Abstract
All reactions relevant to biology belong to one of the two groups: those with a kinetic barrier and those with a thermodynamic barrier. The kinetic barrier can be overcome by employing a catalyst. Reactions with a thermodynamic barrier (uphill, endergonic reactions) require provision of energy (such as ATP hydrolysis) in addition to a catalyst. Regardless of the nature of barriers faced, greater than 99% of all the reactions occurring in biological systems are catalyzed. With minor exception of a few RNA catalysts (ribozymes), all the enzymes are built from a protein scaffold. These catalysts par excellence are at the very foundation of life. The three hallmark features of these biocatalysts are catalysis, specificity, and regulation.
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Punekar, N.S. (2018). Hallmarks of an Enzyme Catalyst. In: ENZYMES: Catalysis, Kinetics and Mechanisms. Springer, Singapore. https://doi.org/10.1007/978-981-13-0785-0_5
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DOI: https://doi.org/10.1007/978-981-13-0785-0_5
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