Abstract
Flavonoids comprise a large group of polyphenolic compounds with well-documented biological activities, like antioxidant, anti-inflammatory, antitumor, antiviral, and antiallergic. Flavonoids are structurally divided into eight different groups: flavones (e.g., luteolin), flavonols (e.g., quercetin), flavanones (e.g., naringenin), flavanonols (e.g., epigallocatechin gallate), isoflavones (e.g., genistein), anthocyanidins (e.g., cyanidin), dihydroflavonols, and chalcones. Out of the first six groups, we have selected one representative, given in parenthesis, which has been reported for a wide spectrum of its biological effects. The aim of this study is to summarize the knowledge gathered in regard to the metal complexation sites in flavonoids, the anticancer and chemopreventive activities of six selected natural flavonoids and their metal complexes, as well as patent highlights related to their anticancer therapeutic potential. Recent studies investigating the interaction of flavonoids with diverse molecular targets and signaling pathways have been given a special attention, since these may suggest directions for future research.
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Uivarosi, V., Munteanu, A.C., Sharma, A., Singh Tuli, H. (2019). Metal Complexation and Patent Studies of Flavonoid. In: Singh Tuli, H. (eds) Current Aspects of Flavonoids: Their Role in Cancer Treatment . Springer, Singapore. https://doi.org/10.1007/978-981-13-5874-6_4
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