GE, Asnani KP, Hingorani D, Deshmukh VL (2014) PERIOSTIN: role in formation and maintenance of dental tissues. J Cell Physiol 229:1–5

    CAS  PubMed  Google Scholar 

  31. Suzuki H, Amizuka N, Kii I, Kawano Y, Nozawa-Inoue K, Suzuki A, Yoshie H, Kudo A, Maeda T (2004) Immunohistochemical localization of periostin in tooth and its surrounding tissues in mouse mandibles during development. Anat Rec A Discov Mol Cell Evol Biol 281:1264–1275

    Article  Google Scholar 

  32. Tang Y, Liu L, Wang P, Chen D, Wu Z, Tang C (2017) Periostin promotes migration and osteogenic differentiation of human periodontal ligament mesenchymal stem cells via the Jun amino-terminal kinases (JNK) pathway under inflammatory conditions. Cell Prolif 50(6). https://doi.org/10.1111/cpr.12369

    Article  Google Scholar 

  33. Tomokiyo A, Maeda H, Fujii S, Wada N, Shima K, Akamine A (2008) Development of a multipotent clonal human periodontal ligament cell line. Differentiation 76:337–347

    Article  CAS  Google Scholar 

  34. Watanabe T, Yasue A, Fujihara S, Tanaka E (2012) PERIOSTIN regulates MMP-2 expression via the alphavbeta3 integrin/ERK pathway in human periodontal ligament cells. Arch Oral Biol 57:52–59

    Article  CAS  Google Scholar 

  35. Wiesen RM, Padial-Molina M, Volk SL, McDonald N, Chiego D Jr, Botero T, Rios HF (2015) The expression of periostin in dental pulp cells. Arch Oral Biol 60:760–767

    Article  CAS  Google Scholar 

  36. Wilde J, Yokozeki M, Terai K, Kudo A, Moriyama K (2003) The divergent expression of periostin mRNA in the periodontal ligament during experimental tooth movement. Cell Tissue Res 312:345–351

    Article  CAS  Google Scholar 

  37. Xu HY, Nie EM, Deng G, Lai LZ, Sun FY, Tian H, Fang FC, Zou YG, Wu BL, Ou-Yang J (2017) Periostin is essential for periodontal ligament remodeling during orthodontic treatment. Mol Med Rep 15:1800–1806

    Article  CAS  Google Scholar 

  38. Yamada S, Tauchi T, Awata T, Maeda K, Kajikawa T, Yanagita M, Murakami S (2014) Characterization of a novel periodontal ligament-specific periostin isoform. J Dent Res 93:891–897

    Article  CAS  Google Scholar 

  39. Yu KW, Yao CC, Jeng JH, Shieh HY, Chen YJ (2018) Periostin inhibits mechanical stretch-induced apoptosis in osteoblast-like MG-63 cells. J Formos Med Assoc 117:292–300

    Article  CAS  Google Scholar 

  40. Zhou M, Kawashima N, Suzuk N, Yamamoto M, Ohnishi K, Katsube KI, Tanabe H, Kudo A, Saito M, Suda H (2015) Periostin is a negative regulator of mineralization in the dental pulp tissue. Odontology 103:152–159

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Departamento de Cirugía y Especialidades Médico-Quirúrgicas, Universidad de Oviedo, Oviedo, Spain

    Teresa Cobo & Juan Cobo

  2. Instituto Asturiano de Odontología, Oviedo, Spain

    Teresa Cobo & Juan Cobo

  3. Servicio de Cirugía Maxilofacial, Hospital Universitario Central de Asturias, Oviedo, Spain

    Juan L. Cobo

  4. Departamento de Morfología y Biología Celular, Universidad de Oviedo, Oviedo, Spain

    Juan L. Cobo & José A. Vega

  5. Departamento de Estomatología, Universidad de Santiago de Compostela, Santiago, Spain

    Juan C. Pérez-Varela

  6. Facultad de Ciencias Médicas, Universidad Autónoma de Chile, Providencia, Chile

    José A. Vega

Authors
  1. Teresa Cobo
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  2. Juan L. Cobo
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  3. Juan C. Pérez-Varela
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  4. José A. Vega
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  5. Juan Cobo
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Editor information

Editors and Affiliations

  1. International Frontier, Tokyo Institute of Technology, Tokyo, Japan

    Akira Kudo

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© 2019 Springer Nature Singapore Pte Ltd.

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Cobo, T., Cobo, J.L., Pérez-Varela, J.C., Vega, J.A., Cobo, J. (2019). Periostin and Human Teeth. In: Kudo, A. (eds) Periostin. Advances in Experimental Medicine and Biology, vol 1132. Springer, Singapore. https://doi.org/10.1007/978-981-13-6657-4_8

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