Skip to main content

General Principles of Neurocritical Care

  • Chapter
  • First Online:
Textbook of Neuroanesthesia and Neurocritical Care

Abstract

Neurocritical care (NCC) refers to the care and examination of the comatose patient; treatment of raised intracranial pressure (ICP) and neuromuscular respiratory failure; use of therapies specific for acute stroke, ICH, SAH, TBI, and status epilepticus, among other conditions; and treatment of medical complications typical for acute neurologic illness. The pivotal aspect of NCC involves providing intensive monitoring to critically ill neurological patients and thus requires the support of specially trained personnel with skills to identify subtle neurologic changes which remain the best markers for worsening injury. The neurointensivist plays a central role, directing medical care, triaging patients, and managing ICU resources. In addition, the critical care provider team also consists of residents, fellows, and/or physician extenders. Ideally such a team should be available 24 h a day to provide continuous monitoring and care. Like any other critically ill patient, management of the neurocritically ill patient begins with ensuring a secured airway, adequate ventilation, and circulation. This is followed by a rapid neurological assessment to grade the level of consciousness and elucidate the cause and severity of injury in order to identify immediate interventions such as ICP control. Once stable, appropriate radiological studies are obtained to confirm the suspected diagnosis followed by specific therapies including neurosurgical interventions. In this chapter, we review the principles of NCC, current neuromonitoring approaches, and the best treatment maneuvers available.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Ropper AH. Neurological and neurosurgical intensive care. Baltimore: Univ. Park Press; 1983.

    Google Scholar 

  2. Wijdicks EFM, Kramer AH. Critical care neurology part I: neurocritical care. Oxford: Elsevier Science; 2017.

    Google Scholar 

  3. Ropper AH. Neurological intensive care. Ann Neurol. 1992 Oct;32(4):564–9.

    Article  CAS  Google Scholar 

  4. Bleck TP. Historical aspects of critical care and the nervous system. Crit Care Clin. 2009;25(1):153–64.

    Article  Google Scholar 

  5. Multz AS, Chalfin DB, Samson IM, Dantzker DR, Fein AM, Steinberg HN, et al. A “closed” medical intensive care unit (MICU) improves resource utilization when compared with an “open” MICU. Am J Respir Crit Care Med. 1998;157(5 Pt 1):1468.

    Article  CAS  Google Scholar 

  6. Ghorra S, Reinert SE, Cioffi W, Buczko G, Simms HH. Analysis of the effect of conversion from open to closed surgical intensive care unit. Ann Surg. 1999;229(2):163–71.

    Article  CAS  Google Scholar 

  7. Chase CM, Ulatowski J, editors. Organization of the neuroscience critical care unit. 1st ed. Berlin: Springer; 2004.

    Google Scholar 

  8. Mirski MA, Chang CW, Cowan R. Impact of a neuroscience intensive care unit on neurosurgical patient outcomes and cost of care: evidence-based support for an intensivist-directed specialty ICU model of care. J Neurosurg Anesthesiol. 2001;13(2):83–92.

    Article  CAS  Google Scholar 

  9. Diringer M, Edwards D. Admission to a neurologic/neurosurgical intensive care unit is associated with reduced mortality rate after intracerebral hemorrhage. Crit Care Med. 2001;29(3):635–40.

    Article  CAS  Google Scholar 

  10. Suarez J, Zaidat O, Suri M, Feen E, Lynch G, Hickman J, et al. Length of stay and mortality in neurocritically ill patients: impact of a specialized neurocritical care team. Crit Care Med. 2004;32(11):2311–7.

    Article  Google Scholar 

  11. Varelas P, Conti M, Spanaki M, Potts E, Bradford D, Sunstrom C, et al. The impact of a neurointensivist-led team on a semiclosed neurosciences intensive care unit. Crit Care Med. 2004;32(11):2191–8.

    Article  Google Scholar 

  12. Kramer AH, Zygun DA. Neurocritical care: why does it make a difference? Curr Opin Crit Care. 2014;20(2):174.

    Article  Google Scholar 

  13. Kurtz P, Fitts V, Sumer Z, Jalon H, Cooke J, Kvetan V, et al. How does care differ for neurological patients admitted to a neurocritical care unit versus a general ICU? Neurocrit Care. 2011;15(3):477–80.

    Article  Google Scholar 

  14. Markandaya M, Thomas K, Jahromi B, Koenig M, Lockwood A, Nyquist P, et al. The role of neurocritical care: a brief report on the survey results of neurosciences and critical care specialists. Neurocrit Care. 2012;16(1):72–81.

    Article  Google Scholar 

  15. Suarez J. Outcome in neurocritical care: advances in monitoring and treatment and effect of a specialized neurocritical care team. Crit Care Med. 2006 Sep;34(9 Suppl):S238.

    Google Scholar 

  16. Posner JB, Saper CB, Schiff N, Plum F. Plum and Posner’s diagnosis of stupor and coma. 4th ed. Cary: Oxford University Press; 2007.

    Google Scholar 

  17. Ropper AH. Lateral displacement of the brain and level of consciousness in patients with an acute hemispheral mass. N Engl J Med. 1986;314(15):953.

    Article  CAS  Google Scholar 

  18. Teasdale G, Jennett B. Assessment of coma and impaired consciousness. A practical scale. Lancet. 1974;2(7872):81.

    Article  CAS  Google Scholar 

  19. Teasdale G, Knill-Jones R, van der Sande J. Observer variability in assessing impaired consciousness and coma. J Neurol Neurosurg Psychiatry. 1978;41(7):603–10.

    Article  CAS  Google Scholar 

  20. Hemphill JC 3rd, Bonovich DC, Besmertis L, Manley GT, Johnston SC. The ICH score: a simple, reliable grading scale for intracerebral hemorrhage. Stroke. 2001;32(4):891.

    Article  Google Scholar 

  21. Wijdicks EFM, Bamlet WR, Maramattom BV, Manno EM, McClelland RL. Validation of a new coma scale: the FOUR score. Ann Neurol. 2005;58(4):585–93.

    Article  Google Scholar 

  22. Fischer M, Rüegg S, Czaplinski A, Strohmeier M, Lehmann A, Tschan F, et al. Inter-rater reliability of the Full Outline of UnResponsiveness score and the Glasgow Coma Scale in critically ill patients: a prospective observational study. Crit Care. 2010;14(2):R64.

    Article  Google Scholar 

  23. Georgiadis A, Geocadin R, Suarez JI, Zaidat O. Coma and brain death. In: Suarez JI, editor. Critical care neurology and neurosurgery. Totowa: Humana Press; 2004. p. 301–14.

    Chapter  Google Scholar 

  24. Vespa PM, MD. Imaging and decision-making in neurocritical care. Neurol Clin. 2014;32(1):211–24.

    Article  Google Scholar 

  25. Le Roux P, Menon DK, Citerio G, Vespa P, Bader MK, Brophy G, et al. The International Multidisciplinary Consensus Conference on Multimodality Monitoring in Neurocritical Care: a list of recommendations and additional conclusions: a statement for healthcare professionals from the Neurocritical Care Society and the European Society of Intensive Care Medicine. Neurocrit Care. 2014;21(S2):282.

    Article  Google Scholar 

  26. Czosnyka M, Pickard J, Steiner L. Principles of intracranial pressure monitoring and treatment. In: Wijidicks E, Kramer AH, editors. Handbook of clinical neurology. New York: Elsevier; 2017. p. 67–89.

    Google Scholar 

  27. Schell RM, Cole DJ. Cerebral monitoring: jugular venous oximetry. Anesth Analg. 2000;90(3):559–66.

    Article  CAS  Google Scholar 

  28. Frontera J, Ziai W, O’Phelan K, Leroux P, Kirkpatrick P, Diringer M, et al. Regional brain monitoring in the neurocritical care unit. Neurocrit Care. 2015;22(3):348–59.

    Article  CAS  Google Scholar 

  29. Jantzen JP. Prevention and treatment of intracranial hypertension. Best Pract Res Clin Anaesthesiol. 2007;21(4):517–38.

    Article  Google Scholar 

  30. Mokri B. The Monro-Kellie hypothesis: applications in CSF volume depletion. Neurology. 2001;56(12):1746–8.

    Article  CAS  Google Scholar 

  31. Ropper AH. Hyperosmolar therapy for raised intracranial pressure. N Engl J Med. 2012;367(8):746.

    Article  CAS  Google Scholar 

  32. Treggiari M, Schutz N, Yanez N, Romand J. Role of intracranial pressure values and patterns in predicting outcome in traumatic brain injury: a systematic review. Neurocrit Care. 2007;6(2):104–12.

    Article  Google Scholar 

  33. Miller JD, Stanek A, Langfitt TW. Concepts of cerebral perfusion pressure and vascular compression during intracranial hypertension. Prog Brain Res. 1972;35:411.

    Article  CAS  Google Scholar 

  34. Lassen NA. Autoregulation of cerebral blood flow. Circ Res. 1964;15(suppl):201–4.

    CAS  Google Scholar 

  35. Carney N, Totten AM, O'Reilly C, Ullman JS, Hawryluk GWJ, Bell MJ, et al. Guidelines for the management of severe traumatic brain injury, fourth edition. Neurosurgery. 2017;80(1):6–15.

    PubMed  Google Scholar 

  36. Stocchetti N, Maas AIR. Traumatic intracranial hypertension. N Engl J Med. 2014;370(22):2121.

    Article  Google Scholar 

  37. Muizelaar JP, Wei EP, Kontos HA, Becker DP. Mannitol causes compensatory cerebral vasoconstriction and vasodilation in response to blood viscosity changes. J Neurosurg. 1983;59(5):822–8.

    Article  CAS  Google Scholar 

  38. Curley G, Kavanagh BP, Laffey JG. Hypocapnia and the injured brain: more harm than benefit. Crit Care Med. 2010;38(5):1348–59.

    Article  Google Scholar 

  39. Cooper DJ, Rosenfeld JV, Murray L, Arabi YM, Davies AR, D’Urso P, et al. Decompressive craniectomy in diffuse traumatic brain injury. N Engl J Med. 2011;364(16):1493–502.

    Article  CAS  Google Scholar 

  40. Nyquist P, Stevens R, Mirski M. Neurologic injury and mechanical ventilation. Neurocrit Care. 2008;9(3):400–8.

    Article  Google Scholar 

  41. Seder DB, Bosel J, editors. Airway management and mechanical ventilation in acute brain injury. New York: Elsevier; 2017.

    Google Scholar 

  42. Wendell LC, Levine JM. Myasthenic crisis. Neurohospitalist. 2011;1(1):16–22.

    Article  Google Scholar 

  43. Seder D, Jagoda A, Riggs B. Emergency neurological life support: airway, ventilation, and sedation. Neurocrit Care. 2015;23(S2):5–22.

    Article  CAS  Google Scholar 

  44. Bucher J, Koyfman A. Intubation of the neurologically injured patient. J Emerg Med. 2015;49(6):920–7.

    Article  Google Scholar 

  45. Cohen L, Athaide V, Wickham ME, Doyle-Waters MM, Rose NGW, Hohl CM. The effect of ketamine on intracranial and cerebral perfusion pressure and health outcomes: a systematic review. Ann Emerg Med. 2014;65(1):51.e2.

    Google Scholar 

  46. Kovarik W, Mayberg T, Lam A, Mathisen T, Winn H. Succinylcholine does not change intracranial pressure, cerebral blood flow velocity, or the electroencephalogram in patients with neurologic injury. Anesth Analg. 1994;78(3):469–73.

    Article  CAS  Google Scholar 

  47. Schirmer-Mikalsen K, Vik A, Skogvoll E, Moen K, Solheim O, Klepstad P. Intracranial pressure during pressure control and pressure-regulated volume control ventilation in patients with traumatic brain injury: a randomized crossover trial. Neurocrit Care. 2016;24(3):332–41.

    Article  Google Scholar 

  48. The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000;342(18):1301–8.

    Article  Google Scholar 

  49. Marhong J, Ferguson N, Singh J. Ventilation practices in subarachnoid hemorrhage: a cohort study exploring the use of lung protective ventilation. Neurocrit Care. 2014;21(2):178–85.

    Article  Google Scholar 

  50. Mrozek S, Constantin J, Geeraerts T. Brain-lung crosstalk: implications for neurocritical care patients. World J Crit Care Med. 2015;4(3):163.

    Article  Google Scholar 

  51. Godet T, Chabanne R, Marin J, Kauffmann S, Futier E, Pereira B, et al. Extubation failure in brain-injured patients: risk factors and development of a prediction score in a preliminary prospective cohort study. Anesthesiology. 2017;126(1):104–14.

    Article  Google Scholar 

  52. Cipolla MJ. The cerebral circulation. 2nd ed. San Rafael: Morgan & Claypool Life Sciences; 2016.

    Google Scholar 

  53. Ginsberg MD, Palesch YY, Hill MD, Martin RH, Moy CS, Barsan WG, et al. High-dose albumin treatment for acute ischaemic stroke (ALIAS) part 2: a randomised, double-blind, phase 3, placebo-controlled trial. Lancet Neurol. 2013;12(11):1049–58.

    Article  CAS  Google Scholar 

  54. The SAFE Study Investigators. Saline or albumin for fluid resuscitation in patients with traumatic brain injury. N Engl J Med. 2007;357(9):874–84.

    Article  Google Scholar 

  55. Suarez JI, Shannon L, Zaidat OO, Suri MF, Singh G, Lynch G, et al. Effect of human albumin administration on clinical outcome and hospital cost in patients with subarachnoid hemorrhage. J Neurosurg. 2004;100(4):585–90.

    Article  CAS  Google Scholar 

  56. Oddo M, Poole D, Helbok R, Meyfroidt G, Stocchetti N, Bouzat P, et al. Fluid therapy in neurointensive care patients: ESICM consensus and clinical practice recommendations. Intensive Care Med. 2018;44(4):449–63.

    Article  Google Scholar 

  57. Aiyagari V, Deibert E, Diringer MN. Hypernatremia in the neurologic intensive care unit: how high is too high? J Crit Care. 2006;21(2):163–72.

    Article  Google Scholar 

  58. Sadan O, Singbartl K, Kandiah P, Martin K, Samuels O. Hyperchloremia is associated with acute kidney injury in patients with subarachnoid hemorrhage. Crit Care Med. 2017;45(8):1382–8.

    Article  CAS  Google Scholar 

  59. Riha H, Erdman M, Vandigo J, Kimmons L, Goyal N, Davidson K, et al. Impact of moderate hyperchloremia on clinical outcomes in intracerebral hemorrhage patients treated with continuous infusion hypertonic saline: a pilot study. Crit Care Med. 2017;45(9):e953.

    Article  Google Scholar 

  60. Zarbock S, Steinke D, Hatton J, Magnuson B, Smith K, Cook A. Successful enteral nutritional support in the neurocritical care unit. Neurocrit Care. 2008;9(2):210–6.

    Article  Google Scholar 

  61. Nyquist P, Bautista C, Jichici D, Burns J, Chhangani S, DeFilippis M, et al. Prophylaxis of venous thrombosis in neurocritical care patients: an evidence-based guideline: a statement for healthcare professionals from the Neurocritical Care Society. Neurocrit Care. 2016;24(1):47–60.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jose I. Suarez .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Shah, V., Suarez, J.I. (2019). General Principles of Neurocritical Care. In: Prabhakar, H., Ali, Z. (eds) Textbook of Neuroanesthesia and Neurocritical Care. Springer, Singapore. https://doi.org/10.1007/978-981-13-3390-3_1

Download citation

  • DOI: https://doi.org/10.1007/978-981-13-3390-3_1

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-3389-7

  • Online ISBN: 978-981-13-3390-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics