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Mechanism Development of Accommodation and Tolerance in Transplant

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ABO-incompatible Organ Transplantation

Abstract

Administration of immunosuppressants in transplanted recipients promotes the allograft acceptance but also leads to serious side effects. Aiming at solving this issue in allotransplantation, researchers have paid attention to manipulate the immune response so as to induce an allograft tolerance (in which the immune response to foreign antigen or an allograft is selectively abolished due to generalized non-responsiveness or loss of the antigenic target) without immunosuppressants rather than unspecific immunosuppression. It is interesting to observe that until anti-blood group antibodies went back to normal levels in recipients several days after ABO-incompatible (ABOi) renal transplantation, there was still no allograft rejection in most of the recipients. The survival of ABOi-transplanted organs in coexistence with anti-allograft antibodies and complement which originally results in graft rejection was described as accommodation. Is this successful engraftment of ABOi allografts (accommodation) a certain level or type of allograft tolerance, or does it just reflect some other biological condition of allografts? Thus, the mechanism investigation of accommodation and tolerance could be significant for conquering humoral barriers to allotransplantation and promoting long-term survival of allografts.

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Authors and Affiliations

  1. Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China

    Jina Wang & Ruiming Rong

  2. Shanghai Key Laboratory of Organ Transplantation, Shanghai, China

    Jina Wang & Ruiming Rong

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  1. Jina Wang
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  2. Ruiming Rong
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Correspondence to Ruiming Rong .

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Editors and Affiliations

  1. The Second Affiliated Hospital of Hainan, Medical University, Haikou, Hainan, China

    Yi Wang

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Wang, J., Rong, R. (2019). Mechanism Development of Accommodation and Tolerance in Transplant. In: Wang, Y. (eds) ABO-incompatible Organ Transplantation. Springer, Singapore. https://doi.org/10.1007/978-981-13-3399-6_15

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  • DOI: https://doi.org/10.1007/978-981-13-3399-6_15

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