Skip to main content

Potentiality of Anticancer Plant-Derived Compounds of North-East India

  • Chapter
  • First Online:
Anticancer plants: Properties and Application

Abstract

North-East India is known for the diversified range of medicinal plants which may extensively be used in the traditional medicinal practices against various ailments. Isolation of plant-derived bioactive compounds from these medicinal plants was well recognized in the past decades and some of them have been approved as medicines against diseases including cancer. It is expected that the number of new cancer cases is to soar by 70% in the next 20 years. Thus, there is a need to seek the new anticancer drugs, which have no side effects. In this regard complementary alternate medicines (CAMs) derived from plants could be a promising source against the cancer and related diseases. The aim of the present chapter is to focus on the potentiality of major plant-derived compounds from diversified medicinal plants of North-East India for their anticancer and chemopreventive activity and their mode of action. Moreover, their large-scale production, uses of their structural analogs, and molecular docking studies of some of the selected plant-derived compounds are also discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Abdullah S, Abidin SAZ (2010) Ginger extract (Zingiber officinale) triggers apoptosis and G0/G1 cells arrest in HCT 116 and HT 29 colon cancer cell lines. Afr J Biochem Res 4:134–142

    Google Scholar 

  • ACS (2016) Cancer facts and figures 2016 special section: cancer in Asian Americans, Native Hawaiians, and Pacific Islanders. American Cancer Society, Atlanta, pp 35–42

    Google Scholar 

  • Adebayo AH, Tan NH, Akindahunsi AA, Zeng GZ, Zhang YM (2010) Anticancer and antiradical scavenging activity of Ageratum conyzoides L. (Asteraceae). Pharmacogn Mag 6:62–66

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Aggarwal BB, Shishodia S (2005) Curcumin suppresses the Paclitaxel induced nuclear factor-KB pathway in breast cancer cells and inhibits lung metastasis of human breast. Clin Cancer Res 11:7490–7498

    Article  CAS  PubMed  Google Scholar 

  • Aggarwal BB, Kumar A, Bharti AC (2003) Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res 23:363–398

    PubMed  CAS  Google Scholar 

  • Baliga MS, Jimmy R, Thilakchand KR, Sunitha V, Bhat NR, Saldanha E, Rao S, Rao P, Arora R, Palatty PL (2013) Ocimum sanctum L. (Holy Basil or Tulsi) and its phytochemicals in the prevention and treatment of cancer. Nutr Cancer 65:S26–S35

    Article  CAS  Google Scholar 

  • Baral R, Chattopadhyay U (2004) Neem (Azadirachta indica) leaf mediated immune activation causes prophylactic growth inhibition of murine ehrlich carcinoma and B16 melanoma. Int Immunopharmacol 4:355–366

    Article  CAS  PubMed  Google Scholar 

  • Baselga J, Norton L, Albanell J, Kim YM, Mendelsohn J (1998) Recombinant humanized anti-HER2 antibody enhances the antitumor activity of Paclitaxel and Doxorubicin against HER2/neu overexpressing human breast cancer xenografts. Cancer Res 58:2825–2831

    PubMed  CAS  Google Scholar 

  • Behere PB, Das A, Yadav R, Behere AP (2013) Ayurvedic concepts related to psychotherapy. Indian J Psychiatry 55:S310–S314

    Article  PubMed  PubMed Central  Google Scholar 

  • Brunakova K, Babincova Z, Takac M, Cellarova E (2004) Selection of callus cultures of Taxus baccata L. as a potential source of Paclitaxel production. Eng Life Sci 4:465–469

    Article  CAS  Google Scholar 

  • Brunakova K, Babincova Z, Cellarova E (2005) Production of taxanes in callus and suspension cultures of Taxus baccata L. In: Hvoslef-Eide AK, Preil W (eds) Liquid culture systems for in vitro plant propagation. Springer, The Netherlands, pp 567–574

    Chapter  Google Scholar 

  • Casanova ML, Blazquez C, Martinez-Palacio J, Villanueva C, Fernandez-Acenero MJ, Huffman JW, Jorcano JL, Manuel Guzman M (2003) Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. J Clin Invest 111:43–50

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cheung S, Tai J (2007) Anti-proliferative and antioxidant properties of rosemary Rosmarinus officinalis. Oncol Rep 17:1525–1531

    PubMed  Google Scholar 

  • Cui SX, Qu XJ, Xie YY, Zhou L, Nakata M, Makuuchi M, Tang W (2006) Curcumin inhibits telomerase activity in human cancer cell lines. Int J Mol Med 18:227–231

    PubMed  CAS  Google Scholar 

  • David A, Plasitra V (1974) Histophysiologie vegetale realisation de cultures de tissues d’If (Taxus baccata L.) a partir de fragments de pousses ages d’un an; obtention d’une culture indefinie. CR Acad Sci Paris 279:1757–1759

    Google Scholar 

  • David A, Plastira V (1976) Histophysiologie vegetale. Comportement en culture in vitro de cellules isolees de deux gymnospermes: Taxus baccata L. et Pinus pinaster Sol. CR Acad Sci Paris 110:5917–5919

    Google Scholar 

  • De Petrocellis L, Melck D, Palmisano A, Bisogno T, Laezza C, Bifulco M, Di Marzo V (1998) The endogenous cannabinoid an and amide inhibits human breast cancer cell proliferation. Proc Natl Acad Sci USA 95:8375–8380

    Article  PubMed  PubMed Central  Google Scholar 

  • Fridlender M, Kapulnik Y, Koltai H (2015) Plant derived substances with anticancer activity: from folklore to practice. Front Plant Sci 6:799

    Article  PubMed  PubMed Central  Google Scholar 

  • Gandhi D, Mehta P (2013) Dillenia indica Linn. and Dillenia pentagyna Roxb.: pharmacognostic, phytochemical and therapeutic aspects. J Appl Pharma Sci 3:134–142

    CAS  Google Scholar 

  • Giri A, Lakshmi Narasu M (2000) Production of podophyllotoxin from Podophyllum hexandrum: a potential natural product for clinically useful anticancer drugs. Cytotechnology 34:17–26

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gogoi J, Nakhuru KS (2016) Isolation and characterization of bioactive components from Mirabilis jalapa L. radix. J Tradit Complement Med 6:41–47

    Article  PubMed  Google Scholar 

  • Gordaliza M (2007) Natural products as leads to anticancer drugs. Clin Transl Oncol 9:767–776

    Article  CAS  PubMed  Google Scholar 

  • Grotenhermen F, Muller-Vahl K (2012) The therapeutic potential of cannabis and cannabinoids. Dtsch Arztebl Int 109:495–501

    PubMed  PubMed Central  Google Scholar 

  • Guo BH, Kai GY, Jin HB, Tang KX (2006) Taxol synthesis. Afr J Biotechnol 5:15–20

    CAS  Google Scholar 

  • Hashimoto T, Ashida H, Sano T, Furuyashiki T, Shiotani B, Kanazawa K, Danno G (2000) 3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole(Trp-P-1) induces apoptosis in rat splenocytes and thymocytes by different mechanisms. Mutat Res 457:57–67

    Article  CAS  PubMed  Google Scholar 

  • Hossan MS, Rahman S, Bashar ABMA, Jahan R, Al-Nahain A, Rahmatullah M (2014) Rosmarinic acid: a review of its anticancer action. World J Pharm Pharm Sci 3:57–70

    Google Scholar 

  • Hsu CP, Lin CC, Huang CC, Lin YH, Chou JC, Tsia YT, Su JR, Chung YC (2012) Induction of apoptosis and cell cycle arrest in human colorectal carcinoma by litchi seed extract. J Biomed Biotechnol 2012:341479. https://doi.org/10.1155/2012/341479

    Article  PubMed  PubMed Central  Google Scholar 

  • Hussain A, Sharma C, Khan S, Shah K, Haque S (2015) Aloe vera inhibits proliferation of human breast and cervical cancer cells and acts synergistically with cisplatin. Asian Pac J Cancer Prev 16:2939–2946

    Article  PubMed  Google Scholar 

  • Kim JS (2008) Cytotoxic components from the dried rhizomes of Zingiber officinale Roscoe. Arch Pharm Res 31:415

    Article  CAS  PubMed  Google Scholar 

  • Kingston DG (2000) Recent advances in the chemistry of taxol. J Nat Prod 63:726–734

    Article  CAS  PubMed  Google Scholar 

  • Klauber N, Parangi S, Flynn E, Hamel E, D’Amato RJ (1997) Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol. Cancer Res 57:81–86

    PubMed  CAS  Google Scholar 

  • Kumar S, Suresh PK, Vijayababu MR, Arunkumar A, Arunakaran J (2006) Anticancer effects of ethanolic neem leaf extract on prostate cancer cell line (PC-3). J Ethnopharmacol 105:246–250

    Article  CAS  PubMed  Google Scholar 

  • Lee J, Kim JH (2016) Kaempferol inhibits pancreatic cancer cell growth and migration through the blockade of EGFR-related pathway in vitro. PLoS One 11:e0155264

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ligresti A, Bisogno T, Matias I, De Petrocellis L, Cascio MG, Cosenza V, D’argenio G, Scaglione G, Bifulco M, Sorrentini I, Di Marzo V (2003) Possible endocannabinoid control of colorectal cancer growth. Gastroenterology 125:677–687

    Article  CAS  PubMed  Google Scholar 

  • Ligresti A, Moriello AS, Starowicz K, Matias I, Pisanti S, De Petrocellis L, Laezza C, Portella G, Bifulco M, Di Marzo V (2006) Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma. J Pharma Exp Therap 318:1375–1387

    Article  CAS  Google Scholar 

  • Lipinsky CA, Lombardo F, Dominy BW, Feeney PJ (1997) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 46:3–26

    Article  Google Scholar 

  • Magesh V, Lee JC, Ahn KS, Lee HJ, Lee HJ, Lee EO, Shim BS, Jung HJ, Kim JS, Kim DK, Choi SH, Ahn KS, Kim SH (2009) Ocimum sanctum induces apoptosis in A549 lung cancer cells and suppresses the in vivo growth of lewis lung carcinoma cells. Phytother Res 23:1385–1391

    Article  CAS  PubMed  Google Scholar 

  • Malik S, Cusido RM, Mirjalili MM, Moyano E, Palazon J, Bonfill M (2011) Production of the anticancer drug taxol in Taxus baccata suspension cultures: a review. Process Biochem 46:23–34

    Article  CAS  Google Scholar 

  • Massa F, Monory K (2006) Endocannabinoids and the gastrointestinal tract. J Endocrinol Investig 29:47–57

    CAS  Google Scholar 

  • Massa F, Storr M, Lutz B (2005) The endocannabinoid system in the physiology and pathophysiology of the gastrointestinal tract. J Mol Med 83:944–954

    Article  CAS  PubMed  Google Scholar 

  • Massi P, Vaccani A, Ceruti S, Colombo A, Abbracchio MP, Parolaro D (2004) Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines. J Pharma Exp Therap 3:838–845

    Google Scholar 

  • Mbaveng AT, Kuete V, Mapunya BM, Beng VP, Nkengfack AE, Meyer JJM, Lall N (2011) Evaluation of four Cameroonian medicinal plants for anticancer, antigonorrheal and antireverse transcriptase activities. Environ Toxicol Pharmacol 32:162–167

    PubMed  CAS  Google Scholar 

  • Mittal AK, Tripathy D (2015) Biosynthesis of silver nanoparticles using Potentilla fulgens ex wall. hook and its therapeutic evaluation as anticancer and antimicrobial agent. Mater Sci Eng 53:120–127

    Article  CAS  Google Scholar 

  • Mosley CA, Liotta DC, Snyder JP (2007) Highly active anticancer curcumin analogues. Adv Exp Med Biol 595:77–103

    Article  PubMed  Google Scholar 

  • Noorolahi SM, Sadeghi S, Mohammadi M, Azadi M, Rahimi NA, Vahabi F, Arjmand M, Hosseini H, Mosallatpur S, Zamani Z (2016) Metabolomic profiling of cancer cells to Aloe vera extract by 1HNMR spectroscopy. J Metabol 2:1–7. https://doi.org/10.7243/2059-0008-2-1

    Article  Google Scholar 

  • Norikura T, Kojima-Yuasa A, Shimizu M, Huang X, Xu S, Kametani S, Rho SN, Kennedy DO, Matsui-Yuasa I (2008) Mechanism of growth inhibitory effect of Blumea balsamifera extract in Hepatocellular carcinoma. Biosci Biotechnol Biochem 72:1183–1189

    Article  CAS  PubMed  Google Scholar 

  • Osakabe N, Yasuda A, Natsume M, Yoshikawa T (2004) Rosmarinic acid inhibits epidermal inflammatory responses: anti-carcinogenic effect of Perilla frutescens extract in the murine two-stage skin model. Carcinogenesis 25:549–557

    Article  CAS  PubMed  Google Scholar 

  • Parc G, Canaguier A, Landre P, Hocquemiller H, Chriqui D, Meyera M (2002) Production of taxoids with biological activity by plants and callus culture from selected Taxus genotypes. Phytochemistry 59:725–730

    Article  CAS  PubMed  Google Scholar 

  • Priyadarshini K, Aparajitha UK (2012) Paclitaxel against cancer : a short review. Med Chem 2:139–141

    Google Scholar 

  • Prota AE, Bargsten K, Zurwerra D, Field JJ, Díaz JF, Altmann KH, Steinmetz MO (2013) Molecular mechanism of action of microtubule-stabilizing anticancer agents. Science 339:587–590

    Article  CAS  PubMed  Google Scholar 

  • Radhakrishnan E, Bava SV, Narayanan SS, Nath LR, Thulasidasan AKT, Soniya EV, Anto RJ (2014) [6]-Gingerol induces Caspase-dependent apoptosis and prevents PMA-induced proliferation in colon cancer cells by inhibiting MAPK/AP-1 signalling. PLoS One 9:e104401

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Robson P (2001) Therapeutics aspects of cannabis and cannabinoids. Br J Psychiatry 178:107–115

    Article  CAS  PubMed  Google Scholar 

  • Rohr R (1973) Cytologie vegetale. Ultrastructure des spermatozoides de Taxus baccata L. obtenus a partir de cultures aseptiques de microspores sur un milieu artificiel. CR Acad Sci Paris 277:1869–1871

    Google Scholar 

  • Roland CL, Dineen SP, Toombs JE, Carbon JG, Smith CW, Brekken RA, Barnett CC Jr (2010) Tumour-derived intercellular adhesion molecule-1 mediates tumour-associated leukocyte infiltration in orthotopic pancreatic xenografts. Exp Biol Med 235:263–270

    Article  CAS  Google Scholar 

  • Rosangkima G, Prasad SB (2007) Changes in endogenous glutathione level associated with the antitumor activity of the stem bark extract of Dillenia pentagyna against Murine Ascites Dalton’s. Pharmacology 2:11–19

    Google Scholar 

  • Rosangkima G, Rongpi T, Prasad SB (2010) Ethno-medicinal value of some anticancer medicinal plants from north-east India. Sci Vis 10:123–132

    Google Scholar 

  • Roy MK, Kobori M, Takenaka M (2007) Antiproliferative effect on human cancer cell lines after treatment with nimbolide extracted from an edible part of the neem tree (Azadirachta indica) Phytother Res 21:245–250

    Article  CAS  PubMed  Google Scholar 

  • Roya S, Bersa SE, De T, Banerjee B, Mukherjee J, Vedasiromoni JR (2008) Induction of apoptosis in human leukemic cell lines U937, K562 and HL-60 by Litchi chinensis leaf extract via activation of mitochondria mediated caspase cascades. Open Leuk J 1:1–14. https://doi.org/10.2174/1876816400901010001

    Article  Google Scholar 

  • Rumzhum NN, Rahman MM, Islam MS, Chowdhury SA, Sultana R (2008) Cytotoxicity and antioxidant activity of extractives from Mirabilis jalapa. St J Pharm Sci 1:85–88

    Google Scholar 

  • Sharma RA, Gescher AJ, Steward WP (2005) Curcumin: the story so far. Eur J Cancer 41:1955–1968

    Article  CAS  PubMed  Google Scholar 

  • Sharma B, Singh S, Kanwar SS (2014) L-methionase: a therapeutic enzyme to treat malignancies. Bio Med Res Int 2014:13. https://doi.org/10.1155/2014/506287

    Article  CAS  Google Scholar 

  • Siegel RL, Miller KD, Jemal A (2016) Cancer statistics, 2016. CA Cancer J Clin 66:7–30

    Article  PubMed  Google Scholar 

  • Syiem D, Kharbuli B (1999) Medicinal plants and herbal medicine: a case study in Meghalaya. In: Kharbuli B, Syiem D, Kayang H (eds), Biodiversity. North-East India Perspectives Shillong, India, pp 1–8

    Google Scholar 

  • Tai J, Cheunga S (2012) Antiproliferation effect of Rosemary (Rosmarinus officinalis) on human ovarian cancer cells in vitro. Phytomedicine 19:436–443

    Article  CAS  PubMed  Google Scholar 

  • Thun MJ, De Lancey JO (2010) The global burden of cancer: priorities for prevention. Carcinogenesis 31:100–110

    Article  CAS  PubMed  Google Scholar 

  • Tramer MR, Carroll D, Campbell FA, Reynolds DJM, Moore RA, Mcquay HJ (2001) Cannabinoids for control of chemotherapy induced nausea and vomiting quantitative systematic review. BMJ 323:1–8

    Article  Google Scholar 

  • Trevor P, Theodore A (1993) Determination of Taxol in Taxus media needles in the presence of interfering components. J Liq Chromatogr 16:723–731

    Article  Google Scholar 

  • Tushara BS, Sharma SC, Rangan L (2010) Ethnomedical uses of Zingiberaceous plants of Northeast. India J Ethnopharmacol 132:286–296

    Article  Google Scholar 

  • Twentyman PR, Fox NE, White DJ (1987) Cyclosporin A and its analogues as modifiers of adriamycin and vincristine resistance in a multi-drug resistant human lung cancer cell line. Br J Cancer 56:55–57

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Uden WN (1989) Detection and identification of Podophyllotoxin produced by cell cultures derived from Podophyllum hexandrum royle. Plant Cell Rep 8:165–168

    Article  PubMed  Google Scholar 

  • Vaishnav K, George LB, Highland HN (2015) Antitumor activity of Xanthium strumarium L. on human cervical cancer HeLa cells. J Cancer Tum Int 2:1–13

    Article  Google Scholar 

  • Varoni EM, Lo Faro AF, Sharifi-Rad J, Iriti M (2016) Anticancer molecular mechanisms of resveratrol. Front Nutr 3:8. https://doi.org/10.3389/fnut.2016.00008

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Weaver BA (2014) How taxol/paclitaxel kills cancer cells. Mol Biol Cell 25:2677–2268

    Article  PubMed  PubMed Central  Google Scholar 

  • Wilken R, Veena MS, Wang MB, Srivatsan ES (2011) Curcumin: a review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Mol Cancer 10:12. https://doi.org/10.1186/1476-4598-10-12

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Xiao H, Wang H, Zhang X, Tu Z, Bulinski C, Khrapunovich-Baine M, Angeletti RH, Horwitz SB (2012) Structural evidence for cooperative microtubule stabilization by Taxol and the endogenous dynamics regulator MAP 4. ACS Chem Biol 7:744–752

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yesil-Celiktas O, Sevimli C, Bedir E, Vardar-Sukan F (2010) Inhibitory effects of Rosemary extracts, carnosic acid and rosmarinic acid on the growth of various human cancer cell lines plant foods. Human Nutr 65:158–163

    CAS  Google Scholar 

  • Zhao M, Yang B, Wang J, Liu Y, Yu L, Jiang Y (2007) Immunomodulatory and anticancer activities of flavonoids extracted from litchi (Litchi chinensis Sonn.) pericarp. Int Immunopharmacol 7:162–166

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mohan Lal .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Lal, M., Parasar, N.R., Singh, A.K., Akhtar, M.S. (2018). Potentiality of Anticancer Plant-Derived Compounds of North-East India. In: Akhtar, M., Swamy, M. (eds) Anticancer plants: Properties and Application. Springer, Singapore. https://doi.org/10.1007/978-981-10-8548-2_4

Download citation

Publish with us

Policies and ethics