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Transcription Factors and Colorectal Cancer: An Overview

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Book cover Role of Transcription Factors in Gastrointestinal Malignancies

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Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer deaths worldwide among various cancer malignancies. The drugs and targeted therapies that target various intracellular signaling pathways have improved the progression free survival of CRC patients, but they suffer with therapeutic resistance. Dysregulation or mutations in several oncogenic transcriptional factors such as c-MYC, nuclear factor κB (NFκB), NF-E2-related factor 2 (Nrf2), signal transducer and activator of transcription-3 (STAT-3) and p53, were reported to be associated with CRC. Understanding the transcription factors involved in various CRC pathogenesis will be useful in designing novel therapeutic strategies specifically targeting the dysregulated transcription factors. This chapter emphasizes the role of major transcription factors and their dysregulation in CRC.

The original version of this chapter was revised. The book was inadvertently published without Abstracts and Keywords, which are now included in all the chapters. An erratum to this chapter can be found at https://doi.org/10.1007/978-981-10-6728-0_39

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Acknowledgment

Uday Sankar Allam gratefully acknowledges the Dept. of Science and Technology (DST), India, for providing financial support through the Early Career Research Award (ECR/2015/000544). Sk. Md. Jasmine acknowledges the University Grants Commission (UGC), India, for the Maulana Azad National Fellowship (MANF). We also acknowledge the support extended by the Damien Foundation India Trust (DFIT), Chennai.

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  1. Department of Biotechnology, Vikrama Simhapuri University, Nellore, Andhra Pradesh, India

    Uday Sankar Allam, Shilpa Kamatham, Maraline Adarsha & Sk. Md. Jasmine

  2. Damien TB Research Centre, Nellore, Andhra Pradesh, India

    P. V. Giri Prasad

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  1. Uday Sankar Allam
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Correspondence to Uday Sankar Allam .

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  1. Department of Hematology and Medical Oncology, Emory University, Atlanta, Georgia, USA

    Ganji Purnachandra Nagaraju

  2. Department of Biotechnology, Krishna University, Machilipatnam, Andhra Pradesh, India

    Pallaval Veera Bramhachari

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Allam, U.S., Kamatham, S., Adarsha, M., Jasmine, S.M., Giri Prasad, P.V. (2017). Transcription Factors and Colorectal Cancer: An Overview. In: Nagaraju, G., Bramhachari, P. (eds) Role of Transcription Factors in Gastrointestinal Malignancies. Springer, Singapore. https://doi.org/10.1007/978-981-10-6728-0_15

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