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Long Non Coding RNA Biology pp 199–222Cite as

Long Noncoding RNAs in Cancer and Therapeutic Potential

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1008))

Abstract

Long noncoding RNAs (lncRNAs) are the major elements of the mammalian transcriptome that is emerging as a central player controlling diverse cellular mechanisms. Most of the well-studied lncRNAs so far are found to be crucial in regulating cellular processes such as cell cycle, growth, and apoptosis that ensure homeostasis. Owing to their location and distribution in the genome, lncRNAs influence the transcription of a wide range of proteins directly or indirectly by transcriptional and posttranscriptional alterations, which opens up the “LncRNA-cancer paradigm” in a context-dependent manner, i.e., either oncogenic or tumor suppressive. Thus, this chapter is a consolidation of lncRNA association in exhibiting or suppressing the typical cancer hallmarks such as continuous proliferation, surpassing apoptosis, genomic instability, drug resistance, invasion, and metastasis studied till date. In addition, special focus has been given on the efficient application of lncRNAs as potential targets for therapeutics that holds a great promise for future cancer therapy.

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Authors and Affiliations

  1. Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, India

    Arun Renganathan

  2. Laboratory of Molecular Oncology, Division of Thoracic Surgery, University Hospital Zürich, Zürich, Switzerland

    Emanuela Felley-Bosco

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  1. Arun Renganathan
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  2. Emanuela Felley-Bosco
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Correspondence to Emanuela Felley-Bosco .

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  1. Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India

    M.R.S. Rao

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Renganathan, A., Felley-Bosco, E. (2017). Long Noncoding RNAs in Cancer and Therapeutic Potential. In: Rao, M. (eds) Long Non Coding RNA Biology. Advances in Experimental Medicine and Biology, vol 1008. Springer, Singapore. https://doi.org/10.1007/978-981-10-5203-3_7

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